Adjustable three-axis imaging mechanism based on skin confocal system

Abstract

The invention provides an adjustable triaxial imaging mechanism based on a skin confocal system. The adjustable triaxial imaging mechanism is provided with a laser device, an imaging optical system and an image detector, wherein the imaging optical system is provided with an adjustable triaxial imaging mechanism body, the adjustable triaxial imaging mechanism body comprises a reflecting mirror combined module composed of three reflecting mirrors, an objective lens, a substrate and a power module, and the power module is provided with a first x-axis driving motor, a second y-axis driving motor, a third z-axis coarse driving motor and a fourth z-axis fine driving motor; the first reflecting mirror and the second reflecting mirror are respectively connected to the first motor, and the third reflecting mirror is connected to the second motor. On the premise of ensuring stable imaging of skin tissue, transverse two-dimension imaging and axial tomography imaging in a certain region are achieved through the adjustable triaxial imaging mechanism body, so that large-visual-field high-resolution confocal images and skin images of different tissue forms at different depths are obtained, and effective information is provided for follow-up skin disease diagnosis.

Description

technical field [0001] The invention relates to confocal microscopes in the field of micro-optics. More specifically, the present invention relates to an adjustable three-axis imaging mechanism based on a skin confocal system. Background technique [0002] The confocal microscope has the characteristics of high resolution, especially axial high resolution, which can perform optical tomography on the axial direction of the sample, thereby reconstructing the three-dimensional image of the sample. Confocal microscopy has been applied in dermatological clinical testing for more than ten years. It can obtain living skin images at the cell level at a depth of 200-350 μm. The imaging is closest to histopathology, and it is convenient for the observation of changes at the skin cell level. [0003] At present, there are Vivascope series skin CT products produced by Lucid Company in the United States abroad, but their structure is too complicated in terms of three-axis adjustable ima...

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Problems solved by technology

[0003] At present, there are Vivascope series skin CT products produced by Lucid Company in the United States abroad, but their structure is too complicated in terms of three-axis adjustable imaging of the objective lens. The axial drive of the objective lens uses a cam mechanism, which requires additional gear transmission. It occupies too much space in the axial direction; the lateral movement is also driven by two one-dimensional motors, but the driving object is the nasal tube around the objective lens, so as to indirectly realize the lateral two-axis movement of the objective lens in the nasal tube. In this way, the motor load It is large, and requires synchronous movement of the skin and imaging ring with the nasal tube, which is very inconvenient and less feasible

[0004] In China, there are few researches on skin confocal systems, mainly on Shanghai Jiao Tong University and Peking University, but the implementation of the prototype function is relatively weak, and there is no mechanism for realizing the adjustable three-axis imaging method.

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