Use of oridonin in the preparation of antidepressant drugs

A technology of oridonin and anti-depression, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., to achieve the effect of ensuring reliability

Active Publication Date: 2019-08-16
罗永强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the use of oridonin as the active ingredient in the prevention / treatment of depression has not been reported

Method used

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  • Use of oridonin in the preparation of antidepressant drugs
  • Use of oridonin in the preparation of antidepressant drugs
  • Use of oridonin in the preparation of antidepressant drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1. The effect of oridonin on the tail suspension experiment of animal depression model

[0045] Experimental animals:

[0046] CD1 mouse, male, weight 30-40 grams, provided by Beijing Weitong Lihua Laboratory Animal Technology Co., Ltd. License number: SCXK (京) 2012-0001. Animals are reared in separate cages, with a light-dark cycle of 12h / 12h, a room temperature of 20-22°C, free drinking water, and feed provided by the Experimental Animal Center of the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences.

[0047] Experimental drugs:

[0048] Rubescensine A was purchased from China Institute for Food and Drug Control, catalog number 111721-201403.

[0049] Imipramine hydrochloride (Imipramine hydrochloride) is a product of Sigma, the product number is I7379, and the batch number is O56K1380.

[0050] experiment equipment:

[0051] Crossbar; tape; Sumsung Intelli-200m digital video camera (South Korea's Samsung company); JUNSO multifunction timer.

...

Embodiment 2

[0068] Example 2. The effect of Rubescensine A on forced swimming experiment of animal depression model

[0069] Experimental animals:

[0070] CD1 mice, male, provided by Beijing Weitong Lihua Laboratory Animal Technology Co., Ltd. License number: SCXK (京) 2012-0001. The animals were raised in separate cages one week before the experiment, with a light-dark cycle of 12h / 12h, room temperature 20-22°C, free drinking water, and feed provided by the Experimental Animal Center of the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences.

[0071] Experimental drugs:

[0072] Rubescensine A was purchased from China Institute for Food and Drug Control, catalog number 111721-201403.

[0073] The positive control Imipramine hydrochloride (Imipramine hydrochloride) is a product of Sigma, the product number is I7379, the batch number is O56K1380.

[0074] laboratory apparatus:

[0075] Glass cylinder (height 40cm, diameter 14cm); mouse open box (length and width respectively...

Embodiment 3

[0085] Example 3. Open field experiment in mice

[0086] Since the shortening of the immobility time in the classical depression animal model may be caused by the central excitability of the drug, we conducted a field experiment in mice to test the central excitability of oridonin.

[0087] The experimental results showed that the total distance that the mice moved in the open box for 1 hour did not change significantly after the high-dose oridonin treatment (77.19+7.41m) and the control group (59.28±3.18m) (Anova, p>0.05, N=8-10), so the possibility of causing mania can be excluded. Therefore, Rubescensine A does have a significant antidepressant effect.

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Abstract

The invention relates to the technology of pharmacy, and particularly relates to application of oridonin in preparation of anti-depression medicines. The anti-depression medicinal ingredient of the anti-depression medicine provided by the invention is oridonin, and has an efficacy dosage 0.01-30mg oridonin per kilogram of the body weight; and an anti-depression effect can be generated in 60 minutes after the medicine is administrated. The medicine has the advantages of remarkable anti-depression effect, quick response, small dosage, small side effect and the like. In a mammal mouse tail suspension test, the oridonin has a more remarkable anti-depression effect than that of conventional anti-depression medicine imipramine, and is expected to become a novel quick and efficient anti-depression medicine without toxic or side effect.

Description

Technical field [0001] The invention relates to pharmaceutical technology, in particular to the use of oridonin in the preparation of antidepressant drugs. Background technique [0002] Depression, also known as depressive disorder, is characterized by significant and lasting depression. Clinically, it can be seen that depression is not commensurate with the situation. Emotional depression can range from gloomy to grief, low self-esteem, depression, and even pessimism, suicide attempts or behaviors. Some cases have obvious anxiety and motor agitation. In severe cases, hallucinations, delusions and other psychotic symptoms may occur. Each episode lasts at least two weeks or more and can last for several years. Most cases have a tendency to recur, most of which can be relieved each time, and some may have residual symptoms or become chronic. [0003] Drug therapy is the main treatment measure for depressive episodes above moderate. Traditional tricyclic and tetracyclic antidepres...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61P25/24
CPCA61K31/352
Inventor 杜若甫陈正华单丽萍
Owner 罗永强
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