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Pharmaceutical composition of digoxin and application thereof in biomedicine

A technology of digoxin and its composition, which is applied in the field of pharmaceutical composition and its application in biomedicine, can solve the unseen problems related to cholecystitis and cholelithiasis, etc., and achieve the effect of improving the therapeutic effect

Inactive Publication Date: 2016-10-12
胡逸穹
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between digoxin and its pharmaceutical composition and cholecystitis and cholelithiasis

Method used

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  • Pharmaceutical composition of digoxin and application thereof in biomedicine
  • Pharmaceutical composition of digoxin and application thereof in biomedicine
  • Pharmaceutical composition of digoxin and application thereof in biomedicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0019] Separation method: (a) Grind Lily's grass (2kg), extract with 70% ethanol under hot reflux (15L×3 times), combine the extracts, concentrate until no alcohol smell (3L), and then use petroleum ether (3L×3 times), ethyl acetate (3L × 3 times) and water-saturated n-butanol (3L × 3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) step ( a) Use D101 type macroporous resin to remove impurities from the ethyl acetate extract in the medium, first elute with 20% ethanol for 9 column volumes, then use 65% ethanol for 10 column volumes, collect 65% eluate, and depressurize Concentrate to get 65% ethanol elution concentrate; (c) in step (b), 65% ethanol elution concentrate is separated with normal phase silica gel, and the volume ratio is 65:1 (9 column volumes), 35:1 ( 10 column volumes), 15:1 (8 column volumes) and 7:1 (8 column...

Embodiment 2

[0023] Embodiment 2: pharmacological action

[0024] In this example, the cholecystitis and cholelithiasis rabbit model was prepared by ligation of common bile duct incompleteness and Escherichia coli injection into the gallbladder, and the anti-cholecystitis and cholelithiasis of drugs were observed in terms of reducing the content of TNF-α and β-EP in local tissues and reducing the viscosity of bile. symptomatic effect.

[0025] 1. Materials and methods

[0026] 1.1 Animals

[0027] Select healthy rabbits aged 3-4 months, weighing 1.3kg-1.9kg, provided and raised by the Zoology Department of Hunan Medical University.

[0028] 1.2 Reagents and samples

[0029] Digoxin was purchased from China Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. The TNF radioimmunoassay kit was provided by Beijing East Asia Institute of Biotechnology, and the EP radioimmunoassay kit was provided b...

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Abstract

The invention discloses a pharmaceutical composition of digoxin and application thereof in biomedicine. The pharmaceutical composition of digoxin contains digoxin and a novel-structure natural product compound (I). The digoxin and compound (I) have the effects of treating cholecystitis and cholelithiasis when being independently used. The combination of the digoxin and compound (I) further enhances the treatment effects on cholecystitis and cholelithiasis, and can be developed into drugs for treating the cholecystitis and cholelithiasis. Compared with the prior art, the pharmaceutical composition has outstanding substantial characteristics and marked progress.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of digoxin, in particular to a medicinal composition of digoxin and its application in biomedicine. Background technique [0002] Digoxin is used for various acute and chronic cardiac insufficiency, as well as supraventricular tachycardia, atrial fibrillation and flutter. It is usually taken by mouth or given intravenously in patients with severe heart failure. [0003] So far, there is no report on the correlation between digoxin and its pharmaceutical composition and cholecystitis and cholelithiasis. Contents of the invention [0004] The object of the present invention is to provide a digoxin pharmaceutical composition, which contains digoxin and a natural product with a novel structure, and digoxin and the natural product can synergistically treat cholecystitis and cholelithiasis. [0005] Above-mentioned purpose of the present invention is achieved by following ...

Claims

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Application Information

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IPC IPC(8): C07D471/20A61K31/7048A61K31/439A61P1/16
CPCC07D471/20A61K31/439A61K31/7048A61K36/53A61K2300/00
Inventor 胡逸穹
Owner 胡逸穹
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