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Drug composition for preventing and treating gastric ulcer and its application

A composition and gastric ulcer technology, applied in the field of medicine, can solve problems such as poor treatment effect and large side effects, and achieve the effects of improving medication safety and reducing bleeding risk

Inactive Publication Date: 2017-06-27
张美荣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the technical deficiencies of relatively large side effects and poor therapeutic effect of the existing drugs for treating gastric ulcer, the present invention provides a pharmaceutical composition for treating gastric ulcer, which is composed of clobopride malate and agaricin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The preparation of embodiment 1 compound tablet

[0021] Qinlong Kusu 1g Clobopride Malate 10g microcrystalline cellulose 45g starch 30g 15% starch slurry Appropriate amount Magnesium stearate 2.0g

[0022] Preparation process: mix draconidin and clobopride malate with auxiliary materials microcrystalline cellulose and starch evenly, add an appropriate amount of 15% starch slurry to make soft material, and then granulate through a 16-mesh sieve. Dry the wet granules at 60°C, pass the dry granules through a 16-mesh sieve for granulation, sieve out the fine powder in the dry granules, mix with magnesium stearate, and then mix with the dry granules, and press into tablets to obtain the product.

Embodiment 2

[0023] The preparation of embodiment 2 compound tablet

[0024] Qinlong Kusu 10g Clobopride Malate 1g compressible starch 90g lactose 50g 15% starch slurry Appropriate amount Micropowder silica gel 1.5g

[0025] Preparation process: except that the components are different, the preparation process is the same as that described in Example 1.

Embodiment 3

[0026] The preparation of embodiment 3 compound dispersible tablets

[0027] Qinlong Kusu 10g Clobopride Malate 2g Croscarmellose Sodium 12g microcrystalline cellulose 160g Polyvinylpyrrolidone 6g 5% PVP 60% ethanol solution Appropriate amount Micropowder silica gel 5g

[0028] Preparation process: Weigh draconidin and clobopride malate according to the prescription, use microcrystalline cellulose as filler, croscarmellose sodium and polyvinylpyrrolidone as disintegrants, 5% PVP 60 The % ethanol solution is used as a binder, the micropowdered silica gel is used as a flow aid, and it is granulated by a fluidized bed in one step, and then compressed into tablets.

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PUM

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Abstract

The invention relates to a drug composition for preventing and treating gastric ulcer and its application, and belongs to the technical field of medicine. In order to overcome the shortcomings of big side effect and poor treatment effect of the drug for treating gastric ulcer, the invention provides the drug composition for preventing and treating gastric ulcer; the drug composition is composed of clebopride malate and Qinlongkusu. The active components of the two drugs have significant synergistic effect to treat and inhibit gastric ulcer, thereby well treating the gastric ulcer. On this basis, the radix ophiopogonis extractive is jointly used, so that the treatment effect of the drug composition to gastric ulcer is significantly enhanced, the toxic side effect thereof is obviously reduced, and the drug compliance of a patient is improved.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing and treating gastric ulcer and its application, belonging to the technical field of medicine. Background technique [0002] Peptic ulcer (PU) mainly refers to chronic ulcers that occur in the stomach and duodenum, that is, gastric ulcer and duodenal ulcer, and can also occur in the lower end of the esophagus, near the gastroduodenal anastomosis and Meckel's diverticulum. Western medicine classifies it as a localized tissue defect that can involve the mucosa, submucosa, and muscle layer. Traditional Chinese medicine classifies it as "epigastric pain" based on its clinical symptoms. The disease has a long course of disease, repeated attacks, and complex clinical manifestations. It is a common chronic gastrointestinal disease worldwide. It has been reported that peptic ulcer accounts for 10.3% to 2.6% of the domestic gastroscopy population. The disease can be seen at any age, most of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61K31/7048A61K31/4468A61P1/04
CPCA61K36/8968A61K31/4468A61K31/7048A61K2236/331A61K2236/333A61K2236/51A61K2300/00
Inventor 张美荣
Owner 张美荣
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