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Protopanoxadiol submicroemulsion preparation as well as preparation method and application thereof

A technology of protopanaxadiol and milk preparations, which is applied in the fields of pharmaceutical formulations, emulsion delivery, and medical preparations containing active ingredients, and can solve problems that have not yet been discovered

Inactive Publication Date: 2016-07-13
许庆彤
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The present invention has been searched for patents and documents, and no report has been found on the preparation of PPD into emulsion for injection to carry out anti-tumor research.

Method used

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  • Protopanoxadiol submicroemulsion preparation as well as preparation method and application thereof
  • Protopanoxadiol submicroemulsion preparation as well as preparation method and application thereof
  • Protopanoxadiol submicroemulsion preparation as well as preparation method and application thereof

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Embodiment 1

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[0026]

[0027]

Embodiment 2

[0029]

Embodiment 3

[0031] prescription:

[0032]

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Abstract

The invention provides a protopanoxadiol submicroemulsion preparation and a preparation method thereof. The protopanoxadiol submicroemulsion preparation comprises protopanoxadiol, oil, an emulsifier and a co-emulsifier, average particle size of the protopanoxadiol submicroemulsion preparation is 110-130nm, and Zeta potential ranges from -40mV to -20mV. The invention also provides an application of the protopanoxadiol submicroemulsion preparation in preparation of a medicine with the effects of promoting hematopoietic cell proliferation and alleviating bone marrow inhibiting effect caused by tumour treatment.

Description

technical field [0001] The invention relates to a protopanaxadiol submicroemulsion preparation, a preparation method and application thereof, and belongs to the field of pharmaceutical preparations. Background technique [0002] Protopanaxadiol (PPD) is a diol-type ginsenoside, mainly derived from Araliaceae plants such as Panax ginseng, American ginseng, and Panax notoginseng. It is the aglycone of ginsenosides in the diol group, and also the final product of ginsenosides in the diol group after microbial fermentation. Studies have shown that PPD has many activities such as inhibiting the growth of various tumors, antidepressant, activating chloride ion channels, inhibiting the depolarization of activated sodium channels, inhibiting the growth of human embryonic kidney cells HEK-293 cells and the growth of Helicobacter pylori. At the same time, PPD has a protective effect on cognitive impairment. [0003] PPD is a lipophilic compound with poor solubility in water, low ora...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/575A61K47/44A61P7/06A61P7/00
CPCA61K9/1075A61K31/575A61K47/44
Inventor 赵树民廖永红杨飞飞周晶
Owner 许庆彤
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