Metal organic compound and preparation method and use thereof

A technology of organic compounds and metals, applied in organic chemistry, drug combination, antineoplastic drugs, etc.

Inactive Publication Date: 2016-05-11
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The research on metal-organic hybrid materials in anti-tumor is limited to carrying anti-cancer drugs, and it has not been reported directly as a drug to kill cancer cells.

Method used

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  • Metal organic compound and preparation method and use thereof
  • Metal organic compound and preparation method and use thereof
  • Metal organic compound and preparation method and use thereof

Examples

Experimental program
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Effect test

Embodiment

[0025] A specific embodiment of the present invention is that a metal organic compound has the molecular formula [Cd(3-(4'-imidazolylphenyl)-5-(pyridin-2"-yl)-1,2,4-tri azole) 2 2H 2 O], is a metal organic compound composed of cadmium ion and 3-(4'-imidazolylphenyl)-5-(pyridin-2"-yl)-1,2,4-triazole ligand. The metal organic compound , which can be obtained by the following method:

[0026] Synthesized by test tube diffusion method.

[0027] Step 1: Prepare the solution

[0028] Solution A: Weigh 10 mg of cadmium acetate and dissolve in 5 mL of dichloromethane solvent containing 5% methanol.

[0029] Solution B: Make a mixed solution of N,N'dimethylformamide and dichloromethane at a volume ratio of 1:1.

[0030] Solution C: Weigh 6mg ligand 3-(4'-imidazolephenyl)-5-(pyridin-2"-yl)-1,2,4-triazole and dissolve it in 5ml N,N'dimethylformamide , and adjust its pH to 6.5 with dilute ammonia solution.

[0031] Step 2: Layered Join

[0032] Use a fine needle to draw 5ml of solut...

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Abstract

The present invention discloses a metal organic compound and a preparation method and use thereof, belongs to the technical field of organic chemistry, and can effectively solve the technical problems in the aspects of preparation of a metal organic compound and use of the metal organic compound in preparation of a drug for killing liver cancer tumor cells. The metal organic compound is obtained by liquid-liquid layering diffusion method, the Chinese name of the metal organic compound is bis-3-(4 '-imidazol phenyl)-5-(pyridine-2''-yl)-1, 2, 4-triazole cadmium dehydrate, the molecular formula is [Cd (3-(4'-imidazol phenyl)-5-(pyridin-2''-yl)-1,2,4-triazole) 2.2H2O], the preparation method is disclosed, and the cadmium compound is used for preparation of an antitumor drug, or is used as a carrier for carrying the antitumor drug and the antitumor drug used in cancer.

Description

technical field [0001] The invention relates to the technical field of organic chemistry. Background technique [0002] Metal-organic hybrid materials are crystalline or amorphous materials formed by coordination between metal ions and organic small molecule ligands. This type of material has advantages over other materials in terms of pores and specific surface area. Adsorption and separation, catalysts, drug loading, fluorescence, etc. all have great application prospects, and some metal-organic hybrids themselves have anti-tumor or anti-oxidation properties, so they can be used as drugs after reliable pharmacological experiments. For the treatment of diseases. [0003] Metal-organic hybrid materials can be prepared by a variety of methods, the most commonly used are the following: nano-co-precipitation method, solvothermal method, inverse microemulsion method, and diffusion method. The first method usually obtains amorphous hybrid materials, and the latter methods can g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D401/14A61P35/00A61P35/02
CPCC07D401/14
Inventor 代海玉王萃娟唐豫缘邱光美毛凯力黄帅周先礼
Owner SOUTHWEST JIAOTONG UNIV
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