Unlock instant, AI-driven research and patent intelligence for your innovation.

Herba artemisiae scopariae clathrate compound detection method

A detection method and technology for inclusion compounds, which can be applied to measurement devices, instruments, scientific instruments, etc., can solve the problems of difficulty in extracting volatile oil, difficulty in operation of inclusion process, and volatilization loss.

Active Publication Date: 2016-10-05
JIUZHITANG +1
View PDF6 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Yinchen is a member of common Chinese medicine prescriptions, and the preparation of its inclusion compound is a step in the preparation of Chinese medicine preparations. For example, Yiganning Granules are recorded in Part 1 of the "Chinese Pharmacopoeia" 2010 Edition. However, in the actual production process of the preparation, the yield of the volatile oil of the capillary is very low, which makes it difficult to operate the subsequent inclusion process, and it is difficult to meet the actual production requirements of the drug, which affects the quality of the drug
The inventor analyzes that its reason mainly contains: (1) adopt steam distillation method to extract process temperature higher, and be open system, cause volatilization loss; The volatile oil is soluble in water and cannot be separated in time; (3) the relative density of the volatile oil of Capillary chinensis is 0.969, which is relatively close to water, and the volatile oil forms small emulsion droplets in water, which is not easy to separate; The report is only 3.0*10 －4 ml / g), it is difficult to extract volatile oil in actual production
The inventors tackled these technical difficulties, and explored a new preparation method for capillary volatile oil inclusion compound, but there is no suitable method to detect capillary volatile oil inclusion compound in the prior art, which is not conducive to the production process. Quality Control

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Herba artemisiae scopariae clathrate compound detection method
  • Herba artemisiae scopariae clathrate compound detection method
  • Herba artemisiae scopariae clathrate compound detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0095] prescription

[0096]

[0097] method

[0098] For the above 13 flavors, decoct Astragalus with water twice, 2 hours each time, combine the decoction, filter, and concentrate the filtrate to a clear paste with a relative density of 1.25 (20°C);

[0099]The volatile oil (in the form of aromatic water) is extracted by straight-through distillation for 2 hours, and the aromatic water of the bacteria is collected; take 290g of β-cyclodextrin, add 5% ethanol to the total weight of the aromatic water, and stir in a water bath at 40°C-45°C Inclusion for 2 hours, refrigerated, and stand still for more than 12 hours; filter, wash with 29g ethanol for 3 times, dry at 40°C-45°C, crush through a 65-mesh sieve to obtain the inclusion compound of capillary volatile oil, and set aside;

[0100] Add the dregs and the rest of Codonopsis pilosula and other eleven flavors to decoct with water twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate to ...

Embodiment 2

[0110] prescription

[0111]

[0112] method

[0113] For the above 13 flavors, decoct Astragalus with water twice, 2 hours each time, combine the decoction, filter, and concentrate the filtrate to a clear paste with a relative density of 1.25 (20°C);

[0114] The volatile oil (in the form of aromatic water) is extracted by the straight-through distillation method, and the extraction time is 1.5 hours, and the aromatic water of the bacteria is collected; take 290g of β-cyclodextrin, add 2.5% ethanol to the total weight of the aromatic water, and stir in a water bath at 40°C-45°C Inclusion for 3 hours, refrigerated, and let stand for more than 12 hours; filter, wash twice with 58g of ethanol, dry at 35°C-40°C, crush through 80 mesh sieve to obtain capillary volatile oil inclusion compound, set aside;

[0115] Decoct the dregs and other eleven flavors such as Codonopsis pilosula twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate to a cl...

Embodiment 3

[0121] prescription

[0122]

[0123]

[0124] method

[0125] For the above 13 flavors, decoct Astragalus with water twice, 2 hours each time, combine the decoction, filter, and concentrate the filtrate to a clear paste with a relative density of 1.25 (20°C);

[0126] The volatile oil (in the form of aromatic water) is extracted by the straight-through distillation method of capillary, and the extraction time is 1 hour, and the aromatic water of the bacteria is collected; take 290g of β-cyclodextrin, add 10% ethanol to the total weight of the aromatic water, and stir in a water bath at 40°C-45°C Inclusion compound for 2.5 hours, refrigerated, and stand still for more than 12 hours; filter, wash with 45g ethanol for 4 times, dry at 45°C-50°C, crush and pass through a 65-mesh sieve to obtain the clathrate of capillary volatile oil, which is ready for use;

[0127] Decoct the dregs and other eleven flavors such as Codonopsis pilosula twice, each time for 2 hours, combine ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a thin-layer identification method for herba artemisiae clathrate volatile oil. Compared with the prior art, the method is easy and convenient to operate, high in specificity and good in separation effect, quality of herba artemisiae clathrate volatile oil is controlled easily and reliably, and medicine quality is guaranteed.

Description

technical field [0001] The invention belongs to the technical field of detection of traditional Chinese medicine preparations, and in particular relates to a detection method of inclusion compounds. Background technique [0002] Yinchen is a member of common Chinese medicine prescriptions, and the preparation of its inclusion compound is a step in the preparation of Chinese medicine preparations. For example, Yiganning Granules are recorded in Part 1 of the "Chinese Pharmacopoeia" 2010 Edition. However, in the actual production process of the preparation, the yield of the volatile oil of the capillary is very low, which makes it difficult to operate the subsequent inclusion process, and it is difficult to meet the actual production requirements of the drug, which affects the quality of the drug. The inventor analyzes that its reason mainly contains: (1) adopt steam distillation method to extract process temperature higher, and be open system, cause volatilization loss; The ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90
Inventor 辛秀谷陟欣谢安戴向国黄胜张妮瑜袁莉
Owner JIUZHITANG