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Medicine composition for inhibiting pancreatic cancer and application of medicine composition

A composition and pancreatic cancer technology, applied in the direction of drug combination, active ingredient of heterocyclic compounds, antineoplastic drugs, etc., to achieve the effect of improving the effect

Inactive Publication Date: 2016-02-24
THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the previous study, the applicant used gene chips to detect the gene expression profiles of pancreatic cancer cells treated with cantharidin and okadaic acid, and found that the regulation of gene expression by cantharidin and okadaic acid was highly consistent, further suggesting that Cantharidin may have unproven cancer-promoting risk in laboratory animals

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  • Medicine composition for inhibiting pancreatic cancer and application of medicine composition
  • Medicine composition for inhibiting pancreatic cancer and application of medicine composition
  • Medicine composition for inhibiting pancreatic cancer and application of medicine composition

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Embodiment Construction

[0024] Animal models of subcutaneous pancreatic cancer xenograft tumor and nude mouse pancreas orthotopic pancreatic cancer xenograft tumor were established. Cantharidin was injected intraperitoneally once every 3 days at a dose of 1 mg / kg. Studies have found that at the level in vivo, cantharidin not only does not inhibit the growth of pancreatic cancer, but promotes the growth of pancreatic cancer ( Figure 1 to Figure 4 ).

[0025] Since cantharidin inhibits the growth of tumor cells in vitro, but promotes the growth of pancreatic cancer in vivo, it is suggested that cantharidin may affect the tumor microenvironment and promote tumor growth by regulating the tumor microenvironment. Through protein chips, we found that cantharidin can promote the expression of various pro-angiogenic genes ( Figure 5 ), suggesting that cantharidin may have the effect of promoting angiogenesis, providing a richer blood supply for tumors, enabling tumor cells to obtain more abundant nutrient...

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Abstract

The invention discloses a medicine composition for inhibiting pancreatic cancer. The medicine composition comprises cantharidin and cantharidin derivatives, as well as a medicine withan anti-angiogenic effect, wherein antharidin and the cantharidin derivatives are selected from one or more of cantharidin, norcantharidin and disodium cantharidinate; the medicine with the anti-angiogenic effect is selected from one or more of bevacizumab, endostar and apatinib. Experiments prove that cantharidin and bevacizumab have a synergistic effect to improve the pancreatic cancer treatment effect of the medicine composition; under the premise that the anti-angiogenic medicine is used for treatment, the anti-tumor effect of cantharidin is obvious. A formula comprising bevacizumab and cantharidin has a clinical application prospect.

Description

technical field [0001] The invention belongs to the field of drugs for treating pancreatic cancer, in particular to a pharmaceutical composition for inhibiting pancreatic cancer and its application. Background technique [0002] Modern medicine has confirmed that the molecular targets of cantharidin (Cantharidin, CAN), the active ingredient of the traditional Chinese medicine Mylabris, are protein phosphatase PP2A and protein phosphatase PP1. PP2A and PP1 can inhibit multiple kinases with tumor-promoting effects in cell signaling pathways, such as Akt, JNK, ERK, PKC, IKK, etc., so PP2A and PP1 are considered as tumor suppressor factors. Cantharidin can inhibit PP2A and PP1, and activate kinases with tumor-promoting effects, so theoretically, cantharidin should have cancer-promoting effects. However, cantharidin has actually been found to have antitumor effects. The applicant found in previous studies that cantharidin can inhibit the growth and metastasis of pancreatic ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/34A61K39/395A61K38/17A61K31/444A61P35/00
CPCA61K31/34A61K31/444A61K38/1709A61K39/395A61K2300/00
Inventor 李伟
Owner THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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