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Fenbendazole dry suspension and preparation method thereof

A technology of dry fenbendazole and fenbendazole, which is applied in the field of medicine, can solve the problems of low quality stability between batches and inconvenient use, and achieve the effects of good application prospects, convenient portability, and simple preparation process

Inactive Publication Date: 2016-04-06
CHENGDU QIANKUN VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The object of the present invention is to provide a kind of fenbendazole dry suspension and preparation method thereof, to solve the problems of inconvenient use and low quality stability between batches of existing similar products

Method used

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  • Fenbendazole dry suspension and preparation method thereof
  • Fenbendazole dry suspension and preparation method thereof
  • Fenbendazole dry suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The preparation of embodiment 1 pharmaceutical composition of the present invention

[0019] Prescription: Bendazole 50g, Poloxamer 18825g, Sodium Lauryl Sulfate 0.15g, Sorbitol 20g and PEG-600025g.

[0020] Preparation method: add sorbitol, poloxamer 188, PEG-6000, and sodium lauryl sulfate into water, heat to dissolve and boil, then add fenbendazole while it is hot, and stir in a tank mixer until it becomes granular , taken out, dried, and pulverized until completely passing through a No. 9 sieve (75 μm), to obtain fenbendazole dry suspension.

Embodiment 2

[0021] The preparation of embodiment 2 pharmaceutical composition of the present invention

[0022] Prescription: fenbendazole 70g, poloxamer 18825g, sodium lauryl sulfate 0.15g, sorbitol 20g and PEG-600025g.

[0023] Preparation method: add sorbitol, poloxamer 188, PEG-6000, and sodium lauryl sulfate into water, heat to dissolve and boil, then add fenbendazole while it is hot, and stir in a tank mixer until it becomes granular , taken out, dried, and pulverized until completely passing through a No. 9 sieve (75 μm), to obtain fenbendazole dry suspension.

Embodiment 3

[0024] The preparation of embodiment 3 pharmaceutical composition of the present invention

[0025] Prescription: fenbendazole 70g, poloxamer 18825g, sodium lauryl sulfate 0.15g, sorbitol 20g and PEG-600025g.

[0026] Preparation method: add sorbitol, poloxamer 188, PEG-6000, and sodium lauryl sulfate into water, heat to dissolve and boil, then add fenbendazole while it is hot, and stir in a tank mixer until it becomes granular , taken out, dried, and pulverized until completely passing through a No. 9 sieve (75 μm), to obtain fenbendazole dry suspension.

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PUM

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Abstract

The invention discloses a fenbendazole dry suspension and a preparation method thereof. The fenbendazole dry suspension is prepared from, by weight, 50-80 parts of fenbendazole, 15-25 parts of emulgator, 10-25 parts of suspending agent, 10-25 parts of colloid protective agent and 0.05-0.25 part of surface active agent. It is indicated through a quality evaluation experiment that the fenbendazole dry suspension is low in settling velocity, good in physical stability, simple in preparation process, high in bath-to-batch quality stability and convenient to use and carry, the quality requirement of suspensions is met, and good application prospects are achieved.

Description

technical field [0001] The invention relates to a fenbendazole dry suspension and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Fenbendazole is a benzimidazole anthelmintic widely used clinically. It not only has a high anthelmintic activity against gastrointestinal nematode adults and larvae, but also has a good effect on Dictyocaulus, Fasciola and tapeworms. It has a strong effect of killing insect eggs, and has been widely used in the prevention and treatment of gastrointestinal parasites in sheep, cattle, horses, pigs, dogs, cats and wild animals such as deer, ostriches, camels and other animals. [0003] Fenbendazole is white or off-white powder, odorless, tasteless, slightly soluble in methanol, insoluble in water, soluble in glacial acetic acid. Because fenbendazole has the physical and chemical properties of being insoluble in water and general organic solvents, its clinically commonly used dosage forms are mainly ta...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/4184A61P33/10
CPCA61K9/145A61K9/0053A61K31/4184
Inventor 杨海涵丁晓刚吴学渊唐华侨余琴
Owner CHENGDU QIANKUN VETERINARY PHARMA
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