Bamboo leaf flavone composite nanoparticles with whitening effect and preparation method thereof

A technology of composite nanoparticles and bamboo leaf flavonoids, which is applied in the field of daily chemicals, can solve the problems of limiting the application of whitening preparations, low solubility of bamboo leaf flavonoids, and difficult skin absorption, etc., and achieves excellent tyrosinase activity inhibition, particle size Uniform and controllable, strong whitening effect

Active Publication Date: 2019-01-08
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, like other flavonoids, bamboo leaf flavonoids have problems such as low solubility, darker color, and difficulty in being absorbed by the skin, which limit their application in whitening preparations

Method used

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  • Bamboo leaf flavone composite nanoparticles with whitening effect and preparation method thereof
  • Bamboo leaf flavone composite nanoparticles with whitening effect and preparation method thereof
  • Bamboo leaf flavone composite nanoparticles with whitening effect and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Embodiment 1, a kind of bamboo leaf flavone composite nanoparticle preparation method with whitening effect:

[0051] (1) Dissolve 4 mg of bamboo leaf flavonoids in 2 mL of distilled water, heat and stir to dissolve;

[0052] (2) Add 24 mg of bamboo leaf polysaccharide to the solution obtained in step (1) and stir to dissolve to obtain bamboo leaf flavonoids- bamboo leaf polysaccharide solution;

[0053] (3) Dissolve 2 mg of ε-polylysine in 1 mL of distilled water;

[0054] (4) Drop the solution obtained in step (3) into the bamboo leaf flavone-bamboo polysaccharide solution for 1 minute (ie, at a flow rate of about 200mL / h) under the condition of magnetic stirring at a rotational speed of 100-300r / min;

[0055] (5) Continue to stir at a low speed (100-300r / min) for 30 minutes, and the obtained opalescent suspension is bamboo leaf flavonoid composite nanoparticle solution (I) with whitening effect.

Embodiment 2

[0056] Embodiment 2, a kind of bamboo leaf flavonoid composite nanoparticle preparation method with whitening effect:

[0057] (1) Dissolve 4 mg of bamboo leaf flavonoids in 2 mL of distilled water, heat and stir to dissolve;

[0058] (2) Add 36 mg of bamboo leaf polysaccharide to the solution obtained in step (1) and stir to dissolve to obtain bamboo leaf flavonoids- bamboo leaf polysaccharide solution;

[0059] (3) 2 mg of ε-polylysine was dissolved in 2 mL of distilled water;

[0060] (4) Drop the solution obtained in step (3) into the bamboo leaf flavone-bamboo polysaccharide solution for 1 minute (ie, at a flow rate of about 300mL / h) under the condition of magnetic stirring at a rotational speed of 100-300r / min;

[0061] (5) Continue to stir at a low speed for 30 minutes, and the obtained opalescent suspension is bamboo leaf flavonoid composite nanoparticle solution (II) with whitening effect.

Embodiment 3

[0062] Embodiment 3, a kind of preparation method of composite nanoparticle of bamboo leaf flavonoids with whitening effect:

[0063] (1) Dissolve 4mg of bamboo leaf flavonoids in 16mL of distilled water, heat and stir to dissolve;

[0064] (2) Add 50 mg of coriander root polysaccharide into the solution obtained in step (1) and stir to dissolve to obtain bamboo leaf flavonoid-coriander root polysaccharide solution;

[0065] (3) 10 mg of ε-polylysine was dissolved in 4 mL of distilled water;

[0066] (4) Drop the solution obtained in step (3) into the bamboo leaf flavonoid-corydalone polysaccharide solution for 6 minutes (that is, at a flow rate of about 200mL / h) under the condition of magnetic stirring at a rotational speed of 100-300r / min;

[0067] (5) Continue stirring at a low speed for 30 minutes, and the obtained opalescent suspension is bamboo leaf flavonoid composite nanoparticle solution (III) with whitening effect.

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Abstract

The invention discloses bamboo leaf flavonoid composite nano-particles. The bamboo leaf flavonoid composite nano-particles are prepared from the following three components in percentage by weight: 6 to 13.5 percent of bamboo leaf flavonoids, 70 to 86 percent of acidic polysaccharides and 0.5 to 24 percent of a cationic cross linking agent. The bamboo leaf flavonoids are extracts of bamboo leaves, and the content of the total flavonoids in the bamboo leaf flavonoids is 20 to 80 percent; the acidic polysaccharides are the polysaccharides which are plant derived and contain acidic groups; the cationic cross linking agent is an acceptable cationic cross linking agent in the field of cosmetics. The invention also discloses a preparation method for the bamboo leaf flavonoid composite nano-particles. The bamboo leaf flavonoid composite nano-particles have a skin whitening effect.

Description

technical field [0001] The invention belongs to the technical field of daily chemicals and relates to a nano particle, in particular to a composite nano particle of bamboo leaf flavonoids with whitening effect and a preparation method thereof, which are applied in the daily chemical industry. Background technique [0002] In the cosmetics market, whitening products have always received great attention and popularity. Through the use of whitening skin care products, Orientals want to obtain fair and smooth skin, while European and American consumers hope to reduce and eliminate pigmentation such as age spots and chloasma. Normal human skin color mainly depends on the content of melanin in the skin. The formation of melanin occurs in melanocytes. Under the catalysis of tyrosinase, etc., tyrosine is gradually oxidized into dopa and dopaquinone, and finally transformed into For the enzymatic reaction of melanin. Melanocytes transfer melanin to the basal layer of the epidermis,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9794A61K8/88A61K8/02A61K8/20A61K8/73A61Q19/02
CPCA61K8/0241A61K8/20A61K8/73A61K8/733A61K8/88A61K8/97A61K2800/413A61K2800/72A61K2800/782A61Q19/02
Inventor 张英王楠
Owner ZHEJIANG UNIV
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