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A kind of cross-linked hydrogel based on polyamino acid molecules and its preparation method

A technology for cross-linking hydrogels and polyamino acids, applied in the field of polyamino acids, can solve the problems of obstacles, weak mechanical strength, insufficient toughness, etc., and achieve the effects of wide sources, improved biocompatibility, and simple and easy synthesis methods.

Active Publication Date: 2018-02-13
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the traditional synthetic hydrogels have weak mechanical strength and insufficient toughness. These defects hinder their further application. At present, they are mainly used in fields that do not require high mechanical strength, such as drug controlled release and water-absorbing materials.

Method used

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  • A kind of cross-linked hydrogel based on polyamino acid molecules and its preparation method
  • A kind of cross-linked hydrogel based on polyamino acid molecules and its preparation method
  • A kind of cross-linked hydrogel based on polyamino acid molecules and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] (1) Add 10.00g of γ-benzyl-L-glutamate and triphosgene to 200mL of tetrahydrofuran. The molar ratio of γ-benzyl-L-glutamate to triphosgene is 1:0.33 , Stir and heat at 55°C for 4 hours. After the completion of the reaction, the crude product was purified by recrystallization to obtain white crystals (N-carboxy-intracyclic anhydride compound) (NCA).

[0048] (2) Dissolve 7.00g of white crystals (N-carboxy-intracyclic anhydride compound) and n-hexylamine in dimethylformamide, and the ratio of the initiator to the N-carboxy-intracyclic acid anhydride compound is 1 : 50, 30℃, under inert gas protection, react for 36 hours. After the completion of the reaction, the solution was distilled under reduced pressure to remove the solvent, and then the concentrated solution was precipitated in ether and dried under vacuum to obtain a white solid-poly(γ-benzyl-L-glutamic acid benzyl ester) (PBLG).

[0049] (3) Dissolve 4.00g white solid-poly(γ-benzyl-L-glutamic acid benzyl ester) in 3-...

Embodiment 2

[0053] (1) Add 10.00g of γ-benzyl-L-glutamate and triphosgene to 200mL of tetrahydrofuran, and the molar ratio of γ-benzyl-L-glutamate to triphosgene is 1:0.40 , Stir and heat at 45°C for 5 hours. After the reaction, the solvent was removed with a rotary evaporator, and the crude product was purified by recrystallization to obtain white crystals (N-carboxyl-cyclic anhydride compound) (NCA).

[0054] (2) Dissolve 7.00g of white crystals (N-carboxy-intracyclic anhydride compound) and n-hexylamine in dimethylformamide, and the ratio of the initiator to the N-carboxy-intracyclic acid anhydride compound is 1 : 100, 50 ℃ under inert gas protection conditions, reaction for 24 hours. After the reaction, the solution was distilled under reduced pressure to remove the solvent, and then the concentrated solution was precipitated in the poor solvent ether, and the white solid was obtained by centrifugation. The final product was white solid-poly(γ-benzyl-L). -Benzyl glutamate) (PBLG).

[00...

Embodiment 3

[0059] (1) Add 10.00g of γ-benzyl-L-glutamate and triphosgene to 200mL of tetrahydrofuran. The molar ratio of γ-benzyl-L-glutamate to triphosgene is 1:0.48 , Stir and heat at 35°C for 6 hours. After the reaction, the solvent was removed with a rotary evaporator, and the crude product was purified by recrystallization to obtain white crystals (N-carboxyl-cyclic anhydride compound) (NCA).

[0060] (2) Dissolve 7.00g of white crystals (N-carboxy-intracyclic anhydride compound) and n-hexylamine in dimethylformamide, and the ratio of the initiator to the N-carboxy-intracyclic acid anhydride compound is 1 : 200, 50℃, under inert gas protection, react for 36 hours. After the reaction, the solution was distilled under reduced pressure to remove the solvent, and then the concentrated solution was precipitated in the poor solvent ether, and the white solid was obtained by centrifugation. The final product was white solid-poly(γ-benzyl-L). -Benzyl glutamate) (PBLG).

[0061] (3) Dissolve 4...

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Abstract

The invention relates to the technical field of polyamino acid, in particular to a crosslinking hydrogel based on polyamino acid molecules and a preparation method thereof. A crosslinking agent of the hydrogel is polyamino acid. The method for preparing the hydrogel specially comprises the steps of adopting gamma-benzyl-L-benzyl l-glutamate and triphosgene for undergoing a reaction, obtaining N-carboxyanhydride compound, and undergoing ring-opening polymerization to obtain poly(gamma-benzyl-L-benzyl l-glutamate); making poly(gamma-benzyl-L-benzyl l-glutamate) undergo an ammonolysis reaction with 3-amino-propanol and obtaining poly(N5-(3-hydroxypropyl)L-glutamine; making poly(N5-(3-hydroxypropyl)L-glutamine react with acryloyl chloride, obtaining the polyamino acid non-ionic macromolecular crosslinking agent, and preparing the hydrogel through the crosslinking agent. The mechanical strength of the prepared hydrogel is enhanced, toughness is greatly improved, and the water absorption speed is greatly increased.

Description

Technical field [0001] The invention relates to the technical field of polyamino acids, in particular to a crosslinked hydrogel based on polyamino acid molecules and a preparation method thereof. Background technique [0002] The intersection of materials science and life science has promoted the rapid development of biomaterials. Hydrogel is a gel with water as a dispersion medium. The water-soluble polymer with a network cross-linked structure introduces a part of hydrophobic groups and hydrophilic residues. The hydrophilic residues combine with water molecules to connect the water molecules inside the network, and the hydrophobic residues swell with water. Union polymer. It is a polymer network system, soft in nature, able to maintain a certain shape, can absorb a large amount of water, and has a certain degree of softness and elasticity after absorbing water. It is a unique dispersion composed of a hydrophilic three-dimensional network structure and a large amount of water ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F290/06C08F220/06C08G69/48C08G69/14
Inventor 陈重一兰军王茹
Owner NINGBO UNIV