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A kind of Acanthopanax polygonatum leaf extract for improving sleep and lowering blood sugar and its preparation method and application

A technology of bamboo leaf extract and Acanthopanax leaf extract, which is applied in the preparation of Acanthopanax Polygonatum leaf extract. The application field of the extract in improving sleep and lowering blood sugar can solve the problems that have not been reported, and achieve remarkable curative effect , low cost, and the effect of improving insomnia symptoms

Active Publication Date: 2019-08-16
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Acanthopanax leaves and Yuzhu leaves have good therapeutic effects on insomnia and hyperglycemia respectively, but there is no report on the combination of the two active ingredients for improving sleep and hyperglycemia

Method used

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  • A kind of Acanthopanax polygonatum leaf extract for improving sleep and lowering blood sugar and its preparation method and application
  • A kind of Acanthopanax polygonatum leaf extract for improving sleep and lowering blood sugar and its preparation method and application
  • A kind of Acanthopanax polygonatum leaf extract for improving sleep and lowering blood sugar and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] With 3.0kg of Acanthopanax leaves and 1.0kg of Polygonatum odoratum leaves, extract 2 times with 6 times the amount of 50% ethanol (mass ratio volume is 1:6) and heat and reflux for 3 hours each time, combine the extracts, reclaim the ethanol, An ethanol extract (extract specific gravity 1.02 to 1.07) was obtained. After the ethanol extract was suspended in water, it was extracted three times with 2 times the amount of petroleum ether (the upper layer was the petroleum ether layer, and the lower layer was the water layer). The water layer is loaded onto the AB-8 macroporous adsorption resin column (column diameter:column height=1:2) for adsorption, and the sample loading flow rate is 1.0 to 1.5 times the column volume per hour. Pore ​​adsorption resin column (5 to 10 times the column volume), discard the water eluate. Use 10% ethanol (4 to 6 times the column volume), 50% ethanol (6 to 8 times the column volume), and 90% ethanol (8 to 10 times the column volume) to elut...

Embodiment 2

[0024] With Acanthopanax 3.0kg and Polygonatum Polygonatum leaves 1.0kg, extract 3 times with 7 times the amount of 60% ethanol (mass ratio volume is 1:7) heating and refluxing, 2 hours each time, combine the extracts, reclaim the ethanol, An ethanol extract (extract specific gravity 1.02 to 1.07) was obtained. The ethanol extract was suspended in water and then extracted three times with 2 times the amount of petroleum ether (the upper layer was the petroleum ether layer and the lower layer was the water layer). The water layer is loaded to the AB-8 type macroporous adsorption resin column chromatography (column diameter:column height=1:3) for adsorption, the sample loading flow rate is 1.0 to 1.5 times the column volume per hour, and the sample is washed with distilled water after sample loading. Pore ​​adsorption resin column (5 to 10 times the column volume), discard the water eluate. Use 10% ethanol (4-6 times the column volume), 50% ethanol (6-8 times the column volume)...

Embodiment 3

[0027]With Acanthopanax 3.0kg and Polygonatum Polygonatum leaves 1.0kg, extract 2 times with 8 times the amount of 50% ethanol (mass ratio volume is 1:8) heating and refluxing, 1 hour each time, combine the extracts, reclaim the ethanol, An ethanol extract (extract specific gravity 1.02 to 1.07) was obtained. After the ethanol extract was suspended in water, it was extracted three times with 2 times the amount of petroleum ether (the upper layer was the petroleum ether layer, and the lower layer was the water layer). The water layer is loaded onto the AB-8 macroporous adsorption resin column (column diameter:column height=1:4) for adsorption, and the sample loading flow rate is 1.0 to 1.5 times the column volume per hour. Pore ​​adsorption resin column (5 to 10 times the column volume), discard the water eluate. Use 10% ethanol (5 to 7 times the column volume), 50% ethanol (6 to 8 times the column volume), and 90% ethanol (7 to 9 times the column volume) to elute, and the flo...

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Abstract

The invention relates to acanthopanax senticosus leaf and polygonatum odoratum leaf extract for improving sleeping and reducing blood sugar and a preparing method and application thereof.The acanthopanax senticosus leaf and polygonatum odoratum leaf extract mainly contains flavone and saponin components, the saponin component accounts for 25% or more, and the flavone component accounts for 15% or more of the acanthopanax senticosus leaf and polygonatum odoratum leaf extract.It is proved through pharmacological experiments that the acanthopanax senticosus leaf and polygonatum odoratum leaf extract has effects of improving sleeping and reducing and controlling blood sugar, the extract can individually serve as an active pharmaceutical ingredient or be mixed with other components to be prepared into various dosage forms to be used, and the acanthopanax senticosus leaf and polygonatum odoratum leaf extract can be mixed with pharmaceutically acceptable uxiliary materials to be prepared into tablets, granules, capsules and other oral delivery dosage forms.A new compound 30-noroleanolic acid-3-O-beta-D-glucopyranoside is found in the extract and subjected to structural identification.

Description

technical field [0001] The invention belongs to the field of active ingredient extracts of traditional Chinese medicines, in particular to a traditional Chinese medicine extract, especially to a preparation method of Acanthopanax radix Polygonatum leaf extract for improving sleep and lowering blood sugar, and the invention also relates to the effect of the extract on improving sleep and lowering blood sugar in the application. Background technique [0002] Insomnia, also known as sleep and sleep maintenance disorders, refers to the inability to fall asleep or maintain a sleep state, resulting in insufficient sleep. According to different causes, insomnia can be divided into primary insomnia and secondary insomnia. Primary insomnia usually lacks a clear etiology, and mainly includes three types: psychophysiological insomnia, idiopathic insomnia, and subjective insomnia. The diagnosis of primary insomnia is primarily a diagnosis of exclusion. Primary insomnia can be conside...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8969A61K31/704A61P25/20A61P3/10C07J63/00A61K127/00
CPCA61K9/1652A61K9/2059A61K9/4866A61K31/704A61K36/254A61K36/8969A61K2236/333A61K2236/39A61K2236/51A61K2236/55C07J63/008
Inventor 王知斌姜海杨春娟翟春梅刘华薛娟
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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