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Yuquan capsules and preparation method thereof

A technology for thirst, polydipsia and digestion, which is applied in the directions of capsule delivery, pharmaceutical formulations, and medical preparations containing active ingredients, and can solve problems such as unsatisfactory curative effect, low curative effect, and delayed disintegration.

Inactive Publication Date: 2016-02-24
HEILONGJIANG JIANGHENG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The curative effect of commercially available Yuquan Capsules is not ideal due to the composition and process. The preparation is prepared by traditional technology, which has the disadvantages of slow disintegration and low curative effect.

Method used

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  • Yuquan capsules and preparation method thereof
  • Yuquan capsules and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Take 144g Styrax, 288g Gansong, 22g Digupi, 200g Tianhuafen, 133g Ophiopogon japonicus, 120g Ginseng, 144g Poria cocos, 144g Black plum, 133g Astragalus membranaceus, 144g licorice, grind them into a 60-mesh coarse powder, and use carbon dioxide supercritical extraction method to extract, The extraction pressure is 16Mpa, the extraction temperature is 21°C, the separator pressure is 13Mpa, the separator temperature is 41°C, the separation time is 2.6 hours, the carbon dioxide flow rate is 25L per hour, and the extract is obtained; the extract is dried under reduced pressure at 60°C to obtain a dry paste; Add 150g of mannitol to the paste, and use a high-energy nano-impact mill to pulverize it into a mixed dry paste powder with a particle size of 200-300nm; take the mixed dry paste powder, 45g of L-malic acid, 45g of cross-linked polyvinylpyrrolidone, and 35g of ethyl cellulose, and mix Uniform, wet granulated with 50% ethanol, dried at 60°C, added 7g of sodium carboxymet...

specific Embodiment 2

[0030] Take 144g Styrax, 288g Gansong, 22g Digupi, 200g Tianhuafen, 133g Ophiopogon japonicus, 120g Ginseng, 144g Poria cocos, 144g Black plum, 133g Astragalus membranaceus, 144g licorice, grind them into a 60-mesh coarse powder, and use carbon dioxide supercritical extraction method to extract, The extraction pressure is 37Mpa, the extraction temperature is 43°C, the separator pressure is 19Mpa, the separator temperature is 53°C, the separation time is 3.5 hours, the carbon dioxide flow rate is 40L per hour, and the extract is obtained; the extract is dried under reduced pressure at 80°C to obtain a dry paste; Add 200g of mannitol to the paste, and use a high-energy nano-impact mill to pulverize it into a mixed dry paste powder with a particle size of 200-300nm; take the mixed dry paste powder, 55g of L-malic acid, 55g of cross-linked polyvinylpyrrolidone, and 45g of ethyl cellulose, and mix Evenly, wet granulate with 70% ethanol, dry at 80°C, add 9g sodium carboxymethyl starc...

Embodiment 3

[0032] Take 144g Styrax, 288g Gansong, 22g Digupi, 200g Tianhuafen, 133g Ophiopogon japonicus, 120g Ginseng, 144g Poria cocos, 144g Black plum, 133g Astragalus membranaceus, 144g licorice, grind them into a 60-mesh coarse powder, and use carbon dioxide supercritical extraction method to extract, The extraction pressure is 27Mpa, the extraction temperature is 32°C, the separator pressure is 16Mpa, the separator temperature is 47°C, the separation time is 3.1 hours, the carbon dioxide flow rate is 33L per hour, and the extract is obtained; the extract is dried under reduced pressure at 70°C to obtain a dry paste; Add 175g of mannitol to the paste, and use a high-energy nano-impact mill to pulverize it into a mixed dry paste powder with a particle size of 200-300nm; take the mixed dry paste powder, 50g of L-malic acid, 50g of cross-linked polyvinylpyrrolidone, and 40g of ethyl cellulose, and mix Evenly, wet granulate with 60% ethanol, dry at 70°C, add 8g of sodium carboxymethyl st...

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Abstract

The invention discloses Yuquan capsules and a preparation method thereof. The Yuquan capsules are characterized in that 144 g of styrax, 288 g of nardostachys jatamansi DC., 22 g of cortex Lycii, 200 g of Chinese trichosanthes roots, 133 g of radix ophiopogonis, 120 g of ginseng, 144 g of poria cocos, 144 g of dark plum fruits, 133 g of milkvetch roots and 144 g of liquorice are taken, extracted through a carbon dioxide supercritical extraction method, subjected to pressure-reducing drying and smashed into nanometer dry paste through a high-energy nanometer impacting grinder, functional auxiliary materials are added, and then the Yuquan capsules are prepared. The disintegration time is obviously shortened, the treatment effect is obviously better than that of Yuquan capsules sold in the market, and a positive effect is achieved.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a Yuquan capsule and a preparation method thereof. Background technique [0002] Yuquan Capsule nourishes yin and replenishes qi, produces body fluid and quenches thirst, clears away heat and annoyance. Indications for deficiency of qi and yin, thirst and excessive drinking, digestion and hunger; diabetes belongs to the above syndromes. The curative effect of commercially available Yuquan Capsules is not satisfactory due to the composition and process, and the preparation is prepared by traditional technology, which has the disadvantages of slow disintegration and low curative effect. Contents of the invention [0003] In order to overcome the above disadvantages, the present invention provides a Yuquan capsule with fast disintegration speed and high curative effect and a preparation method thereof. [0004] Invention embodiment is as follows: [0005] Take 144g ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61K9/48A61P43/00A61P3/10
CPCA61K36/185A61K9/1617A61K9/1652A61K36/076A61K36/258A61K36/428A61K36/481A61K36/484A61K36/736A61K36/815A61K36/8968A61K2236/37A61K2236/51
Inventor 不公告发明人
Owner HEILONGJIANG JIANGHENG PHARMA TECH CO LTD
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