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Method for preparing base bionic viscous polyacrylamide hydrogel system

A technology of viscous hydrogel and polyacrylamide, which is applied in the field of preparation of base biomimetic viscous polyacrylamide hydrogel system, can solve the problems of low viscosity of polyacrylamide hydrogel, and achieve the improvement of low viscosity, excellent sticky effect

Inactive Publication Date: 2016-10-26
CHANGCHUN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problem of low viscosity of polyacrylamide hydrogel, the purpose of the present invention is to introduce the base contained in the organism into the polyacrylamide hydrogel system, so that the base molecule can be used as a viscous expression group, so that it has excellent stickiness

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 The preparation method of an adenine biomimetic viscous polyacrylamide hydrogel is as follows:

[0020] The structural formula of the adenine viscous hydrogel is as follows:

[0021] ;

[0022] The steps and conditions of the preparation method of the adenine viscous hydrogel are as follows:

[0023] a. Modification of adenine

[0024] Dissolve 1.35g (0.01mol) adenine in 20mL dimethylformamide (DMF) to prepare an adenine solution with a molar concentration of 0.5mol / L; add 1.94mL (0.014mol) triethyl to the above solution amine, placed in an ice bath and stirred for 30 minutes, then added 0.9 mL (0.011 mol) of acryloyl chloride, under the protection of nitrogen, stirred and reacted at room temperature for 5 hours to obtain a modified adenine base monomer solution; The modified adenine base monomer is precipitated and precipitated with a polar solvent ether, and then suction-filtered with a Buchner funnel, and the filtered modified adenine base monomer is d...

Embodiment 2

[0029] Example 2 The preparation method of an adenine biomimetic viscous polyacrylamide hydrogel is as follows:

[0030] The structural formula of the adenine viscous hydrogel is the same as in Example 1;

[0031] a. Modification of adenine

[0032] Dissolve 1.35g (0.01mol) adenine in 20mL dimethylformamide (DMF) to prepare an adenine solution with a molar concentration of 0.5mol / L; add 2.10mL (0.015mol) triethyl to the above solution amine, placed in an ice bath and stirred for 30 minutes, then added 0.95 mL (0.012 mol) of acryloyl chloride, under the protection of nitrogen, stirred and reacted at room temperature for 6 hours to obtain a modified adenine base monomer solution; The modified adenine base monomer is precipitated and precipitated with a polar solvent ether, and then suction-filtered with a Buchner funnel, and the filtered modified adenine base monomer is dried to obtain an adenine base with a double bond base monomer; the molar ratio between the adenine, acrylo...

Embodiment 3

[0036] Example 3 The preparation method of an adenine biomimetic viscous polyacrylamide hydrogel is as follows:

[0037] The structural formula of the adenine viscous hydrogel is the same as in Example 1;

[0038] a. Modification of adenine

[0039]Dissolve 1.35g (0.01mol) adenine in 20mL dimethylformamide (DMF) to prepare an adenine solution with a molar concentration of 0.5mol / L; then add 2.20mL (0.016mol) triethyl to the above solution amine, placed in an ice bath and stirred for 30 minutes, then added 1.05 mL (0.013 mol) of acryloyl chloride, under the protection of nitrogen, stirred and reacted at room temperature for 7 hours to obtain a modified adenine base monomer solution; The modified adenine base monomer is precipitated and precipitated with a polar solvent ether, and then suction-filtered with a Buchner funnel, and the filtered modified adenine base monomer is dried to obtain an adenine base with a double bond base monomer; the molar ratio between the adenine, ac...

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Abstract

The invention relates to a method for preparing a base bionic viscous polyacrylamide hydrogel system, comprising preparation methods of adenine viscous hydrogel, guanine viscous hydrogel, thymine viscous hydrogel, cytosine viscous hydrogel and uracil viscous hydrogel; bases include adenine, guanine, thymine, cytosine and uracil. The bases comprised in living organisms are introduced to the polyacrylamide hydrogel system, and base molecules are used as viscous expression groups, so that the system is imparted good viscosity; the prepared polyacrylamide hydrogel system is viscous to metals, glasses, plastics, rubbers and ceramics; the hydrogel preparation method solves the defect that traditional polyacrylamide hydrogel is low in viscosity.

Description

technical field [0001] The invention belongs to the technical field of polymer hydrogel, and relates to a preparation method of a base bionic adhesive polyacrylamide hydrogel system. Background technique [0002] Because hydrogel contains a lot of water and has a perfect three-dimensional network structure, it is endowed with the characteristics of "soft matter". This structure is similar to biological tissue, and has important application prospects in the field of biomedical materials. Among them, viscous hydrogels have unique advantages in tissue engineering, medical dressings, and controlled release of drugs. However, for hydrogels, the development of their viscosity has been challenging due to their inherent water content. However, through the continuous efforts of researchers, a large number of viscous hydrogels have been reported. Adhesive hydrogels are of great interest in cell encapsulation, 3D printed organs, tissue adhesives, and bioglues. [0003] At present, v...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/00C08F220/56C08F220/60
CPCB01J13/0065C08F220/56C08F220/603C08F220/60
Inventor 高光辉刘鑫张颖
Owner CHANGCHUN UNIV OF TECH
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