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A kind of preparation method of mip magnetic mesoporous silicon-based microsphere
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A mesoporous silicon and magnetic technology, which is applied in the field of preparation of MIP magnetic mesoporous silicon-based microspheres, can solve problems such as difficult separation and achieve the effect of speeding up the reaction rate.
Active Publication Date: 2018-05-29
GUANGDONG ENG TECH INST
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Problems solved by technology
These molecularly imprinted polymers have high selective adsorption efficiency, but are difficult to separate from the solution. If these molecularly imprinted polymers are constructed on magnetic mesoporous silica microspheres, the above problems will be effectively solved
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Embodiment 1
[0035] A method for preparing MIP magnetic mesoporous silicon-based microspheres, the preparation steps are as follows:
[0036] A. Preparation of ractopamine surface molecularly imprinted materials;
[0037] B, choose methacrylic acid as functional monomer, ractopamine as template, ethylene glycol dimethacrylate as crosslinking agent, the proportioning of described template, functional monomer and crosslinking agent is 1:6:30 , adding the template, the functional monomer and the crosslinking agent to the solution of dimethyl sulfoxide and mixing to carry out the polymerization reaction;
[0038] C. Mix and stir the template, functional monomer and cross-linking agent in the solution for 2 hours to form a mixed solution of imprinted molecules and functional monomer;
[0039] D, the above-mentioned mixed solution-made is deoxygenated by nitrogen, and the nitrogen time is 20 minutes;
[0040] E. Add 3.8 to 4.2 μmol of 1,1,4,7,7-pentamethyldivinyltriamine and 1.5 to 2 μmol of m...
Embodiment 2
[0052] A. Preparation of ractopamine surface molecularly imprinted materials;
[0053] B, choose methacrylic acid as functional monomer, ractopamine as template, ethylene glycol dimethacrylate as crosslinking agent, the proportioning of described template, functional monomer and crosslinking agent is 1:6:30 , adding the template, the functional monomer and the crosslinking agent to the solution of dimethyl sulfoxide and mixing to carry out the polymerization reaction;
[0054] C. Mix and stir the template, functional monomer and cross-linking agent in the solution, and the stirring time is 1.5 small , forming a mixed solution of imprinted molecules and functional monomers;
[0055] D, the mixed solution that above-mentioned makes is carried out deoxygenation by nitrogen, and nitrogen time is 15 minutes ;
[0056] E. Add 3.8 to 4.2 μmol of 1,1,4,7,7-pentamethyldivinyltriamine and 1.5 to 2 μmol of metal organocatalyst cuprous bromide in mixed solution one after passing nitro...
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Abstract
The invention discloses a preparation method of MIP (molecular imprinted polymer) magnetic mesoporous silica-based microspheres. According to the method, a ractopamine MIP is constructed by polymerizing surface-initiated atom transfer radicals on magnetic mesoporous silica-based microspheres, sodium citrate modified Fe3O4 magnetofluid is taken as a core, mesoporous silica spheres are prepared through hydrolysis and self-assembly of tetraethyl orthosilicate and octadecyltrimethoxysilane with long carbon chains, and the magnetic mesoporous silica-based microspheres with submicron particle size are obtained; further, the surfaces of prepared magnetic mesoporous silica-based microspheres are modified with an ATRP (atom transfer radical polymerization) initiator, then the modified magnetic mesoporous silica-based microspheres are taken as a reactor, the ractopamine MIP is generated in mesopores through adsorption, and the MIP magnetic mesoporous silica-based microspheres which can be used for separating and enriching trace substances are formed and have higher adsorption capacity and better selection for ractopamine and similar drugs of ractopamine.
Description
technical field [0001] The invention relates to a silicon-based nanometer adsorption material, in particular to a preparation method of MIP magnetic mesoporous silicon-based microspheres. Background technique [0002] Molecular imprinting technology can design and construct a three-dimensional cavity system that can specifically recognize target molecules. Related studies have shown that quite a few studies use molecularly imprinted polymers (Molecular Imprinted Polymers, MIPs) of ractopamine (RAC) as adsorbents. These molecularly imprinted polymers have high selective adsorption efficiency, but are difficult to separate from the solution. If these molecularly imprinted polymers are constructed on magnetic mesoporous silica microspheres, the above problems will be effectively solved. [0003] Mesoporous materials are characterized by large specific surface area, adjustable pore size, and a large number of silanol groups on the surface, which are easy to further modify and m...
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