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Use of compound triptolide in choroidal neovascularization

A technology of triptolide and neovascularization, which is applied in the application field of the compound triptolide in choroidal neovascularization, can solve the problems of ineffectiveness, poor prognosis, and poor treatment effect, and achieve the purpose of reducing scar formation, inhibiting formation and progression , improve the effect of treatment and prognosis

Inactive Publication Date: 2016-05-11
金陈进
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Problems solved by technology

[0003] In order to overcome the shortcomings of the existing choroidal neovascularization-related diseases such as poor therapeutic effect, ineffectiveness and poor prognosis, the present invention provides a brand-new treatment, expands the application range of clinical first-line drugs, improves the therapeutic effect and prognosis of choroidal-related diseases, and also Provides patients with a low-cost therapeutic drug with high social benefits

Method used

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Embodiment Construction

[0006] 1: After oral administration, triptolide or its mixture as an added ingredient acts on the whole body and local lesions to exert an inhibitory effect on the related mechanism of choroidal neovascularization, so as to inhibit the formation and progress of choroidal neovascularization and reduce choroidal neovascularization Scarring after atrophy of blood vessels to preserve and / or improve vision.

[0007] Two: Triptolide or its mixture as an added ingredient is injected into the vitreous cavity or into the eye, and acts locally to exert an inhibitory effect on the relevant mechanism of choroidal neovascularization, so as to inhibit the formation and progress of choroidal neovascularization. Reduce the scar formation after choroidal neovascularization atrophy, achieve the effect of preserving and / or improving vision.

[0008] Three: Triptolide or its mixture as an added ingredient is administered through the intravenous route, acting on the whole body and local lesions, e...

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Abstract

The invention discloses a use of a compound triptolide in choroidal neovascularization. After oral administration, intravenous systemic administration and / or eye local administration, a triptolide clinical drug or a triptolide mixture clinical drug with the triptolide additive can act the whole human body and local lesions, inhibit a choroidal neovascularization formation related mechanism thereby inhibiting choroidal neovascularization formation and development, reduce choroidal neovascularization atrophy-caused scar and realize eyesight keeping and / or improvement.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extracted monomer compound triptolide, which has been used in clinical trials, can significantly inhibit the formation of new blood vessels, and has a therapeutic effect on related diseases characterized by choroidal new blood vessels. Background technique [0002] At present, triptolide is the main active ingredient of the traditional Chinese medicine Tripterygium wilfordii, which has anti-inflammation, immune regulation, and inhibition of tumor cell proliferation. It has been widely used in clinical treatment. Diseases characterized by choroidal neovascularization, especially age-related macular degeneration, cause irreversible vision loss to patients. These diseases have a large number of patients, cause great physical and psychological damage to the patients, and often make the quality of life of the patients drop significantly. But so far, there is no treatment that can improve the prognosi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/585A61P27/02A61P29/00
Inventor 金陈进
Owner 金陈进
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