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Method for preparing vinyl modified collagen membrane

A collagen film and collagen-based technology, which is applied in the field of preparation of vinyl-modified collagen films, can solve the problems of poor physical and mechanical properties of collagen films, complex preparation process of collagen films, etc., and achieve insufficient mechanical properties, Good economic benefits and social application value, the effect of improving mechanical properties

Inactive Publication Date: 2016-10-12
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a method for preparing a vinyl modified collagen film, which solves the problems of complex preparation process of the existing collagen film and poor physical and mechanical properties of the obtained collagen film

Method used

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  • Method for preparing vinyl modified collagen membrane
  • Method for preparing vinyl modified collagen membrane
  • Method for preparing vinyl modified collagen membrane

Examples

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Effect test

preparation example Construction

[0045]1) Preparation of vinyl collagen

[0046] The mass-volume ratio of collagen to phosphate buffer solution is 1:8-1:12 (g / mL), placed at 70°C±2°C and stirred for 0.5-1h. Among them, the pH of the phosphate buffer solution is 7.4, the main purpose is to fully dissolve the collagen and provide a relatively stable pH environment.

[0047] Methacrylic anhydride can react with primary amino-NH in lysine residues in collagen under heating conditions 2 A reaction takes place to form an amide bond, allowing the C=C in methacrylic anhydride to be incorporated into the collagen structure. During the reaction process, the phosphate buffer solution is mainly used to dissolve collagen and provide a relatively mild reaction environment. The amount of methacrylic anhydride is directly related to the number of C=C double bonds after grafting. If the amount of methacrylic anhydride is too small, the number of C=C double bonds grafted on the surface of collagen will be small, and will not...

Embodiment 1

[0056] Step 1: Weigh 5.0 g of collagen with a molecular mass of 181266, place it in 50 mL of phosphate buffer solution (pH 7.4), stir at 70°C for 0.5 h, and dissolve it fully to obtain a collagen solution; wait until the temperature drops to a stable 0.1mL of methacrylic anhydride was added dropwise to the collagen solution at a rate of 1mL / min in a water bath at 50°C, reacted for 2 hours, and the modified collagen solution was placed in a dialysis bag with a molecular weight of 3500D , using deionized water as the dialysate, dialyzed at 40°C for 24 hours, and obtained vinyl collagen solutions with different degrees of substitution;

[0057] Step 2, the concentration of choosing the photoinitiator in the collagen solution is 0.006%, and the photoinitiator Add to the vinyl collagen solution in step 1, ultrasonically shake at 40°C for 30 minutes, and mix well.

[0058] Step 3: Pour the evenly mixed collagen solution in step 2 into a polytetrafluoroethylene mold, place it in an...

Embodiment 2～6

[0060] Referring to Example 1, the difference from Example 1 is that in step 1, 0.3mL, 0.6mL, 1.2mL, 1.5mL and 1.8mL of methacrylic anhydride were sequentially mixed at a rate of 1mL / min under the condition of a water bath at a temperature of 50°C Add dropwise to the collagen solution.

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Abstract

The invention discloses a preparation method of a vinyl modified collagen film. Firstly, a vinyl collagen solution is prepared; in the presence of a certain concentration of photoinitiator, the vinyl collagen solution is placed under ultraviolet light, and after several hours Irradiation cross-links to form a film, which is insoluble in water and has high strength. The invention carries out vinyl modification on the collagen, and after the ultraviolet cross-linking is triggered by an initiator, the vinyl collagen has a dense network structure. The mechanical properties of the collagen film are improved, and the problem of insufficient mechanical properties of the collagen film is successfully solved. The process is simple, requires less raw materials, and has good economic benefits and social application value.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a preparation method of a vinyl modified collagen film. Background technique [0002] Collagen is rich in animal skin, cartilage, ligaments, tendons and other connective tissues, and there are extremely rich resources in China. Since most of the leather resources in our country are used in the form of tanning, the utilization rate is extremely low, and if the leather solid waste produced is not recycled, it will not only occupy the site, pollute the environment, but also damage the collagen resources. Great waste. In the past 20 years, with the development of molecular biology, people's understanding of the properties of collagen has become more and more in-depth, and its application fields have become more extensive. [0003] For collagen membranes, there are many domestic and foreign molding methods. Most of the research in China adopts the method of ca...

Claims

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Application Information

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IPC IPC(8): C08J5/18C08J3/28C08J3/24C08H1/00C08L89/00
CPCC08J5/18C08H1/00C08J3/24C08J2389/00
Inventor 徐娜王学川任龙芳马向东石叶叶强涛涛
Owner SHAANXI UNIV OF SCI & TECH
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