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Traditional Chinese medicinal composition and application thereof in preparation of blood lead reducing medicines

A composition and technology of traditional Chinese medicine, applied in the application field of preparation of blood lead-lowering drugs, can solve problems such as lack of many related records, achieve strong lead-driving effect, reduce blood lead and brain lead levels, and have good promotion and application prospects Effect

Active Publication Date: 2016-09-14
ZHEJIANG PROVINCIAL HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Hyperleademia and lead poisoning are diseases discovered in modern times, and there are not many related records in traditional medicine

Method used

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  • Traditional Chinese medicinal composition and application thereof in preparation of blood lead reducing medicines
  • Traditional Chinese medicinal composition and application thereof in preparation of blood lead reducing medicines
  • Traditional Chinese medicinal composition and application thereof in preparation of blood lead reducing medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 Blood Lead Reducing Drug Granules

[0020] The formula of the traditional Chinese medicine composition of the present invention: 166.7 grams of Yizhiren, 400 grams of Zhiwu, 800 grams of calcined oysters, 166.7 grams of Hangbai Shao, 133.3 grams of Zhiyuanzhi, 133.3 grams of Shichangpu, 133.3 grams of Schisandra chinensis, and 133.3 grams of raw licorice.

[0021] The preparation method of the traditional Chinese medicine composition: according to the formula amount, add water to the calcined oyster and then decoct twice, the first time 2.0h, the second time 1.5h, combine the second decoction and filter, and the filtrate (namely the calcined oyster filtrate) is set aside . The remaining medicine was submerged in water and decocted three times, each time for 1.0h, and the three filtrates were combined (namely the mixed filtrate), and set aside. Combine calcined oyster filtrate and mixed filtrate, concentrate at 60°C with a single-effect external circulation co...

Embodiment 2

[0023] Embodiment 2: the research (attaching 100 cases of clinical curative effect observations) of reducing blood lead drug to children's lead poisoning

[0024] 1. Objects and methods

[0025] 1.1 Object

[0026] The case came from the pediatric outpatient clinic of our hospital. According to the diagnostic criteria for lead poisoning in children established by the CDC (National Center for Disease Control and Prevention) in 1991, any blood lead level exceeding or equal to 10 μg / dL, regardless of whether there are corresponding clinical symptoms, signs and other blood Biochemical changes can be diagnosed as lead poisoning in children. The determination of blood lead was determined according to the method specified in GB5009.112, and was uniformly determined by the Zhejiang Provincial Trace Element Testing Center Laboratory. A total of 180 children with blood lead concentration ≥ 10 μg / dL were selected, aged 4-12 years, according to the clinical syndrome of traditional Chine...

Embodiment 3

[0045] Example 3: Effect of traditional Chinese medicine composition on blood lead and hippocampal nitric oxide synthase in low-level lead-exposed offspring rats

[0046] 1 Materials and methods

[0047] 1.1 Establishment of animal models

[0048] Select 50 healthy, newly weaned Wistar rat offspring, weighing 80-100g, provided by the Experimental Animal Center of Zhejiang University of Traditional Chinese Medicine, and randomly divide them into 5 groups with 10 rats in each group, which are model group, EDTA control group, and traditional Chinese medicine Composition low-dose group, Chinese medicine composition middle-dose group and Chinese medicine composition high-dose group. Each group was fed with deionized water containing 0.2% lead acetate for modeling (research at home and abroad showed that rats drinking water containing 0.2% lead (2000mg / L) were considered to be low-level lead exposure). Each group was fed with a common formula of conventional basal feed for 15 days...

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Abstract

The invention discloses a traditional Chinese medicinal composition and an application thereof in the preparation of blood lead reducing medicines. The traditional Chinese medicinal composition is prepared from, by mass, 130-260 parts of Seleno-k-carrageenan, 330-460 parts of Radix Polygonum Multiflorum Preparata, 670-930 parts of calcined oyster shell, 130-240 parts of white peony root from Hangzhou, 100-160 parts of processed Radix Polygalae, 100-240 parts of Acorus gramineus, 100-160 parts of Chinese magnoliavine, and 100-160 parts of raw licorice root. The traditional Chinese medicinal composition reduces the blood lead and brain lead level of lead poisoning rats and newborn mice, reduces the electric shock frequency, improves the memory keeping rate, mitigates lead nerve poisons, improves the NOS activity of hippocampus, effectively reduces the blood lead level of poisoned children, improves the attention deficit hyperactivity disorder of the children, and has no obvious toxic or side effects, so the composition has good promotion and application prospect.

Description

(1) Technical field [0001] The invention relates to a traditional Chinese medicine composition and its application in the preparation of medicines for reducing blood lead. (2) Background technology [0002] Lead is an environmental pollutant. The ideal level in the human body is zero. It is absorbed into the human body through the digestive tract and respiratory tract, which can cause damage to multiple organs and systems, among which the damage to the nervous system is particularly serious. The neurotoxicity of lead, the damage to the developing nervous system of fetuses and infants is mainly manifested in the central nervous system, which can cause learning and memory decline, hearing impairment and ataxia, etc. The impact has certain persistence and irreversibility , can persist into adulthood even after cessation of lead exposure. Experiments also show that the content of lead in tissues has a significant correlation with learning and memory. The content of lead in bloo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9062A61P39/02A61K35/618
CPCA61K35/618A61K36/484A61K36/57A61K36/65A61K36/69A61K36/704A61K36/71A61K36/79A61K36/888A61K36/9062A61K2236/331A61K2236/53A61K2300/00
Inventor 宣桂琪王晓鸣宣晓波
Owner ZHEJIANG PROVINCIAL HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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