Synthesis method of m-nitrobenzaldehyde

Abstract

The invention provides a synthesis method of m-nitrobenzaldehyde. The method comprises the following steps: firstly, reacting, concretely carrying out reaction on copper nitrate, water, silver nitrate and benzaldehyde in a molar ratio of (1.03-1.1):(20-40):(0.001-0.0012):1.0, so that reaction mixture is obtained; secondly, preparing an m-nitrobenzaldehyde crude product, concretely, filtering while the reaction mixture is hot, so as to obtain mother liquor, and then cooling the mother liquor, filtering, and taking solid, so that the m-nitrobenzaldehyde crude product is obtained; and thirdly, preparing high-purity m-nitrobenzaldehyde, concretely, adding a water soluble solvent into the m-nitrobenzaldehyde crude product, filtering, and drying, so that high-purity m-nitrobenzaldehyde is obtained. By adopting the method provided by the invention, molar yield of the obtained m-nitrobenzaldehyde is more than 90%, chromatographic purity is more than 99.8%, and content of o-nitrobenzaldehyde is less than 0.1%; and fewer three wastes are produced in a production process, so that the method provided by the invention is environmentally friendly.

Description

Technical field [0001] The invention relates to the technical field of organic compound synthesis, and in particular to a method for synthesizing m-nitrobenzaldehyde. Background technique [0002] m-nitrobenzaldehyde is a very important pharmaceutical intermediate, widely used in the synthesis of a variety of medicines, such as closulon, cilnidipine, nitrendipine, nimodipine, etc. At present, there are very few domestic manufacturers. The reason is that the existing production process is complicated, the ortho-para selectivity is poor, and multiple recrystallizations are required to obtain qualified products. High-purity products are not high and the amount of waste is large, which is very destructive to the environment. big. [0003] Currently, the method for preparing m-nitrobenzaldehyde is as follows: [0004] Ding Chengrong and others published an article in the "Journal of Zhejiang University of Technology" in 2005 titled "Research on a New Synthesis Process of m-Nitr...

AI Technical Summary

Problems solved by technology

Although this method has a very high yield, it also has the following disadvantages: the process steps are long, the production cost is very high, and the amount of waste water produced is very large, and there is also a large amount of nitrate and sulfite in the waste water, which is harmful to the environment. Very big

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