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Method for highly efficiently extracting sinomenine hydrochloride from caulis sinomenii

A technology for sinomenine hydrochloride and sinomenine hydrochloride is applied in the field of high-efficiency extraction of sinomenine hydrochloride, which can solve the problems of high consumption and low extraction efficiency of extract components, and achieve the effects of reducing energy consumption and high extraction efficiency.

Active Publication Date: 2016-02-10
HUNAN ZHENGQING PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The technical problem to be solved by the present invention is the problem that the extraction efficiency of the extract components is low due to the excessive consumption of the percolation solvent of the extract of Caulis sinensis hydrochloric acid in the prior art, and then provides a preparation of Qingfengteng hydrochloric acid extract with less solvent consumption and high extraction efficiency. The method of vine extract

Method used

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  • Method for highly efficiently extracting sinomenine hydrochloride from caulis sinomenii
  • Method for highly efficiently extracting sinomenine hydrochloride from caulis sinomenii
  • Method for highly efficiently extracting sinomenine hydrochloride from caulis sinomenii

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Embodiment 1

[0030] The method for efficiently extracting sinomenine hydrochloride from Caulis Sinomenii in this embodiment includes the following steps:

[0031] (1) Take 600g of crude powder of Caulis serrata raw material, add 600ml of 0.3mol / L HCL solution to soak for 2h, respectively put into 4 interconnected percolation cylinders, then add 0.3mol / L HCl to make each The cylinder is exhausted and filled with hydrochloric acid solution, connected to each percolation cylinder, soaked for 12h;

[0032] (2) Using 0.3mol / L HCL solution as the percolation liquid, open the top liquid inlet of the first percolation cylinder, and proceed from the first percolation cylinder in the order of 8-10ml / min per kilogram of medicinal materials. Continuous percolation operation; open the bottom outlet of the first percolation cylinder to collect 300ml of permeate; close the bottom outlet of the first percolation cylinder and open the bottom outlet of the second percolation cylinder, Collect 300ml of percolate...

Embodiment 2

[0037] The method for efficiently extracting sinomenine hydrochloride from Caulis Sinomenii in this embodiment includes the following steps:

[0038] (1) Take 600g of Caulis Caulis crude powder, add 600ml of 0.3mol / L HCL solution to infiltrate for 2h, and put them into two percolation cylinders connected in series, and then add 0.3mol / L HCl to make each cylinder Exhaust and fill with hydrochloric acid solution, connect each percolation tube, soak for 12h;

[0039] (2) Using 0.3mol / L HCL solution as the percolation liquid, open the top liquid inlet of the first percolation cylinder, and proceed from the first percolation cylinder in the order of 8-10ml / min per kilogram of medicinal materials. Continuous percolation operation; while keeping the percolate continuously injected into each percolation cylinder, open the liquid outlet at the bottom of the first percolation cylinder, collect 600ml of percolate, and then close the bottom of the first percolation cylinder End the liquid out...

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Abstract

The invention provides a method for highly efficiently extracting sinomenine hydrochloride from caulis sinomenii. The method comprises the following steps: a caulis sinomenii raw material is added into a 0.1-1mol / L HCL solution, and is infiltrated for 6.5-30h; the mixture is respectively filled into 2-5 percolators connected in parallel, and is subjected to re-percolation extraction. The extraction method provided by the invention has the advantages of high extraction efficiency and low solvent dose. The method can be widely applied in the field of traditional Chinese medicine active component extraction.

Description

Technical field [0001] The invention belongs to the field of traditional Chinese medicine extraction technology, and specifically relates to a method for efficiently extracting sinomenine hydrochloride from Qingfengteng. Background technique [0002] Qingfengteng is a commonly used Chinese herbal medicine. It has a flat nature, bitter and pungent taste, and returns to the liver and spleen channels. It has the effects of dispelling rheumatism, clearing the meridians and promoting urination, and is mainly used in the treatment of rheumatism, arthralgia, joint swelling, and numbness and itching. [0003] The main component of Sinomenium is alkaloids. The components that have been discovered are sinomenine, isosinomenine, sinomenine, brevisinomenine, sinomenine, double sinomenine, and ethyl sinomenine. Alkali, tetrahydroepiberberine, dauricine, dauricine, tetrahydropalmatine, etc. [0004] Sinomenine is an alkaloid monomer extracted from Sinomenium sinobilis. It is the main active ingr...

Claims

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Application Information

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IPC IPC(8): C07D221/28
Inventor 彭祖仁仇萍滕健吴飞驰
Owner HUNAN ZHENGQING PHARM GRP CO LTD
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