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Application and method for using medium-chain fatty glyceride as condensing agent in dropping capsule

A technology of medium-carbon chain fatty acid glyceride and caprylic capric acid glyceride, which is applied in the application field of medium-carbon chain fatty acid as a condensing agent in the preparation of dropping soft capsules or capsules, and can solve the problem of undiscovered medium-carbon chain fatty acid glyceride Use and other problems to achieve the effect of prolonging the service life, preventing the turbidity of the condensing agent, and reducing the cost

Inactive Publication Date: 2016-05-04
CHINA TOBACCO GUIZHOU IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Up to now, there is no report on the use of medium-carbon chain fatty acid glycerides as a condensing agent in the field of dripping soft capsules or capsules

Method used

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  • Application and method for using medium-chain fatty glyceride as condensing agent in dropping capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 takes fat-soluble vitamins as the method for content dripping capsules

[0029] A method for dripping capsules, the method for dripping comprises the steps of:

[0030] (1) Pour glyceryl caprylate into the condensate storage tank of the capsule preparation machine, adjust its temperature to about 12°C, and set aside;

[0031] (2) Drop the content containing vitamin A, vitamin D, vitamin E, vitamin K and the capsule material into caprylic capric acid glyceride in the form of concentric column flow, and the residence time of the content in the condensing agent is 30s Left and right, molding to obtain prototype capsules;

[0032] (3) Take out the prototype capsule, initially filter out the grease on its surface, then place the capsule in ethyl acetate solvent at room temperature according to the weight ratio of the prototype capsule to ethyl acetate 1:2, and stir to remove the surface of the rough product. grease, repeat the above operation 2 times, and then...

Embodiment 2

[0033] Embodiment 2 takes menthol as the method for content drip capsule

[0034] A method for dripping capsules, the method for dripping comprises the steps of:

[0035] (1) Pour glyceryl caprylate into the condensate storage tank of the capsule preparation machine, adjust its temperature to about 12°C, and set aside;

[0036] (2) the content containing menthol is dropped in caprylic capric acid glyceride, and the residence time of described content in condensing agent is about 30s, and molding obtains prototype dropping pill;

[0037] (3) Take out the rudimentary dropping pills, preliminarily filter out the grease on its surface, then place the dropping pills in an ethanol solvent at room temperature according to the weight ratio of the rudimentary dropping pills to ethanol 1:3, and stir to remove the grease on the surface of the crude product. Grease, then take out described rudiment dropping pill and carry out follow-up operation.

Embodiment 3

[0038] Embodiment 3 drops the method for capsule with the content that contains fragrance material

[0039] A method for dripping capsules, the method for dripping comprises the steps of:

[0040] (1) Pour glyceryl caprylate into the condensate storage tank of the capsule preparation machine, adjust its temperature to about 12°C, and set aside;

[0041] (2) Drop the content containing ethyl lactate and ethyl acetate flavoring material into caprylic capric acid glyceride, and the residence time of the content in the condensing agent is about 30s, and the prototype soft capsule is obtained by molding;

[0042] (3) Take out the prototype soft capsule, preliminarily filter the grease on its surface, then place the capsule in an ethanol solvent at room temperature according to the weight ratio of the prototype capsule to ethanol 1:2, stir to remove the grease on the surface of the crude product, Then take out described rudimentary soft capsule and carry out follow-up operation.

...

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Abstract

The invention relates to the technical field of a condensing agent, and especially relates to applications for using medium-chain fatty glyceride as a condensing agent in dropping soft capsule or capsules. The medium-chain fatty acid is glyceryl caprylate-caprate. The glyceryl caprylate-caprate is short in carbon chains, and has very good compatibility with various kinds of solvents, grease, additives, vitamins, and other substances. The content of unsaturated fattyacid of the medium-chain fatty glyceride is very low, and oxidation stability is good, so service life of a condensing agent can be effectively prolonged. In addition, after the capsules are finished to drop, an organic solvent can be used, for example, ethyl alcohol, to remove grease on the surface of a raw product. The method solves problems in the prior art that grease can be wiped just by conventional gauze and oil-absorbing sheets, and oil removing is not thorough.

Description

technical field [0001] The present invention relates to the technical field of condensing agents, in particular to the application and method of using medium-carbon chain fatty acid glycerides as condensing agents in drop-making capsules, and more specifically to the use of medium-carbon chain fatty acids as condensing agents in the preparation of drop-making soft capsules or capsules applications and how to use them. Background technique [0002] The condensing agent is a necessary condition for the formation of drip capsules. The selection of the condensing agent has the following requirements: safe and harmless; immiscible with the main drug, no chemical reaction; suitable relative density and viscosity; suitable surface tension. During the dripping process, although the glue and the contents do not interact with the condensing agent, the long-term dripping process will also cause the moisture in the glue and the overflowing part of the contents when the capsule is dropp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J3/07C09K5/10C11B9/00
CPCA61J3/07C09K5/10C11B9/00
Inventor 彭黔荣吴艾璟罗光杰徐龙泉韩慧杰刘娜张进叶世著胡世龙
Owner CHINA TOBACCO GUIZHOU IND
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