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Freeze-dry composition for treating NHL (non-hodgkin lymphoma) and preparation method thereof

A non-Hodgkin, composition technology, applied in the field of medicine, can solve the problems of inconvenience, increase the risk of use by patients, etc., and achieve the effects of improving safety and stable quality

Inactive Publication Date: 2016-07-20
QINGDAO TUMOR HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] But the contriver finds in the test, needs to use 0.9% sodium chloride solution to dilute after intravenous infusion during clinical use of injection picantron maleate, and the visible foreign matter of its diluted solution increases with the prolongation of placement time, and this It brings great inconvenience to the clinical drug preparation of medical staff, and also increases the risk of use of patients. The inventor found through the investigation of the current technology that none of the current technologies can solve this problem.

Method used

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  • Freeze-dry composition for treating NHL (non-hodgkin lymphoma) and preparation method thereof
  • Freeze-dry composition for treating NHL (non-hodgkin lymphoma) and preparation method thereof
  • Freeze-dry composition for treating NHL (non-hodgkin lymphoma) and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] prescription

[0018]

[0019] Preparation Process

[0020] Weigh the prescribed amount of sodium chloride, lactose and sodium acetate and dissolve them in an appropriate amount of water for injection, weigh the prescribed amount of picantone maleate and dissolve them in the above solution, stir and mix evenly, and dissolve them with an appropriate amount of dilute hydrochloric acid or dilute hydrogen The sodium oxide solution is used to adjust the pH value, and the volume is adjusted to the total amount with water for injection, stirred and mixed evenly, filtered, filled, freeze-dried, and the finished product is obtained by visual inspection.

Embodiment 2

[0022] prescription

[0023]

[0024] Preparation Process:

[0025] Weigh the prescribed amount of sodium chloride, lactose and sodium acetate and dissolve them in an appropriate amount of water for injection, weigh the prescribed amount of picantone maleate and dissolve them in the above solution, stir and mix evenly, and dissolve them with an appropriate amount of dilute hydrochloric acid or dilute hydrogen The sodium oxide solution is used to adjust the pH value, and the volume is adjusted to the total amount with water for injection, stirred and mixed evenly, filtered, filled, freeze-dried, and the finished product is obtained by visual inspection.

Embodiment 3

[0027] prescription

[0028]

[0029] Preparation Process:

[0030] Weigh the prescribed amount of sodium chloride, lactose and sodium acetate and dissolve them in an appropriate amount of water for injection, weigh the prescribed amount of picantone maleate and dissolve them in the above solution, stir and mix evenly, and dissolve them with an appropriate amount of dilute hydrochloric acid or dilute hydrogen The sodium oxide solution is used to adjust the pH value, and the volume is adjusted to the total amount with water for injection, stirred and mixed evenly, filtered, filled, freeze-dried, and the finished product is obtained by visual inspection.

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Abstract

The invention belongs to the technical field of medicine, and particularly relates to a freeze-dry composition for treating NHL (non-hodgkin lymphoma) and a preparation method thereof. The freeze-dry composition for treating NHL mainly consists of active ingredients including maleic acid pixantrone, sodium chloride, lactose, natrium aceticum and pH regulators. The The freeze-dry composition for treating NHL has the advantages that the quality is stable; all indexes conform to the quality requirements; in the clinical use process, the preparation by medical personnel is convenient; the prepared medicine can be stored for a long time; meanwhile, the use safety of a patient is also improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a freeze-dried composition for treating non-Hodgkin's lymphoma and a preparation method thereof. Background technique [0002] Non-Hodgkin's lymphoma (NHL) is a group of highly heterogeneous neoplastic diseases. Due to the different functions of clonal proliferating lymphocytes and their wide distribution in the human body, they can affect any organ in the body, so they show various morphological characteristics, immunophenotypes, biological behaviors, clinical manifestations, different treatment responses and prognosis. Its main clinical features are superficial or deep lymphadenopathy, hyperplasia of extranodal lymphoid tissue, involvement of other organs in the body, and systemic symptoms. The course of NHL progresses at different speeds. Most patients present with multifocal malignant hyperplasia at onset, or initially originate from a group of lymph nodes or a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/473A61K47/26A61P35/00
CPCA61K9/0019A61K9/19A61K31/473A61K47/26
Inventor 夏建明
Owner QINGDAO TUMOR HOSPITAL
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