Novel mechanism for promoting human tumor generation and development

A mechanism and tumor technology, applied in the field of biomedicine, can solve the problems of low ATP quantity, high glucose uptake rate, high metabolite lactic acid content, etc.
CN105902528AInactive Publication Date: 2016-08-31余祖江
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
余祖江
Publication Date
2016-08-31
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a novel mechanism for promoting human tumor generation and development. The core of the novel mechanism comprises that intracellular high ammonia metabolism can keep tumor cell warburg effects. Warburg effects are a metabolic basis of tumor cell generation, development, transfer and tolerance processes and thus after tumor cell ammonia reduction treatment, the tumor cell is short of continuous supply and keeping of ammonia so that cell apoptosis and necrocytosis or tumor cell induced redifferentiation is fast produced and reduction of an ammonia concentration in a tumor cell is a novel tumor treatment target spot. A drug for ammonia concentration reduction in the novel mechanism is arginine. The novel mechanism can be used for reducing an ammonia concentration of a liver cancer cell thereby realizing continuous supply and keeping of liver cancer cell deficient ammonia so that cell apoptosis and necrocytosis or liver cancer cell induced redifferentiation is fast realized.
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Description

technical field

[0001] The invention belongs to the field of biomedicine, and relates to a new mechanism for promoting the occurrence and development of human tumors, specifically a new mechanism for maintaining the occurrence of human tumors by intracellular high ammonia metabolism. Background technique

[0002] We know that all organisms have the ability to use energy, that is, metabolism. Cancer cells dramatically speed up their metabolic processes, causing the mutated cells to grow wildly. As far back as the early 20th century, scientists have discovered that cancer cells prefer to use glucose as an energy source, even though they have abundant other energy resources. This preference for using glucose as "fuel" is known as the Warburg effect, or glycolysis. The Warburg effect is the metabolic basis of cancer cell growth, development, metastasis and resistance to therapy. Cells use nutrients to generate energy in two ways: mitochondrial metabolism and glycolysis. Norm...

Claims

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