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Radix clematidis active component as well as preparation method and application thereof

An effective component and a technology of Phytophthora, applied in the field of effective composition of Phytophthora and its preparation and application, can solve the problems of low efficacy and large content of impurities in extracted components, and achieve complete extraction, improved purity, and extraction rate. high effect

Inactive Publication Date: 2016-10-26
CHENGDU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] But at present, there are few reports about the research on the real effective part of Clematis clematis. In the prior art, medicinal ingredients are also extracted from Clematis clematis, but the extracted components have large impurity content and low drug efficacy, which cannot realize effective resource utilization. use

Method used

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  • Radix clematidis active component as well as preparation method and application thereof
  • Radix clematidis active component as well as preparation method and application thereof
  • Radix clematidis active component as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Extraction: get Clematis clematis and pulverize, add 8 times of amount 95% ethanol to reflux and extract for 90 minutes, filter to obtain the first extract and the first filter residue; add 8 times of amount 95% ethanol to reflux to extract 90 minutes in the first filter residue Minutes to obtain the second extract and the second filter residue, these two extractions mainly extract the alcohol-soluble substances in Clematis clematis; then add 8 times the amount of 50% ethanol in the second filter residue and reflux for 90 minutes to obtain the third extraction liquid and the third filter residue; 8 times the amount of 50% ethanol was added to the third filter residue and refluxed for 90 minutes to obtain the fourth extract and the fourth filter residue. These two extractions mainly extract the saponins large polar substances in Clematis clematis ; Merge the first extract, the second extract, the third extract and the fourth extract to obtain the total extract of Clem...

Embodiment 2

[0036] (1) Extraction: Get Clematis clematis and grind, add 6 times of amount of 90% ethanol to reflux and extract for 60 minutes, filter to obtain the first extract and the first filter residue; add 6 times of amount of 90% ethanol to reflux to extract 60 minutes Minutes to obtain the second extract and the second filter residue; add 6 times the amount of 55% ethanol to the second filter residue for reflux extraction for 60 minutes to obtain the third extract and the third filter residue; add 6 times the amount of 55% ethanol to the third filter residue Ethanol reflux extraction for 60 minutes to obtain the fourth extract and the fourth filter residue; combine the first extract, the second extract, the third extract and the fourth extract to obtain the total extract of Clematis clematis, and then concentrate under reduced pressure , to obtain the total extract of Clematis clematis;

[0037] (2) Extraction: add sherwood oil in Clematis clematis total extract extract according ...

Embodiment 3

[0040] (1) Extraction: get Clematis clematis and grind, add 7 times of amount of 93% ethanol for reflux extraction for 80 minutes, filter to obtain the first extract and the first filter residue; add 7 times of amount of 93% ethanol for reflux extraction of 80 minutes in the first filter residue Minutes to obtain the second extract and the second filter residue; add 7 times the amount of 40% ethanol to the second filter residue for reflux extraction for 70 minutes to obtain the third extract and the third filter residue; add 7 times the amount of 40% ethanol to the third filter residue Ethanol reflux extraction for 70 minutes to obtain the fourth extract and the fourth filter residue; combine the first extract, the second extract, the third extract and the fourth extract to obtain the total extract of Clematis clematis, and then concentrate under reduced pressure , to obtain the total extract of Clematis clematis;

[0041] (2) Extraction: add sherwood oil in Clematis clematis ...

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Abstract

The invention relates to a radix clematidis active component as well as a preparation method and an application thereof. The method comprises three steps, namely extracting radix clematidis, leaching the radix clematidis, and conducting silica gel column chromatography separation. The extraction process of the radix clematidis active component disclosed by the invention is simple, low in cost and easy to implement; the obtained active component is high in purity and significant in therapeutic effect on rheumatoid arthritis; and the active component has a quite important value.

Description

technical field [0001] The invention specifically relates to an effective component of Clematis clematis and its preparation method and application. Background technique [0002] Rheumatoid arthritis (RA), also known as rheumatoid, is a chronic, inflammatory synovitis-based systemic, systemic immune disease; statistics show that RA occurs all over the world, with an average incidence of The disease can occur in adolescents, adults and the elderly, and the incidence rate of females is usually 2 to 3 times that of males. If proper treatment is not given, it will usually lead to joint destruction and deformity, and affect the patient's health. Quality of life; modern medical research shows that the proliferation of cells in the synovial lining or the invasion of a large number of inflammatory cells, new microvessels, the formation of pannus and the destruction of cartilage tissue can all lead to the occurrence of rheumatoid arthritis to a certain extent. Among them, Pannus and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/716A61P29/00A61P19/02A61K125/00
CPCA61K36/716A61K2236/333A61K2236/39A61K2236/50A61K2236/55
Inventor 付强郑玉忠袁海梅陈江
Owner CHENGDU UNIV