A porcine deltacoronavirus strain

A pig delta, coronavirus technology, applied in the direction of virus, virus/phage, positive-sense single-stranded RNA virus, etc., can solve the problems of non-interactive immunity, no common antigenicity, low mortality rate, etc.

Active Publication Date: 2020-02-07
HENAN AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

More importantly, the epidemiology and pathological autopsy of PDCoV are very similar to those of PED and TGE, but the mortality rate is slightly lower than the latter two. They have no common antigenicity and cannot be cross-immunized. PEDV, TGEV, PDCoV, etc. The disease caused by the mixed infection is a major problem in the global pig industry, causing great losses to the pig industry
At present, there is no effective treatment and vaccine for PDCoV, so the isolation and identification of the virus is of great significance to the prevention and treatment of this disease

Method used

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  • A porcine deltacoronavirus strain
  • A porcine deltacoronavirus strain
  • A porcine deltacoronavirus strain

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0013] 1. Materials and methods

[0014] 1.1 Source of disease material

[0015] On November 11, 2015, diarrhea occurred in a pig farm (200 sows) in Henan Province. The sows and piglets had yellow watery diarrhea 3 days after delivery. The piglets had rough coat, poor appetite and lethargy. , the root of the tail is stained with feces, and the anus is red and swollen if the diarrhea is severe. A total of 5 litters (58 heads) were produced in this field, and the mortality rate was 31% (15 / 58). The piglets were dissected, and it was found that the intestinal villi fell off, the intestinal wall became thinner, the lungs became substantively fleshy, and the kidneys had needle-like hemorrhages.

[0016] 1.2 Cells and strains

[0017] Porcine testicular cells (ST) and pig renal proximal tubular epithelial cells (LLC-PK) were purchased from the China Veterinary Inspection Institute and preserved by the Key Laboratory of Animal Food Safety in Henan Province.

[0018] 1.3 Main inst...

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Abstract

The invention discloses a porcine deltacoronavirus strain (Porcine Deltacoronavirus), CCTCC NO: V201558. The invention obtains a porcine delta coronavirus strain, which will lay an important foundation for the pathogenic research, epidemiological investigation, diagnosis and control and vaccine research of the virus.

Description

technical field [0001] The invention belongs to the field of microbial viruses and relates to new virus species, in particular to a porcine infectious delta coronavirus strain and its biological characteristics. Background technique [0002] Porcine Deltacoronavirus (PDCoV) is a novel coronavirus with clinical features mainly causing acute watery diarrhea in sows and piglets. Autopsy showed thinning of intestinal wall and shedding of intestinal villi. In 2012, PDCoV was first detected in pig feces in Hong Kong, and the virus has also been detected in mammals and birds. In February 2014, the virus was first detected in the United States, and its homology with the two strains in Hong Kong was 99%, and other strains of PDCoV were detected in pig farm feces in Canada and California in March of the same year. Subsequently, South Korea also isolated PDCoV strain KUN14-04 from the feces of piglets with diarrhea, and its homology and American strain homology are 99.6-99.8%. Later...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N7/00C12R1/93
CPCC12N7/00C12N2770/20021
Inventor 胡慧魏战勇杨国宇王亚宾曹贝贝韩丽兰培英张利卫
Owner HENAN AGRICULTURAL UNIVERSITY
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