Mass spectrometry information-based biological characteristic image identification method

A biometric and image recognition technology, applied in character and pattern recognition, measuring devices, instruments, etc., to achieve the effect of simple and direct process, improved recognition efficiency, high resolution and recognition efficiency

Active Publication Date: 2016-05-11
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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Problems solved by technology

[0003] The technical problem to be solved by the present invention is a mass spectrometry feature image recognition method based on mass spectrometry information. The present invention changes the traditional method and converts the chromatogram-mass spectrometry information of biological samples into m / z-t-I images to reflect the mass difference of each compound. Through Identify spatial information such as contours and textures of images to improve the efficiency of identifying biological samples

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  • Mass spectrometry information-based biological characteristic image identification method

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Embodiment

[0031] Comparative Analysis of Astragalus and Epimedium

[0032] 1) Preparation of Chinese medicine sample solution: Accurately weigh 100 mg of each medicinal material dry powder,

[0033] Add 1ml of methanol with a volume concentration of 50% to each medicinal material powder, ultrasonically extract for 15 minutes, centrifuge for 5 minutes, take the supernatant, repeat the extraction once, and combine the two supernatants to pass through a 0.22um filter membrane.

[0034]2) Ultra-high performance liquid chromatography-mass spectrometry analysis: full-spectrum analysis of samples was performed using an Agilent 1290 ultra-high performance liquid chromatography system (Agilent, Waldbronn, Germany) in series with a 6520Q-TOF-MS (Agilent Corp, USA). The experiment used Agilent's ZORBAX Eclipse Plus C18 chromatographic column (3.0*150mm, 1.8um), mobile phase A was water (0.5% acetic acid), B phase was acetonitrile, gradient elution: 0-15min, B phase 5%-100%, 15 -20min, keep 100% o...

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Abstract

The invention provides a mass spectrometry information-based biological characteristic image identification method. The method comprises the steps as follows: firstly, chromatography-mass spectrometry analysis is carried out on a sample, and m / z, t and I of compounds in the sample are obtained; with m / z and t as coordinates, the mass spectrometry signal intensity of the compounds is represented by chromatic values of points; a generated m / z-t-I image is suitable for identification of the sample; biological characteristics in the sample are converted into spatial characteristics by extracting overall spatial information and local spatial information, for example, outlines, textures or colority from the image; the sample in which the composition or abundance of each compound is different displays specific spatial information; and closely clustered data points are selected, the characteristic region of the image is found out; and similarity analysis is carried out for sample identification and nature judgment. The mass spectrometry information-based biological characteristic image identification method breaks through a method for identifying the sample by mass spectrometry signal intensity or a method for identifying the sample by only mass spectrometry information of a few of index compounds and greatly improves the mass spectrometry-based complicated sample identification ability.

Description

technical field [0001] The invention relates to a complex sample rapid identification method based on visual mass spectrum information technology. Background technique [0002] The identification of complex biological samples is one of the most challenging topics in various research fields today. Complex samples contain multiple chemical components with a wide variety of compounds with widely varying physical and chemical properties. Using the information of these compounds to identify complex samples and classify them has a strong demand in the fields of animal and plant species judgment and disease diagnosis. Mass spectrometry is an effective technique that can be used to identify complex samples. Especially when combined with chromatographic technology, it can separate and detect complex samples, and obtain the mass spectrum information of parent ions and product ions of each compound in the sample, such as mass-to-charge ratio and charge number, etc. Its advantages are...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06K9/00G01N27/62
Inventor 张晓哲赵楠
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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