Unlock instant, AI-driven research and patent intelligence for your innovation.

Method for preparing pharmaceutical adjuvant Eudragit E100 microparticles

A technology of pharmaceutical excipients and microparticles, which is used in pharmaceutical formulations, microcapsules, and medical preparations with inactive ingredients, etc., to reduce side reactions, improve contact and action time, and stabilize and effectively treat blood drug concentrations.

Inactive Publication Date: 2016-07-20
HANGZHOU INST OF ADVANCED MATERIAL BEIJING UNIV OF CHEM TECH
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among various microencapsulation technology methods, it is a new challenge to prepare drug particles with small particle size and uniform distribution

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for preparing pharmaceutical adjuvant Eudragit E100 microparticles
  • Method for preparing pharmaceutical adjuvant Eudragit E100 microparticles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0011] Preparation of EudragitE100 spherical microparticles.

[0012] In this example, EudragitE100 polymer spherical particles are prepared through the rapid expansion process of supercritical fluid solution. Among them, the device for preparing particles is a supercritical fluid solution rapid expansion process (RESS) device, such as figure 1 shown.

[0013] (1) First weigh 100 mg of EudragitE100 and dissolve it in 10 ml of acetone solvent, then add a certain mass of PVP to fully dissolve.

[0014] (2) The temperature in the water bath is controlled by the heater, accurate to ±0.1℃. CO provided by gas cylinder 2 It is injected into the whole device by the plunger pump, and then the pressure of the system is controlled by the ISCO pump. After rising to the set pressure, the accuracy is ±0.1MPa, and the device pressure and temperature are stabilized for 30min.

[0015] (3) Then, under the condition that the pressure of the system controlled by the ISCO pump remains unchang...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for preparing pharmaceutical adjuvant Eudragit E100 microparticles. A solution of a polymer Eudragit E100 (A) added with a dispersant-polyvinylpyrrolidone (B) is treated with a rapid expansion process of a supercritical fluid solution to obtain polymer microparticles. The method is suitable for preparing a gastric-soluble micro-particulate medicine preparation. Based on the conditions of the method for preparing the microparticles from the gastric-soluble packing material Eudragit E100 of the pharmaceutical adjuvant, a medicine can be micronized (capsuled), the side effects of the medicine and the frequency of taking the medicine can be reduced, and the utilization rate of the medicine in vivo can be increased.

Description

technical field [0001] The present invention relates to a method for preparing polymer particles of gastric dissolving coating material in the field of medicine. Background technique [0002] Microencapsulation of drugs is to use natural or synthetic pharmaceutical polymer materials as capsule materials to disperse or encapsulate drugs in materials to form particles. Due to the small particle size of the drug particles and easy adhesion, the contact area and contact time between the drug and the action site can be increased, and the bioavailability is high; it can also be used by modifying the surface of the drug particles and combining with other pharmaceutical polymers. A drug release system capable of timing and positioning is prepared. Due to its huge application prospects and changes to traditional drug delivery methods, this research field has received extensive attention from scholars at home and abroad in recent years. In various microencapsulation techniques, it i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K9/16A61K47/32
CPCA61K9/1635A61K9/5026A61K47/32
Inventor 甄崇礼王辉卢建红
Owner HANGZHOU INST OF ADVANCED MATERIAL BEIJING UNIV OF CHEM TECH