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A dopamine-crosslinked gelatin liquid-absorbing hemostatic sponge and preparation method thereof

A technology of hemostatic sponge and dopamine, which is applied in the direction of absorbent pads, pharmaceutical formulas, bandages, etc., can solve the problems of poor biocompatibility, troublesome surgery, and affecting the surgical field of view, and achieve low requirements for instruments and equipment, realize industrialized production, and facilitate the process The effect of the operation

Active Publication Date: 2018-11-30
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] At present, the liquid-absorbing hemostatic dressings used in clinical surgery usually include medical absorbent cotton or fiber, acetalized polyvinyl alcohol sponge and acetalized gelatin sponge, but the above dressings usually have the following disadvantages: medical absorbent cotton or fiber contains fiber filaments or fiber heads, During the operation, the fiber shedding often affects the surgical field of view and is not conducive to wound healing; the raw material polyvinyl alcohol of the acetalized polyvinyl alcohol sponge is a chemically synthesized raw material, and its biocompatibility is poor, and the acetalized polyvinyl alcohol sponge and acetalized polyvinyl alcohol sponge Aldehyde gelatin sponges usually use aldehyde cross-linking agents such as glutaraldehyde and formaldehyde. Bacterial saline can only be used after treatment, which will bring trouble to the operation and increase the risk of infection

Method used

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  • A dopamine-crosslinked gelatin liquid-absorbing hemostatic sponge and preparation method thereof

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preparation example Construction

[0029] The present invention also includes the preparation method of the gelatin liquid-absorbing hemostatic sponge cross-linked by dopamine, comprising the following steps:

[0030] Dissolving Pluronic, succinic anhydride, 4-dimethylaminopyridine and triethylamine in an organic solvent, stirring and reacting at 20 to 30°C for 25 to 35 hours, and evaporating under reduced pressure to remove the organic solvent to obtain a residue; The organic solvent is 1,4-dioxane, methylene chloride or ethyl acetate; the mass volume ratio of the pluronic, succinic anhydride, 4-dimethylaminopyridine, triethylamine and organic solvent is 90 ~110g:1g:1~1.5g:0.5~0.8g:350~450ml;

[0031] will step Add chloroform to the obtained residue to dissolve, add diethyl ether under slow stirring to form a precipitate, collect the precipitate by filtration, repeat this step for 3 to 5 times to obtain a white solid, and vacuum dry the obtained white solid at 20 to 30°C , obtain carboxylated pluronic; t...

Embodiment 1

[0048] Dissolve 90g of Pluronic P407, 1g of succinic anhydride, 1g of 4-dimethylaminopyridine and 0.5g of triethylamine in 350ml of 1,4-dioxane, stir and react at 20°C for 25 hours, evaporate under reduced pressure to remove 1 ,4-dioxane to give the residue;

[0049] will step The resulting residue was dissolved in 10 ml of chloroform, and 500 ml of ether was added under slow stirring to form a precipitate. The resulting precipitate was collected by filtration, and the process was repeated for 3 times to obtain a white solid. The resulting white solid was vacuum-dried at 20°C to obtain Carboxylated Pluronic P407;

[0050] Step 45g The resulting carboxylated Pluronic P407, 15g of 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride were dissolved in 300ml of MES buffer, stirred for 20 minutes and then added with 15g of N-hydroxysuccinimide , after stirring and reacting for 20 minutes, add 45g of gelatin, stir and react at 40°C for 25 hours to obtain a reaction ...

Embodiment 2

[0055] Dissolve 110g of Pluronic F68, 1g of succinic anhydride, 1.5g of 4-dimethylaminopyridine and 0.8g of triethylamine in 450ml of dichloromethane, stir and react at 30°C for 35 hours, evaporate the dichloromethane under reduced pressure to obtain leftovers;

[0056] will step The resulting residue was dissolved in 15 ml of chloroform, and 1500 ml of ether was added under slow stirring to form a precipitate. The resulting precipitate was collected by filtration, and this step was repeated for 5 times to obtain a white solid, which was vacuum-dried at 30°C to obtain Carboxylated Pluronic F68;

[0057] Step 80g The resulting carboxylated Pluronic F68, 20g of 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride were dissolved in 600ml of MES buffer, stirred for 40 minutes and then added with 20g of N-hydroxysuccinimide , after stirring and reacting for 40 minutes, add 60 g of gelatin, stir and react at 40° C. for 35 hours to obtain a reaction solution;

[005...

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Abstract

The invention discloses a dopamine-crosslinked gelatin liquid-absorbing hemostatic sponge and a preparation method thereof, which comprises the steps of obtaining super-hydrophilic modified gelatin from carboxylated pluronic-grafted gelatin, and then converting the obtained super-hydrophilic modified gelatin into Dopamine hydrochloride is a cross-linking agent, which is oxidized under the action of a strong oxidant, and the spongy gelatin liquid-absorbing hemostatic dressing obtained by adding medical auxiliary materials through mechanical foaming and freeze-drying; the dopamine-crosslinked gelatin liquid-absorbing hemostatic sponge of the present invention is a sponge Shaped medical dressing, the dressing presents a fine and porous sponge shape, the surface is soft when in contact with human tissue, can be used directly without infiltration, has high biocompatibility, can be combined with thrombin, and can be completely biodegraded and can quickly absorb liquid , Immediate hemostasis, adhesion to wounds, suitable for aspiration and hemostasis of various surgical incisions and wounds, especially for aspiration of ophthalmic surgery.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a dopamine-crosslinked gelatin liquid-absorbing hemostatic sponge and a preparation method thereof. Background technique [0002] At present, the liquid-absorbing hemostatic dressings used in clinical surgery usually include medical absorbent cotton or fiber, acetalized polyvinyl alcohol sponge and acetalized gelatin sponge, but the above dressings usually have the following disadvantages: medical absorbent cotton or fiber contains fiber filaments or fiber heads, During the operation, the fiber shedding often affects the surgical field of view, and is also not conducive to wound healing; the raw material polyvinyl alcohol of the acetalized polyvinyl alcohol sponge is a chemically synthesized raw material, and its biocompatibility is poor, and the acetalized polyvinyl alcohol sponge and acetalized polyvinyl alcohol sponge Aldehyde gelatin sponges usually use aldehyde cross...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/32A61L15/42A61L15/44A61L15/20
CPCA61L15/20A61L15/32A61L15/425A61L15/44A61L2300/204A61L2300/216A61L2400/04
Inventor 王晓晨郈秀菊李俊起李红梅张素文朱肖杰朱小敏王传栋夏毅然孟建文
Owner SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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