Preparation method and use of penicillin G sodium salt surface molecular imprinting polymer

A surface molecular imprinting and molecular imprinting technology, applied in chemical instruments and methods, and other chemical processes, can solve the problems of molecular recognition site damage, difficulty in eluting template molecules, irregular polymer particles, etc., and achieve strong specificity , strong maneuverability, combined with fast effects

Inactive Publication Date: 2016-03-09
INST OF QUALITY STANDARD & DETECTION TECH YUNNAN ACAD OF AGRI SCI
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Problems solved by technology

[0005] The traditional method of preparing molecularly imprinted materials is the embedding method, which embeds the template molecules too deeply or too tightly, making it difficult to elute the template molecules, and most of the imprinted sites are embedded in the polymer, making the...

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  • Preparation method and use of penicillin G sodium salt surface molecular imprinting polymer
  • Preparation method and use of penicillin G sodium salt surface molecular imprinting polymer
  • Preparation method and use of penicillin G sodium salt surface molecular imprinting polymer

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specific Embodiment

[0084] In this embodiment, α-methacrylic acid (MAA) is used as a functional monomer, ethylene glycol dimethacrylate (EGDMA) is used as a crosslinking agent, azobisisobutyronitrile (AIBN) is used as an initiator, and β-lactam The antibiotic-like penicillin G sodium was used as a template to prepare a molecularly imprinted polymer (MIP) penicillin G sodium molecularly imprinted polymer to detect the residual amount of penicillin G sodium in milk.

[0085] from figure 1 It can be seen that with the increase of adsorption time, the adsorption amount of penicillin sodium by the imprinted polymer increases continuously, and the adsorption equilibrium is basically reached at 20 h, the saturated adsorption amount is 6.48 μg / mg, and the imprinting factor α is 2.03. Compared with MIP, the adsorption of NIP to penicillin G sodium is relatively weak. Among them, the preparation of non-penicillin G sodium surface molecularly imprinted polymer (NIP): The preparation method of non-molecular...

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Abstract

The invention discloses a preparation method of a penicillin G sodium salt surface molecular imprinting polymer. The preparation method comprises dissolving penicillin G sodium salt in a solvent which is a mixture of dimethyl sulfoxide and methanol according to a volume ratio of 4: 1, adding a functional monomer into the solution, carrying out stirring, adding a cross-linking agent and an initiator into the mixed solution, carrying out nitrogen deoxygenation, carrying out a heating reaction process, carrying out washing to remove penicillin G sodium salt as a template molecule after the reaction and carrying out drying to obtain the penicillin G sodium salt surface molecular imprinting polymer. The preparation method has simple processes, good operationality and a low preparation cost. The penicillin G sodium salt surface molecular imprinting polymer has a fast penicillin sodium salt molecule bonding rate, good specificity, high bonding capacity and short adsorption balance time. The penicillin G sodium salt surface molecular imprinting polymer has high desired sample selectivity, good specificity and recovery and recycle of a template molecule and can be used for detecting a certain concentration of penicillin G sodium salt residues in milk.

Description

technical field [0001] The invention belongs to the technical field of molecularly imprinted materials, and in particular relates to a preparation method and application of a penicillin G sodium surface molecularly imprinted polymer. Background technique [0002] Penicillin G sodium is the earliest β-lactam antibiotic, which has a strong antibacterial effect on Gram-positive bacteria and some Gram-negative bacteria. Penicillin can destroy the cell wall of bacteria and play a bactericidal role in the reproduction period of bacterial cells. It has good dispersion in the body, low toxicity, and high efficiency in treating infections, and it plays an important role in clinical treatment. With the widespread application of penicillin antibiotics in animal husbandry, the residues of penicillin and other antibiotics in food have caused certain harm to the human body. For example, eating milk with too much residual penicillin will cause some people to be allergic, and it will cause...

Claims

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Application Information

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IPC IPC(8): C08F222/14C08F220/06C08J9/26B01J20/26B01J20/30
CPCC08F222/14B01J20/268B01J20/3028C08J9/26C08J2335/02C08F220/06
Inventor 刘宏程沈报春杨倩
Owner INST OF QUALITY STANDARD & DETECTION TECH YUNNAN ACAD OF AGRI SCI
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