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Preparation method of dual-response hydrogel with acid sensitive groups and base sensitive groups

A dual-response, acid-base sensitive technology, used in the preparation of polyurethane hydrogels to improve mechanical properties and expand the scope of application

Active Publication Date: 2016-10-12
HUNAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are still some defects in the temperature- and pH-responsive hydrogels.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Add 100 kilograms of polyethylene glycol (the number-average molecular mass is 10000), 3.6 kilograms of toluene diisocyanate, and 150 kilograms of dimethylformamide into a 500 L reaction kettle with a stirrer, a thermometer and a reflux condenser. The reaction was carried out at 80° C. for 3 hours. Then 1.5 kg of 2,2-dimethylolbutyric acid, 1.8 kg of toluene diisocyanate, and 45 kg of dimethylformamide were added, the temperature was controlled at 80°C, and the reaction was carried out for 3 hours to obtain prepolymer I, which was set aside. Add 100 kilograms of polyethylene glycol (the number-average molecular mass is 10000), 3.6 kilograms of toluene diisocyanate, and 150 kilograms of dimethylformamide into another 500 L reactor with agitator, thermometer and reflux condenser, React at a temperature of 80° C. for 3 hours. Then add 1.4 kg of N-ethyldiethanolamine, 1.8 kg of toluene diisocyanate, and 45 kg of dimethylformamide, control the temperature at 80°C, and react...

Embodiment 2

[0032] Add 100 kg of polyethylene glycol (the number-average molecular mass is 10000), 5.2 kg of diphenylmethane diisocyanate, and 150 kg of dimethylacetamide into a 500L reaction kettle with a stirrer, a thermometer and a reflux condenser , reacted at a temperature of 82°C for 3 hours. Then add 3.0 kg of 2,2-dimethylolbutyric acid, 7.8 kg of diphenylmethane diisocyanate, and 50 kg of dimethylacetamide, control the temperature at 82°C, and react for 3 hours to obtain prepolymer I, which is set aside. Add 100 kg of polyethylene glycol (the number-average molecular mass is 10000), 5.2 kg of diphenylmethane diisocyanate, and 150 kg of dimethylacetamide into another 500 L reaction with a stirrer, thermometer and reflux condenser. In the kettle, react at a temperature of 82°C for 3 hours. Then add 2.8 kg of N-ethyldiethanolamine, 7.8 kg of diphenylmethane diisocyanate, and 50 kg of dimethylacetamide, control the temperature at 82°C, and react for 3 hours to obtain prepolymer II, w...

Embodiment 3

[0035] Add 100 kg of polyethylene glycol (the number-average molecular mass is 10000), 5.2 kg of diphenylmethane diisocyanate, and 150 kg of dimethyl sulfoxide into a 500L reaction kettle with a stirrer, a thermometer and a reflux condenser , reacted at a temperature of 85° C. for 3 hours. Then 1.5 kg of 2,2-dimethylolbutyric acid, 2.6 kg of diphenylmethane diisocyanate, and 45 kg of dimethyl sulfoxide were added, the temperature was controlled at 85°C, and the reaction was carried out for 3 hours to obtain prepolymer I, which was set aside. Add 100 kg of polyethylene glycol (the number-average molecular mass is 10000), 5.2 kg of diphenylmethane diisocyanate, and 150 kg of dimethyl sulfoxide into another 500 L reaction with a stirrer, thermometer and reflux condenser In the kettle, react at a temperature of 85°C for 3 hours. Then add 1.4 kg of N-ethyldiethanolamine, 2.6 kg of diphenylmethane diisocyanate, and 45 kg of dimethyl sulfoxide, control the temperature at 85°C, and r...

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Abstract

The invention discloses a preparation method of dual response hydrogel with acid sensitive groups and base sensitive groups. The method mainly comprises the steps that 1, polyethylene glycol, aliphatic diisocyanate and a solvent are subjected to a reaction in a reaction kettle, and a polyurethane prepolymer is obtained; 2, aliphatic diisocyanate, a chain extender with acid groups and a solvent are added into the reaction kettle for a reaction continuously, and a prepolymer I is obtained; in another reaction kettle, the reactions in step 1 and step 2 are repeated, the chain extender with the acid groups is changed into a chain extender with basic groups, and a prepolymer II is obtained; the prepolymer I and the prepolymer II are poured into the same reaction kettle, a hydroxyl containing cross-linking agent and a solvent are added for a reaction continuously, and a polyurethane solution is obtained; the polyurethane solution is put in a mold, dried in vacuum and soaked in a basic solution, an aziridine cross-linking agent is added for a reaction, and polyurethane hydrogel is obtained; the polyurethane hydrogel is soaked in deionized water and then freeze-dried, and the dual-response hydrogel is obtained.

Description

technical field [0001] The invention belongs to the technical field of production of a dual-response hydrogel, in particular to a method for preparing a polyurethane hydrogel having both acidic and alkaline pH-sensitive functional groups and dual-response characteristics to temperature and pH. Background technique [0002] Hydrogel is a network-like polymer material that can swell to an equilibrium volume in water but does not dissolve in water. According to the network bonding effect of hydrogel, it can be divided into physically cross-linked hydrogel and chemical cross-linked hydrogel. Physically cross-linked hydrogels form a cross-linked structure through intermolecular forces such as hydrogen bonds and electrostatic interactions; chemically cross-linked hydrogels are three-dimensional network polymers formed by cross-linking chemical bonds. Compared with physically cross-linked hydrogels, chemically cross-linked hydrogels are more stable in properties, so the research a...

Claims

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Application Information

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IPC IPC(8): C08G18/76C08G18/66C08G18/48C08G18/32C08G18/34C08G18/12C08L75/08C08K5/3412C08J3/075
CPCC08G18/12C08G18/4833C08G18/6688C08G18/6692C08G18/7614C08G18/7671C08G2210/00C08J3/075C08J2375/08C08K5/3412C08G18/324C08L75/08
Inventor 周虎余斌熊一帜周杰刘玄欧宝立王东东
Owner HUNAN UNIV OF SCI & TECH