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Escitalopram oxalate oral disintegrating tablet and preparation method thereof

A technology for escitalopram oxalate and orally disintegrating tablets, applied in the field of medicine, can solve the problems of complex process, high requirements for coating technology and coating materials, delaying tablet disintegration, dissolution and absorption in vivo and the like

Inactive Publication Date: 2016-10-26
BEIJING VENTUREPHARM BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The original escitalopram oxalate tablet is film-coated to achieve taste-masking, light-proof, moisture-proof and anti-degradation purposes. It has high requirements for coating technology and coating materials, and the process is complicated. In addition, it will delay the tablet to a certain extent. Disintegration, dissolution and absorption in vivo

Method used

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  • Escitalopram oxalate oral disintegrating tablet and preparation method thereof
  • Escitalopram oxalate oral disintegrating tablet and preparation method thereof
  • Escitalopram oxalate oral disintegrating tablet and preparation method thereof

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Embodiment Construction

[0024] The following examples are used to further illustrate the present invention, and to further understand a kind of escitalopram oxalate orally disintegrating tablet and a preparation method thereof, but the present invention is not limited thereto.

[0025] The tablets compressed in the following examples and comparative examples, unless otherwise specified, were all compressed with the same type of tablet press, and the hardness was controlled within the range of 20-40N.

[0026] 1. Test

[0027] Test 1: Screening of disintegrants

[0028]

[0029] Preparation Process:

[0030] (1) Pass escitalopram oxalate through a 40-mesh sieve and set aside; add croscarmellose sodium / cross-linked povidone XL-10, respectively, and dry until the water content is lower than 3%, set aside.

[0031] (2) Add an appropriate amount of mannitol, microcrystalline cellulose and croscarmellose sodium / crospovidone XL-10 to make a soft material, granulate with a 30-mesh sieve, and dry to mois...

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Abstract

The invention discloses an oral disintegrating tablet containing escitalopram oxalate. The preparation is composed of a filling agent, especially referring to mannitol with good taste, microcrystalline cellulose having a certain disintegration function, an adhesive, a disintegrating agent, a flavoring agent and a lubricating agent. Silicon dioxide is added, so that the taste is effectively improved. When a patient takes the escitalopram oxalate oral disintegrating tablet disclosed by the invention, no water or less water is required and no chewing is required; when the drug is placed into the oral cavity, the drug is quickly dissolved or disintegrated after meeting saliva, and then the drug enters the digestive system following the autonomous or heteronomous swallowing action of the patient and then is absorbed and becomes effective. The oral disintegrating tablet is suitable for the acute and maintenance treatment for major depressive disorder of an adult and the acute treatment for generalized anxiety disorder of the adult. The invention also provides a preparation method which is simple in technique, is low in cost and belongs to the field of pharmaceutical technology.

Description

technical field [0001] The invention relates to an orally disintegrating tablet against severe depression and a preparation method thereof. The active ingredient is Escitalopram Oxalate. The preparation process of the preparation is simple and controllable, and it still has the same and stable The invention has the dissolution characteristics of the active ingredient, rapid onset and good compliance after oral administration, and belongs to the technical field of medicine. Background technique [0002] Depression is a common mental disorder, according to the World Health Organization. Worldwide, more than 350 million people of all ages suffer from depression. Depression can manifest as sadness, loss of enjoyment, listlessness, social withdrawal, and sometimes suicidal thoughts. According to professional organizations, the probability of suicide in patients with severe depression is 20 times higher than that of ordinary people. Depression differs from the usual mood swings...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/343A61K47/38A61K47/36A61K47/26A61K47/32A61P25/24
CPCA61K9/0056A61K9/2018A61K9/2027A61K9/2054A61K9/2059A61K31/343
Inventor 周梦婷马莉
Owner BEIJING VENTUREPHARM BIOTECH
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