Optimal control system and method for three-dimensional bio-printing aquogel supports

Abstract

The invention discloses an optimal control system and method for three-dimensional bio-printing aquogel supports. The system comprises a quantitative visualization device for the three-dimensional bio-printing aquogel supports based on optical coherence tomography scanning and three-dimensional bio-printing equipment; the visualization device comprises a light source, a low-coherence interference module, a sample scanning module, an interference signal detecting module and a computer. According to the method, the quantitative structure characteristics of the three-dimensional bio-printing aquogel supports are obtained through the OCT technology, the designing and the printing of the supports are fed back on the basis of the results of the quantitative structure characteristics, and the stability and the controllability of three-dimensional manufacturing of the supports are improved by lowering the difference between the designing and the printing through iteration. According to the invention, the requirements of optimal control of three-dimensional bio-printing aquogel for high resolution and wide-range and three-dimensional fast scanning can be met, non-destructive and non-intrusive fast imaging of the whole supports can be realized through the OCT technology, and the information of the whole supports and local shape features of space is quantitatively analyzed based on the algorithm automatically selecting object regions.

Description

Technical field [0001] The invention belongs to the technical field of biomedical engineering, and relates to an optimized control system and method for a three-dimensional printing hydrogel support. Background technique [0002] As an important part of tissue engineering, scaffolds provide necessary space and environment for cell growth. Its chemical composition and physical structure can affect cell activities, such as cell adhesion, migration, proliferation and differentiation. Hydrogels have good biocompatibility, degradability, hydrophilicity and powerful ability to encapsulate cells, which makes hydrogels widely used in the construction of tissue engineering scaffolds. On the other hand, in some special applications, such as the manufacturing of functional tissues and organs, very strict restrictions are imposed on the porous morphology of the stent. The internal structure of the stent needs to be specially tailored to obtain the desired geometric, mechanical, and liquid tr...

AI Technical Summary

Problems solved by technology

[0011] One purpose of the present invention is to address the deficiencies of the prior art, to overcome the defects of insufficient structural precision control of the existing 3D bioprinted hydrogel scaffolds, and propose an optimal control system for a 3D bioprinted hydrogel scaffold based on OCT technology

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