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Traditional Chinese medicine preparation for preventing and treating alzheimer disease and preparation method thereof

A technology of Alzheimer's disease and traditional Chinese medicine, applied in the field of medicine, can solve the problem of dosage increase, achieve huge application prospects, definite curative effect, and improve the effect of synaptic plasticity

Active Publication Date: 2016-09-21
深圳市锦泰医药科技合伙企业有限合伙 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, AD requires long-term medication, and cholinesterase inhibitors often need to be increased to achieve the desired effect after long-term medication

Method used

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  • Traditional Chinese medicine preparation for preventing and treating alzheimer disease and preparation method thereof
  • Traditional Chinese medicine preparation for preventing and treating alzheimer disease and preparation method thereof
  • Traditional Chinese medicine preparation for preventing and treating alzheimer disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Raw materials: Coptidis 5g, Evodia 2g, Uncaria 8g, American ginseng 3g, Rhodiola rosea 5g, pokeweed flower 4g, bezoar 0.2g, borneol 0.1g. Each medicinal material is pulverized into fine powder and packed into capsules (it should be understood that this embodiment can also be made into pills, tablets, dripping pills, etc. by the methods commonly used in pharmacy).

Embodiment 2

[0026] Raw materials: Coptidis 5g, Evodia 2g, Uncaria 8g, American ginseng 3g, Rhodiola rosea 5g, pokeweed flower 4g, bezoar 0.2g, borneol 0.1g. Crush American ginseng, bezoar and borneol into fine powder for later use. Add 8-16 times (weight) of water to Coptidis, Evodia, Uncaria, Rhodiola, Pokeweed, etc., decoct for 1 hour, filter, and set aside the filtrate; add 8-16 times (weight) water to the filter residue, decoct for 1 hour hours, filter, discard the filter residue, combine the previous filtrate, concentrate, and dry to make dry extract powder; mix the dry extract powder with American ginseng, bezoar and borneol fine powder, granulate or pellet, and pack into capsules ( It should be understood that this embodiment can also be made into pills, tablets, etc. by the methods commonly used in pharmacy).

Embodiment 3

[0028] Raw materials: Coptidis 5g, Evodia 2g, Uncaria 8g, American ginseng 3g, Rhodiola rosea 5g, pokeweed flower 4g, bezoar 0.2g, borneol 0.1g. Add 8-16 times (weight) of water to American ginseng, coptis, evodia, uncaria, rhodiola, pokeweed, etc., decoct for 1 hour, filter, and set aside the filtrate; add 8-16 times (weight) of water to the filter residue, Boil for 1 hour, filter, discard the filter residue, combine the previous filtrate, concentrate; add bezoar and borneol, then add appropriate additives and purified water to adjust to the specified concentration, and make a liquid preparation such as a mixture.

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Abstract

The invention provides a traditional Chinese medicine composition for preventing and treating alzheimer disease. The composition is prepared from the following components in parts by weight: 30-70 parts of coptis chinensis, 5-40 parts of fructus evodiae, 60-100 parts of uncaria rhynchophylla, 10-50 parts of American ginseng, 30-70 parts of rhodiola rosea, 20-60 parts of flowers of phytolacca acinosa, 0.5-5 parts of calculus bovis and 0.05-3 parts of borneol. The invention further provides a traditional Chinese medicine preparation prepared from the traditional Chinese medicine composition and a preparation method thereof. The traditional Chinese medicine composition can be used for remarkably improving the learning and memory capability and cognition impairment of a spontaneous AD model mouse and other multiple AD pathological models, has an exact curative effect in treatment of AD due to pathogenic fire derived from stagnation of liver, and has a great application prospect.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a traditional Chinese medicine composition for preventing and treating Alzheimer's disease, a traditional Chinese medicine preparation and a preparation method thereof. Background technique [0002] China has entered an aging population society. Statistics show that by the end of 2014, China's elderly population over the age of 60 had reached 212 million, accounting for 15.5% of the total population. my country has become a large aging country in the world. According to reports, 10% of the elderly over the age of 65 in the world suffer from senile dementia, and the prevalence rate over the age of 80 is as high as 20%. Alzheimer's disease (Alzheimer's disease, referred to as AD) has become the fourth killer of human beings after heart disease, cancer and stroke. Epidemiological surveys show that there are at least 6 million senile dementia patients in my country, and the annua...

Claims

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Application Information

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IPC IPC(8): A61K36/754A61P25/28A61K35/413A61K31/045
Inventor 曾永长吴正治梁少瑜
Owner 深圳市锦泰医药科技合伙企业有限合伙
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