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Wild buckwheat rhizome preparation and preparation method thereof

A golden buckwheat preparation technology, which is applied to pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problems of patients taking discomfort, poor compliance, and large oral doses of golden buckwheat preparations.

Active Publication Date: 2016-05-11
HUAYI PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the disadvantages of the large amount of oral buckwheat preparations in the background technology, discomfort and poor compliance of patients after taking them, the present invention provides a golden buckwheat preparation and its preparation method. By improving the preparation prescription and preparation process, it is effective in In the case of the same dosage of ingredients, the single dosage of capsules is reduced to 4-5 capsules, which reduces the risk of adverse reactions of patients and improves patient compliance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Preparation method: add 320g of golden buckwheat extract, add 48g of lactose, 20g of hydroxypropyl fiber, mix well, granulate, mix well with 4g of sodium carboxymethyl starch and 8g of silicon dioxide, put 0.4g of each grain into a gelatin hollow Capsules, polished.

[0027] Testing: Comply with the requirements for capsules in Appendix IL of "Pharmacopoeia of the People's Republic of China" (2010 edition), and meet the requirements in the inspection method of capsule disintegration time limit in Appendix XIIA, and can reach the requirements of softening and no hard core within 25 minutes.

Embodiment 2

[0029] Preparation method: add 320g of golden buckwheat extract, add 48g of lactose, 20g of hydroxypropyl fiber, mix well, granulate, mix well with 4g of sodium carboxymethyl starch and 8g of silicon dioxide, put 0.4g of each grain into the plant hollow Capsules, polished.

[0030] Testing: Comply with the requirements for capsules in Appendix IL of "Pharmacopia of the People's Republic of China" (2010 edition), and meet the requirements according to the inspection method of capsule disintegration time limit in Appendix XIIA, and can completely disintegrate and pass through the sieve within 25 minutes.

Embodiment 3

[0032] Preparation method: add 320g of golden buckwheat extract, add 48g of lactose, 20g of hydroxypropyl fiber, mix well, granulate, mix with 4g of sodium carboxymethyl starch and 8g of silicon dioxide, put into enteric coating at 0.4g per grain Empty gelatin capsules, polished.

[0033] Testing: Comply with the requirements for capsules in Appendix IL of "Pharmacopoeia of the People's Republic of China" (2010 edition), and meet the requirements according to the inspection method for the disintegration time limit of enteric-coated capsules in Appendix XIIA, and can reach the requirement of softening without hard core within 25 minutes.

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Abstract

The invention belongs to the field of medicine preparations, and particularly relates to a wild buckwheat rhizome preparation and a preparation method thereof. The wild buckwheat rhizome preparation is in a capsule form, and content in capsules is prepared from raw materials and auxiliary material materials including, by weight, 80% of wild buckwheat rhizome extract, 10-14% of lactose, 4-6% of hydroxypropyl fibers, 0.5-2% of sodium carboxymethyl starch and 1-3% of silicon dioxide. The preparation method of the wild buckwheat rhizome preparation includes the steps that 12% of lactose and 5% of hydroxypropyl fibers are added into 80% of wild buckwheat rhizome extract, lactose, hydroxypropyl fibers and wild buckwheat rhizome extract are mixed evenly and granulated, and the granulated mixture, 1% of sodium carboxymethyl starch and 2% silicon dioxide are evenly mixed and then put into the capsules. According to the wild buckwheat rhizome preparation and the preparation method thereof, the single dose of the capsules is reduced to 4-5 under the condition that the dose of effective ingredients of wild buckwheat rhizome extract is not changed, so that the risk of untoward effects on patients is reduced, and the compliance of patients is improved.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a golden buckwheat preparation and a preparation method thereof. Background technique [0002] Golden buckwheat is a plant of Polygonaceae, also known as tartary buckwheat, buckwheat angelica, buckwheat notoginseng, jinsuoyinkai, etc. It has been proved by experiments that the extract of the drug has inhibitory effect on transplanted tumors in animals and enhances experimental immune indexes. According to pharmacological experiments, the active ingredients of golden buckwheat to suppress tumors are tannins. [0003] Tannin is a kind of polyphenolic compound with complex structure existing in plants, and its physical and chemical properties will change accordingly with the change of its constituent structural units, degree of polymerization and other factors. The properties of tannins extracted from different plants and different extraction methods of the s...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/02A61K47/38A61K47/26A61K36/70
CPCA61K9/4816A61K9/485A61K9/4858A61K9/4866A61K36/70
Inventor 戴玮肖苏萍常新全王继永兰青山王龙虎
Owner HUAYI PHARMA
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