The present invention refers to a novel crystalline polymorphic form of
cabozantinib hemifumarate sesquihydrate designated as Form A, a novel crystalline polymorphic form of
cabozantinib hemifumarate hemipentahydrate designated as Form B and a process for their preparation, a pharmaceutical composition comprising Form A or Form B, and their use for the the treatment of patients with progressive, metastatic medullary
thyroid cancer (MTC) and for the treatment of patients with advanced
renal cell carcinoma (RCC) who have received prior
antiangiogenic therapy treatment of
cancer.