A kind of preparation method of mip magnetic mesoporous silicon-based microsphere

Abstract

The invention discloses a preparation method of MIP (molecular imprinted polymer) magnetic mesoporous silica-based microspheres. According to the method, a ractopamine MIP is constructed by polymerizing surface-initiated atom transfer radicals on magnetic mesoporous silica-based microspheres, sodium citrate modified Fe3O4 magnetofluid is taken as a core, mesoporous silica spheres are prepared through hydrolysis and self-assembly of tetraethyl orthosilicate and octadecyltrimethoxysilane with long carbon chains, and the magnetic mesoporous silica-based microspheres with submicron particle size are obtained; further, the surfaces of prepared magnetic mesoporous silica-based microspheres are modified with an ATRP (atom transfer radical polymerization) initiator, then the modified magnetic mesoporous silica-based microspheres are taken as a reactor, the ractopamine MIP is generated in mesopores through adsorption, and the MIP magnetic mesoporous silica-based microspheres which can be used for separating and enriching trace substances are formed and have higher adsorption capacity and better selection for ractopamine and similar drugs of ractopamine.

Description

technical field

[0001] The invention relates to a silicon-based nanometer adsorption material, in particular to a preparation method of MIP magnetic mesoporous silicon-based microspheres. Background technique

[0002] Molecular imprinting technology can design and construct a three-dimensional cavity system that can specifically recognize target molecules. Related studies have shown that quite a few studies use molecularly imprinted polymers (Molecular Imprinted Polymers, MIPs) of ractopamine (RAC) as adsorbents. These molecularly imprinted polymers have high selective adsorption efficiency, but are difficult to separate from the solution. If these molecularly imprinted polymers are constructed on magnetic mesoporous silica microspheres, the above problems will be effectively solved.

[0003] Mesoporous materials are characterized by large specific surface area, adjustable pore size, and a large number of silanol groups on the surface, which are easy to further modify and m...