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A kind of pharmaceutical composition and its application for the treatment of gastric ulcer

A composition and gastric ulcer technology, applied in the field of medicine, can solve problems such as poor treatment effect and large side effects, and achieve the effects of improving medication safety and reducing bleeding risk

Active Publication Date: 2018-11-20
黑龙江省诺林医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the technical deficiencies of relatively large side effects and poor therapeutic effect of existing drugs for treating gastric ulcer, the invention provides a pharmaceutical composition for treating gastric ulcer, which is composed of esomeprazole strontium and quercetin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The preparation of embodiment 1 compound tablet

[0019] Quercetin

[0020] Preparation process: Mix quercetin and esomeprazole strontium with auxiliary materials microcrystalline cellulose and starch evenly, add appropriate amount of 15% starch slurry to make soft material, and then granulate through a 16-mesh sieve. Dry the wet granules at 60°C, pass the dry granules through a 16-mesh sieve for granulation, sieve out the fine powder in the dry granules, mix with magnesium stearate, and then mix with the dry granules, and press into tablets to obtain the product.

Embodiment 2

[0021] The preparation of embodiment 2 compound tablet

[0022] Quercetin

[0023] Preparation process: except that the components are different, the preparation process is the same as that described in Example 1.

Embodiment 3

[0024] The preparation of embodiment 3 compound dispersible tablets

[0025] Quercetin

[0026] Preparation process: weigh quercetin and esomeprazole strontium according to the prescription, use microcrystalline cellulose as filler, croscarmellose sodium and polyvinylpyrrolidone as disintegrants, 5% PVP 60% The ethanol solution is used as the binder, the micropowdered silica gel is used as the flow aid, and it is granulated by a fluidized bed in one step, and then compressed into tablets.

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PUM

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Abstract

The invention relates to a pharmaceutical composition for treating gastric ulcers and application thereof, and belongs to the technical field of medicine. For overcoming the technical defects that existing medicine for treating gastric ulcers is large in side effect and poor in treatment effect, the pharmaceutical composition for treating gastric ulcers is provided and is prepared from esomeprazole strontium and quercetin; the two pharmaceutical active components have a significant synergistic effect in treating and inhibiting gastric ulcers, and thus a good treatment effect on gastric ulcers is achieved.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating gastric ulcer and its application, belonging to the technical field of medicine. Background technique [0002] Peptic ulcer (PU) mainly refers to chronic ulcers that occur in the stomach and duodenum, that is, gastric ulcer and duodenal ulcer, and can also occur in the lower end of the esophagus, near the gastroduodenal anastomosis and Meckel's diverticulum. Western medicine classifies it as a localized tissue defect that can involve the mucosa, submucosa, and muscle layer. Traditional Chinese medicine classifies it as "epigastric pain" based on its clinical symptoms. The disease has a long course of disease, repeated attacks, and complex clinical manifestations. It is a common chronic gastrointestinal disease worldwide. It has been reported that peptic ulcer accounts for 10.3% to 2.6% of the domestic gastroscopy population. The disease can be seen at any age, most of which are 20-50...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4439A61K31/352A61P1/04
CPCA61K31/352A61K31/4439A61K2300/00
Inventor 孔庆新李思阳樊鑫梅成良钰王宣
Owner 黑龙江省诺林医药有限公司
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