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Novel mechanism for promoting human tumor generation and development

A mechanism and tumor technology, applied in the field of biomedicine, can solve the problems of low ATP quantity, high glucose uptake rate, high metabolite lactic acid content, etc.

Inactive Publication Date: 2016-08-31
余祖江
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Problems solved by technology

It is manifested by high glucose uptake rate, active glycolysis, and high content of metabolite lactic acid. Although glycolysis consumes more glucose, the amount of ATP produced is relatively small

Method used

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  • Novel mechanism for promoting human tumor generation and development
  • Novel mechanism for promoting human tumor generation and development
  • Novel mechanism for promoting human tumor generation and development

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[0031] Case 1: Li XX, a 65-year-old female, was found to be HBsAg positive for 10 years. She started oral lamivudine antiviral treatment 6 years ago. During this period, she was regularly reexamined and her condition was stable. 20 days ago, due to fatigue and poor appetite, the local hospital reexamination indicated that the virus He rebounded, and the liver enzymes increased, so he was admitted to our hospital for treatment on November 17, 2015. The next day's reexamination results showed: hepatitis B and three yang, HBV-DNA: 1.33×10 4 Iu / ml, alpha-fetoprotein (AFP)>2000ng / ml, HBV drug-resistant mutation: genotype C detected M204I / L type, because the patient's AFP was significantly elevated, in order to rule out liver malignant lesions, liver magnetic resonance plain scan was given And after the dynamic enhancement of Ma Genweixian, it prompts: 1. Abnormal signal shadow in the right posterior lobe of the liver, considering degenerative nodules, further clinical diagnosis is r...

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Abstract

The invention discloses a novel mechanism for promoting human tumor generation and development. The core of the novel mechanism comprises that intracellular high ammonia metabolism can keep tumor cell warburg effects. Warburg effects are a metabolic basis of tumor cell generation, development, transfer and tolerance processes and thus after tumor cell ammonia reduction treatment, the tumor cell is short of continuous supply and keeping of ammonia so that cell apoptosis and necrocytosis or tumor cell induced redifferentiation is fast produced and reduction of an ammonia concentration in a tumor cell is a novel tumor treatment target spot. A drug for ammonia concentration reduction in the novel mechanism is arginine. The novel mechanism can be used for reducing an ammonia concentration of a liver cancer cell thereby realizing continuous supply and keeping of liver cancer cell deficient ammonia so that cell apoptosis and necrocytosis or liver cancer cell induced redifferentiation is fast realized.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to a new mechanism for promoting the occurrence and development of human tumors, specifically a new mechanism for maintaining the occurrence of human tumors by intracellular high ammonia metabolism. Background technique [0002] We know that all organisms have the ability to use energy, that is, metabolism. Cancer cells dramatically speed up their metabolic processes, causing the mutated cells to grow wildly. As far back as the early 20th century, scientists have discovered that cancer cells prefer to use glucose as an energy source, even though they have abundant other energy resources. This preference for using glucose as "fuel" is known as the Warburg effect, or glycolysis. The Warburg effect is the metabolic basis of cancer cell growth, development, metastasis and resistance to therapy. Cells use nutrients to generate energy in two ways: mitochondrial metabolism and glycolysis. Norm...

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Application Information

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IPC IPC(8): A61K31/198A61P35/00A61P1/16
CPCA61K31/198
Inventor 余祖江
Owner 余祖江
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