A miniaturized secondary vacuum rectangular ion trap mass spectrometer and detection method thereof

Abstract

A miniaturized secondary vacuum rectangular ion trap mass spectrometer and detection method thereof, wherein the mass spectrometer includes a two-stage vacuum chamber: the first stage vacuum chamber includes an atmospheric pressure interface sampling cone, a quadrupole rod and an ion gate electrode, The three form a quadrupole ion trap; the second-stage vacuum chamber includes a rectangular ion trap, an ion detector and a capillary; an ion optical element is arranged between the two-stage vacuum chambers. The detection method includes controlling the quadrupole ion trap in the primary chamber to be in the storage ion trap mode and the synchronous analysis ion trap mode, which can improve the sensitivity of the mass spectrometer, reduce the limit of quantification, improve the analysis throughput, and reduce the influence of space charge effects, Increase resolution. The quadrupole here does not require high resolution and low processing accuracy, and the rectangular well is easy to process and assemble, which is convenient for miniaturization. At the same time, the detection method can ensure good analytical performance, and has great potential in the field of on-site analysis and detection. Wide application prospects.

Description

technical field [0001] The invention relates to the field of in-situ and on-site detection of biochemical substances by using a mass spectrometer, in particular to a small rectangular ion trap mass spectrometer with a secondary vacuum system and a detection method for improving its analysis performance. Background technique [0002] Mass spectrometry is a universal chemical analysis method with high specificity, high sensitivity and wide application. In recent years, the increasing demand for in-situ analysis and on-site detection has led to the rapid development and application of miniaturized mass spectrometers. Among all kinds of mass spectrometers, ion trap mass spectrometers play a huge role in life sciences, medicine and health, environmental monitoring, food safety and other fields due to their relatively simple structure and powerful time-tandem mass spectrometry capabilities. However, the traditional linear ion trap is not convenient for miniaturization due to the ...

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Problems solved by technology

[0005] The purpose of the present invention is to provide a small rectangular ion trap mass spectrometer with a two-stage vacuum system and a detection method for improving its analytical performance, so as to overcome the problem of simple structure but low performance of the small-scale mass spectrometer with a first-stage cavity, and at the same time overcome Although the existing commercial mass spectrometer has high performance, but the system is complicated, the mass spectrometer not only has a simple structure, does not require high processing accuracy, is convenient for miniaturization, but also has good analytical performance

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