Norcantharidin monomer-acid monoester derivative and anti-tumor application thereof

A technology of norcantharidin and monoacid monoester, which is applied in the direction of antineoplastic drugs, drug combinations, and active ingredients of heterocyclic compounds, and can solve the structure and synthesis method of norcantharidin monoacid monoester derivatives that have not been reported yet. , low bioavailability, poor water solubility, etc.
CN106083879AInactive Publication Date: 2016-11-09ZUNYI MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ZUNYI MEDICAL UNIVERSITY
Publication Date
2016-11-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a norcantharidin monomer-acid monoester derivative and an application thereof. The structural formula of the derivative is shown as the No.3 formula (please see the specification), wherein R is selected from alkyl or benzyl of C1 to C3. An activity test proves that the third designed and synthesized norcantharidin monomer-acid monoester derivative has good inhabitation activity in liver cancer tumor cells, stomach cancer tumor cells and colon cancer tumor cells, and can be expected to be applied to preparing medicine for resisting the three tumors.
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Description

technical field

[0001] The invention belongs to the field of new drug design and synthesis, and specifically relates to a novel norcantharidin monoacid monoester derivative and its antitumor application. Background technique

[0002] Mylabris, also written as Mylabris, commonly known as banmiao, Spanish fly, etc., has been recorded in the earliest existing Chinese pharmacy monographs "Compendium of Materia Medica" and "Shen Nong's Materia Medica". Cantharidin is the dry body of the insects of the family Mythaceae, the southern large spot or the yellow-black small spot, which belongs to the insect of the order Coleoptera. It is one of the earliest medicinal materials with anti-cancer effects discovered in my country. Cantharidin is pungent, hot, and has strong nephrotoxicity. It also has the effects of removing blood stasis, removing stasis, reducing swelling, and attacking toxins and erosions. It is often used clinically for the treatment of malignant sores, stubborn ringwor...

Claims

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