Method for imposing pressure to control selectance of ion transmission in nano-hole
An ion transmission and pressure application technology, applied in the field of microfluidics, can solve the problems of difficult realization, uncontrollable adjustment of ion selectivity and change speed, high requirements, etc. The effect of large ion selectivity
Inactive Publication Date: 2016-05-11
NANJING UNIV OF SCI & TECH
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[0003] So far, people mostly use to adjust the pH value and concentration of the solution, as well as the magnitude of the voltage to obtain a higher ion selectivity, but to obtain a higher ion selectivity, the requirements for these three parameters are relatively high, and it is not easy to achieve , and these three parameters restrict each other, and it is uncontrollable to adjust the size and change speed of ion selectivity
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[0012] Below in conjunction with accompanying drawing and specific embodiment, further illustrate the present invention, should be understood that these embodiments are only for illustrating the present invention and are not intended to limit the scope of the present invention, after having read the present invention, those skilled in the art will understand various aspects of the present invention Modifications in equivalent forms all fall within the scope defined by the appended claims of this application.
[0013] A method for applying pressure to control the selectivity of ion transmission in nanopores of the present invention includes: applying pressure at one end of the nanopore reservoir system while applying voltage, adjusting the size of the pressure to control the size of the selectivity, and adjusting the size of the voltage to control the pressure pair selection speed of change.
[0014] As a preferred solution, use such as figure 1 The implementation shown, that ...
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The invention discloses a method for imposing pressure to control selectance of ion transmission in a nano-hole. The method comprises steps of imposing pressure while imposing voltage on one end of a nano-hole reservoir system; and using huge pressure intensity generated by certain pressure imposed on a small area to effectively restrain and control selectance of ion transmission. According to the invention, by use of the huge pressure intensity, ions in the nano-hole are encouraged to flow rapidly; by screening the flowing ions via voltage, quite high ion selectance can be obtained; compared with control over ion selectance by pure voltage, control over the ion selectance by voltage is free from restrains of the pH value and condensation of solution; and the control is carried out in single direction at an adjustable speed and is quite flexible and controllable.
Description
technical field [0001] The invention relates to the field of microfluidic technology, in particular to a method for applying pressure to control ion transmission selectivity in nanopores. Background technique [0002] Inspired by the fact that biological ion channels in living organisms can selectively permeate specific kinds of ions, it is increasingly hoped to develop synthetic devices based on nanopores to actively control the transport of ions, fluids, and biological particles, and provide a variety of biotransducer Sensing applications detect small biomolecules. The remarkable improvement of nanofabrication technology has also made the research and application of nanopore-based technology possible. Recently, nanopore-based experimental studies have shown that when the thickness of the electric double layer is comparable to the characteristic length of the nanopore, its electrostatic interaction becomes apparent and can significantly affect the ion transport in the nano...
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IPC IPC(8): G05D16/20
CPCG05D16/2093
Inventor 单惠霞曾振平桂林卿季晓旭
Owner NANJING UNIV OF SCI & TECH