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Organic polymeric photon up-conversion nanoparticles for biological applications

A nanoparticle, polymeric technology, applied in the field of oxygen and other substances that will affect the upconversion process, pressure, temperature perception, and organic photon upconversion nanoparticles, can solve the problems that cannot affect the ratio of wavelengths, low efficiency, etc.

Inactive Publication Date: 2016-07-06
SONY CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the inorganic matrix UCP (usually the UC system itself) and the TPA-based particles are only sensitive to high-intensity monochromatic lasers (usually kW / cm 2 level) to function and requires a very high spectral energy density of the excitation light source (typically Wnm -1 grade), moreover they have low efficiency (so far only about 1% to up to 4% have been reported for crystalline powders, but they have efficiency only for high strength) (Page et al., 1998, J.Opt.Soc.Am.B , Vol.15, No.3, 996)
Furthermore, the systems reported so far only have emission properties intrinsic to the corresponding materials used, but cannot influence the ratio of emitted wavelengths

Method used

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  • Organic polymeric photon up-conversion nanoparticles for biological applications
  • Organic polymeric photon up-conversion nanoparticles for biological applications
  • Organic polymeric photon up-conversion nanoparticles for biological applications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0114] Sensitizer molecule (or "sensitizer component")

[0115] A "sensitizer" is a molecule capable of absorbing light, and the sensitizer is an organic dye or a metal-organic complex, preferably triplet-rich.

[0116] A metal-organic complex is defined as a compound comprising at least a metal M surrounded by one or more molecules, so-called ligands L, usually bound to the metal ion by coordinate-covalent bonds.

[0117] Ligands are cyclic or acyclic, aromatic or nonaromatic, monodentate or polydentate organic molecules.

[0118] In cases where the ligand is an amplified aromatic system, the ligand itself is the organic dye sensitizer without being bound to the metal.

[0119] For a better understanding, both Pd-porphyrins (=metal-organic complexes) and metal-free porphyrins (=organic molecules) are sensitizers.

[0120]

[0121] Metal organic complexes can be:

[0122] -Has the general formula ML m single core,

[0123] Wherein m is the number of ligands, m=1-8, p...

Embodiment 1

[0321] Embodiment 1: Preparation of nanoparticles

[0322] An amphiphilic block copolymer as a stabilizer, a polymer as a polymeric organic matrix component, and at least two organic dyes (5×10 -5 Sensitizer for M, 5 x 10 -4 M) was dissolved in THF (tetrahydrofuran), and the resulting solution (volume: 10 ml) was stirred for 2 hours. Then, pour 40ml of MilliQ water all at once (within 1 s) to add 40ml of the above water. Other possible methods of mixing with the aqueous phase have been outlined above. The solution was stirred overnight (or up to 48 hours), then filtered under vacuum through No. 1 Whatman filter paper. Thereafter, first THF and then water were removed using a vacuum rotary evaporator, and the residue was dried in vacuo for another 2 hours. Subsequently, 40 ml of MilliQ water were added and the solution was stirred overnight, then dewatered and dried as described above. Finally, the residue was dissolved in 10 ml MilliQ water (resulting in a homogeneous n...

Embodiment 2

[0372] Example 2: Upconverting Emission from Nanoparticles

[0373] Nanoparticles (NP) according to the present invention were dispersed in water and excited with different intensities of 633 nm light. Figure 3A , 4A and 5 respectively represent the emission spectrum of the nanoparticles (=nanoparticle 1 of = embodiment 1) that adopts perylene as the emitter, and the emission spectrum of the nanoparticles (=nanoparticle 3 of = embodiment 1) that adopts BPEA as the emitter; And the emission spectrum of the nanoparticles (=nanoparticle 2 of Example 1) using PhP as emitter. In all three cases, the spectra indicated even 2 High-efficiency upconversion (peak at ~480nm, = blue light) is still present at excitation intensities of

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Abstract

The present invention relates to organic polymeric photon up-conversion nanoparticles for biological applications, such as labeling and / or detection of cells, biological (macro-) molecules or other analytes, as well as for sensing temperature, pressure, oxygen and other substances that influence the up-conversion process. It further relates to organic photon up-conversion nanoparticles for singlet oxygen generation and the treatment of diseases, such as cancer.

Description

[0001] This application is a divisional application of a patent application with an application date of May 31, 2010, an application number of 201010195191.3, and an invention title of "Organic Polymerized Photon Up-Conversion Nanoparticles for Biological Applications", the entire content of which is hereby incorporated Reference. technical field [0002] The present invention relates to an organic polymeric photon up-conversion nanoparticle (photonup-conversion nanoparticle) for biological applications, such as for labeling and / or detection of cells, biological (macro)molecules or other analytes, and for sensing temperature , pressure, oxygen, and other substances that can affect the upconversion process. The present invention further relates to an organic photon upconversion nanoparticle for singlet oxygen generation and for the treatment of diseases such as cancer. Background technique [0003] It has been observed in many systems that illumination with longer wavelength...

Claims

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Application Information

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IPC IPC(8): A61K49/00
CPCA61K49/0093A61K31/555A61K31/015A61P35/00
Inventor 特森卡·米特瓦格达·福尔曼加布里埃尔·内尔斯弗拉基米尔·亚库肯斯坦尼斯拉维·布劳斥维
Owner SONY CORP
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