Unlock instant, AI-driven research and patent intelligence for your innovation.

Novel green and environment-friendly process applied to sevoflurane production

A green and environmentally friendly sevoflurane technology, applied in the field of medicine, can solve difficult and intractable problems

Pending Publication Date: 2022-01-18
FUJIAN BOTE CHEM PROD
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the above publicly reported methods use complex reagents, and are prone to produce three wastes that are difficult to handle, resulting in the inability to be applied in industry

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Novel green and environment-friendly process applied to sevoflurane production
  • Novel green and environment-friendly process applied to sevoflurane production
  • Novel green and environment-friendly process applied to sevoflurane production

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The present invention generates sevoflurane by substitution reaction of hexafluoroisopropyl methyl ether and fluorine gas, wherein the reaction of hexafluoroisopropyl methyl ether and fluorine gas is carried out in a microchannel reactor. Hexafluoroisopropyl methyl ether and fluorine gas are pumped into the two inlets of the microreactor unit synchronously through the metering pump respectively; then pass through a layer of nickel base material and then enter the microchannel mixer to mix and react, and finally pass through the nickel base material. The material and the outlet of the micro-reactor unit enter the collection tank, and the sevoflurane product produced by the reactor has stable quality, green production process and easy control of the reaction process.

[0028] For the above-mentioned microchannel reaction device for preparing sevoflurane, see figure 1 shown.

[0029] A green and environment-friendly production process for sevoflurane, comprising the follo...

Embodiment 2

[0035] A green and environmentally friendly sevoflurane production process, comprising the following steps:

[0036] S1 Hexafluoroisopropyl methyl ether and fluorine gas are simultaneously pumped into the two inlets of the microreactor unit through metering pumps, the flow rate of hexafluoroisopropyl methyl ether is 0.5mL / min, and the flow rate of fluorine gas is 6mL / s ;

[0037] S2 Hexafluoroisopropyl methyl ether and fluorine gas pass through a layer of nickel substrate and then enter the microchannel mixer to mix and react. The temperature of the reactor is controlled at -5°C, and the reaction time is 25s. The outlet of the microreactor unit enters the collection tank;

[0038] S3 washes the product in the collection tank with 2wt% sodium bicarbonate aqueous solution to neutrality, and carries out rectification after drying, and collects fractions with a boiling point of 58 to 59° C. to obtain sevoflurane. The yield of sevoflurane is 89%, and the purity 99.1%.

[0039] T...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a novel green and environment-friendly process applied to sevoflurane production, which is characterized in that hexafluoroisopropyl methyl ether and fluorine gas are subjected to substitution reaction to generate sevoflurane, and the reaction is carried out in a micro-channel reactor. The process comprises the steps: synchronously pumping hexafluoroisopropyl methyl ether and fluorine gas into two inlets of the microreactor unit through a metering pump respectively; enabling the mixture to pass through a layer of nickel base material and then enter a micro-channel mixer for mixing and reaction; and finally, entering a collecting tank through the nickel base material and an outlet of the microreactor unit. The sevoflurane product produced by the reactor is stable in quality, the production process is green and environment-friendly, the reaction process is easy to control, and the reactor is suitable for industrial production.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a new green and environmental protection process applied to the production of sevoflurane. Background technique [0002] Inhalation anesthetics are a class of chemically inactive gases or small molecular weight, low boiling liquids. After mixing with air or oxygen, it enters the lungs through breathing, diffuses into the blood, and distributes to nerve tissue to exert general anesthesia. Fluorinated ether compounds have effective inhalation anesthetic properties, the main varieties of which include desflurane (CF 3 CHFOCHF 2 ), enflurane (ClFCHCF 2 OCHF 2 ) and sevoflurane [(CF 3 ) 2 CHOCH 2 F] etc. Among them, sevoflurane has a rapid loss of consciousness and rapid recovery, which are ideal properties of contemporary inhalation anesthetics, so it is a particularly preferred inhalation anesthetic. Sevoflurane is a colorless, transparent, fragrant, non-irritating volatil...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07C41/22C07C43/12
CPCC07C41/22C07C43/123
Inventor 朱吉洪
Owner FUJIAN BOTE CHEM PROD
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com