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A kind of preparation method of Shenzhiling preparation

A technology of ginseng and preparations, applied in the field of preparation of ginseng preparations, can solve the problems of low content of active ingredients, incomplete absorption, low bioavailability and the like

Active Publication Date: 2020-02-14
SHANDONG WOHUA PHARMACEUTICALS CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation method of Shenzhiling preparations in the prior art, the preparation process is to extract volatile oil from part of the medicinal materials, and carry out water extraction and alcohol precipitation of the crude products of some medicinal materials, which have low active ingredient content, large dosage, incomplete absorption, biological Inadequacies such as low utilization
With the continuous development of science and technology and the continuous improvement of the level of new drug research and development, the continuous application of new theories, new technologies, new processes, and new equipment, its traditional preparation process does not fully meet the requirements of modernization of traditional Chinese medicine.

Method used

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  • A kind of preparation method of Shenzhiling preparation

Examples

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Embodiment 1

[0033] Embodiment 1 prepares Shenzhiling oral liquid

[0034] The raw materials are as follows: Codonopsis 750g, Guizhi 500g, Paeoniae Alba 500g, Honey-roasted Glycyrrhiza 500g, Poria 750g, Dried Ginger 500g, Polygala 450g, Calamus shichangpu 500g, Keel 1500g, Oyster 1500g.

[0035] The preparation method steps are as follows:

[0036] (1) Take cassia twigs and dried ginger, pulverize them, add water 5 times the weight of the medicinal materials, heat and reflux for 2 hours to distill, collect the initial distillate, and redistill for 1 hour; extract volatile oil; filter the distillate, and use the medicinal residue for later use;

[0037] (2) Codonopsis pilosula, Radix Paeoniae Alba, Radix Glycyrrhizae, Poria cocos, polygala, Shichangpu pulverize, merge with the dregs of traditional Chinese medicine in step (1), add water with a pH value of 2.0 (add hydrochloric acid to the water to adjust to a pH value of 2.0), add water The amount is 3 times of the weight of the medicinal ...

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Abstract

The invention discloses a preparation method of Shenzhiling preparation, which comprises the following steps: (1) taking cassia twig and dried ginger, adding water to heat and reflux distillation, and extracting volatile oil; (2) taking codonopsis pilosula, white peony root, licorice, poria and calamus calamus, crushed, combined with the dregs of traditional Chinese medicine in step (1), adding water with a pH value of 1.5 to 2.5, heating and extracting; (3) taking the keel and oysters, merging with the dregs obtained in step (2) 6.5 to 7.0 water, heating and extracting; (4) adding water with a pH value of 7.8 to 8.5 to the dregs obtained in step (3), heating and extracting; (5) combining the filtrate obtained in steps (2), (3) and (4), Concentrate to a clear paste, add volatile oil, mix well, add pharmaceutically acceptable carriers or auxiliary materials, and prepare pharmaceutical preparations. The Shenzhiling preparation prepared by the method of the invention has the advantages of high active ingredient content, high bioavailability, and is more suitable for human body absorption.

Description

technical field [0001] The invention relates to a preparation method of a Shenzhiling preparation, which belongs to the technical field of traditional Chinese medicine preparations. Background technique [0002] Alzheimer's disease (Alzheimer's disease) is an acquired intellectual impairment syndrome with cognitive impairment as the core symptom. The degree of intellectual impairment is enough to interfere with social or occupational functions. It is a chronic progressive disease. The scope involves various advanced neural functions such as memory, behavior, personality, judgment, attention, visuospatial skills, language, and logical reasoning. According to statistics, dementia has become the fourth largest killer after cardiovascular disease, cancer and stroke, seriously threatening the health and quality of life of the elderly. It is predicted that by 2030, the number of people suffering from Alzheimer's disease in the world will reach 60 million, and there will be 12 mil...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61P25/28A61K35/02A61K35/618
CPCA61K35/02A61K35/618A61K36/076A61K36/344A61K36/484A61K36/54A61K36/65A61K36/69A61K36/71A61K36/888A61K36/9068A61K2236/331A61K2236/39A61K2300/00
Inventor 周万辉曾英姿王冬梅于洪亮赵磊程世娟
Owner SHANDONG WOHUA PHARMACEUTICALS CO LTD
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