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Establishment of stress cardiomyopathy animal model

A technology of animal model and establishment method, applied in medical science, veterinary equipment, veterinary surgery, etc., can solve problems such as coronary angiography stenosis

Inactive Publication Date: 2016-08-17
郭瑞威
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are often mental or physical stress events before the onset, or due to the onset or aggravation of other physical diseases, and the time from the stress to onset ranges from a few minutes to several hours. Severe chest pain, retrosternal compression, and breathing similar to acute coronary syndrome occur. Difficulty and syncope, some patients present with heart failure as the first symptom, but coronary angiography does not reveal meaningful stenosis

Method used

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  • Establishment of stress cardiomyopathy animal model
  • Establishment of stress cardiomyopathy animal model
  • Establishment of stress cardiomyopathy animal model

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The invention discloses a method for establishing an animal model of stress cardiomyopathy, comprising the following steps:

[0019] Preoperative preparation: preparation of instruments, pentobarbital sodium anesthetic, experimental rabbits, 4 blank control groups, 4 experimental groups, 4 losartan drug interference, 4 enalapril drug interference, respectively. The numbers are 1, 2, 3, 4; intravenous anesthesia injection, observe the anesthesia reaction;

[0020] Perform the operation: fix the anesthetized experimental rabbit on the operating table, cut off the hair on the neck to expose the skin, disinfect it with alcohol three times, and spread the hole towel; cut the skin, separate the fascia, cut the muscle layer, pick Out of the vagus nerve;

[0021] Vagus nerve stimulation: Clamp the two ends of the nerve with two clips of a 1.5V stimulation instrument, cover the cut tissue with gauze soaked in saline, turn on the power switch, and turn off the power after 2 minu...

Embodiment 2

[0024] Experimental purpose and method: To evaluate the effect of animal model establishment, the method is to conduct electrocardiogram and tissue slice detection and observation on the experimental group and the blank control group.

[0025] Experimental results: if Figure 1-3 As shown, the heart rates of the experimental group and the blank control group were 300 and 230 beats per minute, respectively, which can explain that the reflex after electrical stimulation causes sympathetic nerve excitement and thus causes the heart rate to increase; The myocardium is thinned, the structure of the myocardium is disordered, and there are tissue changes such as myocardial rupture and vacuole between the myocardium.

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Abstract

The invention relates to the field of animal model establishment, and discloses a method for establishing an animal model of stress cardiomyopathy, including preoperative preparation, operation, vagus nerve stimulation and postoperative suturing, by studying the blank group, experimental group, ARB class Drug interference, ACEI drugs, studied the induction of cardiomyopathy under drug-induced and electrical stimulation, and performed pathological characterization to verify the successful establishment of animal models to solve the problem that there is currently no suitable animal model of stress cardiomyopathy available problem in research.

Description

technical field [0001] The invention relates to the field of establishing animal models, in particular to a method for establishing animal models of stress cardiomyopathy. Background technique [0002] Stress cardiomyopathy, also known as apical ballooning syndrome, is also named Tako-Tsubo syndrome or Tako because the shape of the left ventricle at the end of systole resembles the fish baskets used by Japanese fishermen to catch octopus - Tsubo cardiomyopathy. Stress cardiomyopathy was first reported by Sato et al. in 1990. Its main feature is transient apical wall motion abnormality, showing ballooning change. Different from the progressive expansion of the ventricles in dilated cardiomyopathy, the ventricular enlargement and abnormal wall motion in stress cardiomyopathy are reversible, and the prognosis is good. It mainly occurs in middle-aged and elderly women after menopause. There are often mental or physical stress events before the onset, or due to the onset or a...

Claims

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Application Information

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IPC IPC(8): A61D1/00
CPCA61D1/00
Inventor 郭瑞威刘蓓杨丽霞奚银燕
Owner 郭瑞威
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