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Method for preparing organic bromides using microchannel reactor

A technology of microchannel reactor and bromide, applied in organic chemical methods, organic halogenation, organic chemistry, etc., can solve the problems of uncontinuous production cost, high reaction risk, difficult process control, etc., and achieve safe and stable reaction process, The effect of improving reaction efficiency and reducing temperature and pressure runaway phenomenon

Active Publication Date: 2017-09-05
LIANHE CHEM TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The technical problem to be solved by the present invention is to overcome the defects of long reaction time, high reaction risk, difficult process control, non-continuous production and high cost of the preparation method of organic bromides in the prior art, and provides a method using microchannel Reactor prepares the method for organic bromide

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  • Method for preparing organic bromides using microchannel reactor
  • Method for preparing organic bromides using microchannel reactor
  • Method for preparing organic bromides using microchannel reactor

Examples

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Embodiment 1

[0037]

[0038] 1. Raw material preparation: prepare 150mL of dichloromethane solution of cyanobiphenyl and bromine, put it into a container, stir to make it evenly mixed and sealed, wherein the mass concentration of cyanobiphenyl is 10.24%, the mass concentration of bromine is 8.90%, and the mass concentration of cyanobiphenyl is 8.90%. The molar ratio of diphenyl and bromine is 1:1.05. Then weigh 100mL of water into another container and seal it.

[0039] 2, utilize the device of the present invention figure 2 , according to the following steps: (1) the dichloromethane solution that contains cyanobiphenyl and bromine in raw material tank 1 enters Corning microchannel reactor 7 by metering pump 3, and the water in raw material tank 2 enters by metering pump 4 Corning microchannel reactor 7; (2) set each metering pump 3 and metering pump 4 to control the dichloromethane solution flow rate of cyanobiphenyl and bromine: 9.7mL / min, control the water flow rate: 3mL / min, set ...

Embodiment 2

[0042]

[0043] 1. Raw material preparation: Prepare 150 mL of dichloromethane solution of cyanobiphenyl and bromine, put it in a container, stir to make it evenly mixed and sealed, wherein the mass concentration of cyanobiphenyl is 10.24%, the mass concentration of bromine is 8.90%, and the mass concentration of cyanobiphenyl is 8.90%. The molar ratio of diphenyl and bromine is 1:1.05. Then weigh 100mL of water into another container and seal it.

[0044] 2, utilize the device of the present invention figure 2 , according to the following steps: (1) the dichloromethane solution containing cyanobiphenyl and bromine enters the Corning microchannel reactor 7 through the metering pump 3 in the raw material tank 1, and the water in the raw material tank 2 enters the Corning microchannel reactor through the metering pump 4. Microchannel reactor 7; (2) set the flow rate of each metering pump 3 and metering pump 4 to control the dichloromethane solution of cyanobiphenyl and brom...

Embodiment 3

[0047]

[0048] 1. Raw material preparation: Prepare 150 mL of dichloromethane solution of cyanobiphenyl and bromine, put it in a container, stir to make it evenly mixed and sealed, wherein the mass concentration of cyanobiphenyl is 10.28%, the mass concentration of bromine is 8.51%, and the mass concentration of cyanobiphenyl is 10.28%. The molar ratio of diphenyl and bromine is 1:1. Then weigh a certain amount of 100mL water into another container and seal it.

[0049] 2, utilize the device of the present invention figure 2 , according to the following steps: (1) the dichloromethane solution containing cyanobiphenyl and bromine enters the Corning microchannel reactor 7 through the metering pump 3 in the raw material tank 1, and the water in the raw material tank 2 enters the Corning microchannel reactor through the metering pump 4. Microchannel reactor 7; (2) set the flow rate of each metering pump 3 and metering pump 4 to control cyanobiphenyl dichloride and methyl bro...

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Abstract

The invention discloses a method for preparing organic bromides using a microchannel reactor. The method comprises the following steps: carrying out a bromination reaction in a microchannel reactor with a homogeneous solution formed by a compound shown in formula I and a solvent, and a homogeneous solution formed by a bromination reagent and a solvent, to obtain the compound shown in formula II The indicated organic bromide can be, and the time of the bromination reaction is 1 minute to 10 minutes; the temperature of the bromination reaction is -20°C to 60°C. The preparation method of the present invention has extremely short reaction time, precise control of reaction conditions, high safety, is suitable for rapid preparation of products, can be continuously produced, and has low cost, and uses a microchannel reactor to prepare organic bromides, and the selectivity of reaction raw materials is high. , The target compound has good purity and is more suitable for large-scale industrial production.

Description

technical field [0001] The invention relates to a method for preparing organic bromides using a microchannel reactor. Background technique [0002] Organic bromide is an important chemical raw material and an intermediate in the synthesis of other pharmaceutical and pesticides, mainly used in fine chemicals, pharmaceuticals, pesticides, synthetic fibers, printing and dyeing, and organic synthesis. [0003] At present, the bromination method for the large-scale preparation of organic bromides in industry has potential safety hazards, such as severe exothermic reaction, easy flushing, and even the risk of explosion. In the process of industrial production of organic bromides, since the reaction system releases a large amount of heat during the reaction, in the reagent operation, it is necessary to slowly add the material dropwise and keep stirring vigorously to control the reaction. Exothermic is too fast and too violent , to prevent the reactor temperature from being too hig...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07B39/00C07C255/50C07C253/30C07D213/73C07C69/63C07C67/287
Inventor 王萍潘强彪邹本立荆琪袁东升
Owner LIANHE CHEM TECH
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