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A kind of pharmaceutical composition and its application for the treatment of gastric ulcer

A composition and gastric ulcer technology, applied in the field of medicine, can solve problems such as poor therapeutic effect and large side effects, and achieve the effect of improving drug safety and reducing the risk of bleeding

Inactive Publication Date: 2018-09-14
HENAN UNIV HUAIHE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to overcome the technical deficiency of relatively large side effects and poor therapeutic effect of existing drugs for treating gastric ulcer, the present invention provides a pharmaceutical composition for treating gastric ulcer, which is composed of vonoprazan fumarate and catalpol

Method used

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  • A kind of pharmaceutical composition and its application for the treatment of gastric ulcer
  • A kind of pharmaceutical composition and its application for the treatment of gastric ulcer
  • A kind of pharmaceutical composition and its application for the treatment of gastric ulcer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The preparation of embodiment 1 compound tablet

[0021]

[0022] Preparation process: mix catalpol and vonorazan fumarate with auxiliary materials microcrystalline cellulose and starch evenly, add appropriate amount of 15% starch slurry to make soft material, and pass through a 16-mesh sieve to granulate. Dry the wet granules at 60°C, pass the dry granules through a 16-mesh sieve for granulation, sieve out the fine powder in the dry granules, mix with magnesium stearate, and then mix with the dry granules, and press into tablets to obtain the product.

Embodiment 2

[0023] The preparation of embodiment 2 compound tablet

[0024]

[0025]

[0026] Preparation process: except that the components are different, the preparation process is the same as that described in Example 1.

Embodiment 3

[0027] The preparation of embodiment 3 compound dispersible tablet

[0028]

[0029] Preparation process: Weigh catalpol and vonoprazan fumarate according to the prescription, use microcrystalline cellulose as filler, croscarmellose sodium and polyvinylpyrrolidone as disintegrants, 5% PVP 60% The ethanol solution is used as the binder, the micropowdered silica gel is used as the flow aid, and it is granulated by a fluidized bed in one step, and then compressed into tablets.

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Abstract

The invention belongs to the technical field of medicines and relates to a pharmaceutical composition for treatment of gastric ulcer and application of the pharmaceutical composition for treatment of gastric ulcer. The pharmaceutical composition for treatment of gastric ulcer is provided to overcome technical defects of strong side effects and poor efficacies of existing medicines for treating gastric ulcer and is composed of vonoprazan fumarate and catalpol. The two medicinal active components have a remarkable synergistic effect in treatment and inhibition of gastric ulcer. Therefore, the pharmaceutical composition has an excellent treatment effect on gastric ulcer.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating gastric ulcer and its application, belonging to the technical field of medicine. Background technique [0002] Peptic ulcer (PU) mainly refers to chronic ulcers that occur in the stomach and duodenum, that is, gastric ulcer and duodenal ulcer, and can also occur in the lower end of the esophagus, near the gastroduodenal anastomosis and Meckel's diverticulum. Western medicine classifies it as a localized tissue defect that can involve the mucosa, submucosa, and muscle layer. Traditional Chinese medicine classifies it as "epigastric pain" based on its clinical symptoms. The disease has a long course of disease, repeated attacks, and complex clinical manifestations. It is a common chronic gastrointestinal disease worldwide. It is reported that peptic ulcer accounts for 10.3% to 2.6% of the domestic gastroscopy population. The disease can be seen at any age, mostly between 20 and 50 year...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K31/4439A61P1/04
CPCA61K31/4439A61K31/7048A61K2300/00
Inventor 葛全兴林旭红王传秀
Owner HENAN UNIV HUAIHE HOSPITAL
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