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Crude medicine powder intermittent sterilization method

An intermittent, medicinal material technology, applied in pharmaceutical formulations, powder delivery, plant raw materials, etc., can solve the problems of specific implementation methods and methods of sterilization of Chinese herbal decoction pieces that are not mentioned, and ensure the safety of medication, efficacy, and consumption. Low energy and simple preparation method

Inactive Publication Date: 2016-10-12
湖南盟合投资管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the specific implementation means and methods of the sterilization of Chinese herbal decoction pieces are not mentioned in the article, and the creative work of those skilled in the art is still needed to realize

Method used

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  • Crude medicine powder intermittent sterilization method
  • Crude medicine powder intermittent sterilization method
  • Crude medicine powder intermittent sterilization method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Coix Seed Broken Wall Decoction Pieces

[0028] Medicinal material processing: the coix seed medicinal material is sorted, cleaned, dried, sliced, and coarsely crushed to about 100 mesh;

[0029] Kill bacteria propagules: Coix seed coarse powder is placed in a constant temperature and humidity box with a thickness of about 10mm, set the temperature at 65°C (the actual temperature is 60-70°C), and keep it dry and sterilized for 8 hours;

[0030] Dormant body growth: the treated coarse powder of medicinal materials is maintained at a temperature of 25°C and a relative humidity of 75% for 12 hours; then the temperature of the constant temperature and humidity box is adjusted to 35°C and a relative humidity of 88% is maintained for 24 hours;

[0031] Sterilize the propagule again: set the temperature to 75°C (the actual temperature is 70-80°C), keep it dry and sterilized for 4 hours.

[0032] Routine detection of microorganisms in coarse powder of medicinal materials must ...

Embodiment 2

[0035] Cinnamon Broken Drink Pieces

[0036] Medicinal material processing: the cinnamon medicinal material is sorted, cleaned, dried, sliced, and coarsely crushed to about 100 mesh;

[0037] Kill bacteria propagules: put cinnamon coarse powder in a constant temperature and humidity box, place the thickness of each plate is about 25mm, set the temperature at 55°C (the actual temperature is 50-60°C), keep it dry and sterilized for 0.5h;

[0038] Dormant body growth: adjust the temperature to 30°C and maintain a relative humidity of 80% for 8 hours, adjust the temperature to 37°C and maintain a relative humidity of 92% for 15 hours;

[0039] Kill the vegetative growth again: set the temperature to 55°C (the actual temperature is 50-60°C), keep it dry and sterilized for 8 hours;

[0040] Repeat the dormant body growth-kill the vegetative body again step 2 times, routinely detect the microbial situation in the coarse powder of medicinal materials, and routinely detect the microbi...

Embodiment 3

[0044] Coix Seed Broken Wall Decoction Pieces

[0045] Medicinal material processing: the coix seed medicinal material is sorted, cleaned, dried, sliced, and coarsely crushed to about 100 mesh;

[0046] Kill bacteria propagules: Coix seed coarse powder is placed in a constant temperature and humidity box with a thickness of about 5mm, set the temperature at 70°C (the actual temperature is 65-75°C), and keep it dry and sterilized for 4 hours;

[0047] Dormant body growth: the treated coarse powder of medicinal materials is maintained at a temperature of 20°C and a relative humidity of 70% for 15 hours; then the temperature of the constant temperature and humidity box is adjusted to 33°C and a relative humidity of 83% is maintained for 8 hours;

[0048] Kill the vegetative growth again: set the temperature to 65°C (the actual temperature is 60-70°C), keep it dry and sterilized for 6 hours;

[0049] Repeat the step of dormant body growth-killing the vegetative body again once, a...

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Abstract

The invention provides a crude medicine powder intermittent sterilization method. The method comprises pretreating traditional Chinese medicines through a conventional method to obtain crude medicine powder, carrying out bacterial reproductive body killing, hypopus growth and reproductive body re-killing to obtain crude medicine powder satisfying microbial limit requirements, and carrying out wall-breaking crushing, soft material preparation, granulation, drying and coating to obtain a wall-broken decoction piece. The method hardly influences medicinal material effects. The product satisfies microbe limit requirements and guarantees drug use safety and effectiveness.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine treatment, in particular to an intermittent sterilization method for coarse powder of medicinal materials. Background technique [0002] In the process of preparing traditional Chinese medicine, it is a technical problem to sterilize Chinese medicinal materials, medicinal powder and decoction pieces. The traditional sterilization techniques are mainly dry heat sterilization, moist heat sterilization, radiation sterilization and oxidative gas (such as ozone, ethylene oxide) sterilization. Dry heat sterilization may lead to a decrease in the content of medicinal materials and affect the efficacy of the medicine; damp heat Sterilization may lead to the cooking of medicinal materials, which also leads to a decrease in content and even changes in medicinal properties; oxidative gas sterilization may cause oxidative denaturation of medicinal materials and affect medicinal efficacy; ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L2/04A61K9/14A61K36/8994A61K36/54
CPCA61L2/0023A61K9/14A61K36/54A61K36/8994A61L2202/21
Inventor 杨记宗朱瑞清张小春关建雄罗铭中
Owner 湖南盟合投资管理有限公司
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