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Serum miRNA marker related to esophageal squamous carcinoma assisted diagnosis and application of serum miRNA marker

A technology for esophageal squamous cell carcinoma and auxiliary diagnosis, which is applied in the fields of genetic engineering and oncology to achieve the effects of good stability, easy access, and minimally invasive access.

Active Publication Date: 2016-11-16
朱伟
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Problems solved by technology

However, there are still few large-sample miRNA lineage studies on esophageal squamous cell carcinoma.

Method used

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  • Serum miRNA marker related to esophageal squamous carcinoma assisted diagnosis and application of serum miRNA marker
  • Serum miRNA marker related to esophageal squamous carcinoma assisted diagnosis and application of serum miRNA marker
  • Serum miRNA marker related to esophageal squamous carcinoma assisted diagnosis and application of serum miRNA marker

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Embodiment Construction

[0036] The inventor collected a large number of venous serum samples from the First Affiliated Hospital of Nanjing Medical University and the First People's Hospital of Changzhou from 2013 to 2015, and selected The samples of 200 cases of esophageal squamous cell carcinoma and 188 cases of normal controls were used as the experimental samples for the initial screening of Exiqon miRNA qPCR panel chip and subsequent series of qRT-PCR verification. At the same time, 36 cases of esophageal squamous cell carcinoma tissues and 36 cases of paracancerous tissues were retained. The selected patients' serum samples were all from patients who had not undergone surgery, radiotherapy and chemotherapy intervention and were pathologically confirmed as esophageal squamous cell carcinoma. The demographic data and clinical data of these samples were collected systematically.

[0037] Refer to the flowchart ( figure 1 ), randomly selected 30 esophageal squamous cell carcinoma samples and 10 no...

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Abstract

The invention discloses a serum miRNA marker related to esophageal squamous carcinoma assisted diagnosis and application of the serum miRNA marker. The marker is one or more of miR-20b-5p, miR-28-3p, miR-192-5p, miR-223-3p and miR-296-5p. The serum miRNA marker serving as a novel biological marker is good in stability, minimally invasive, easy to obtain and high in sensitivity and specificity. The development and utilization of the molecular marker can provide a new direction for the diagnosis and further treatment of various diseases including tumor. The esophageal squamous carcinoma serum miRNA marker with clinical diagnosis potential can be obtained in a targeted manner by researches. The reliability and reproducibility of the group of miRNA serving as the non-invasive marker of the esophageal squamous carcinoma are proved by researches.

Description

technical field [0001] The invention belongs to the fields of genetic engineering and oncology, and relates to a serum miRNA marker related to the auxiliary diagnosis of esophageal squamous cell carcinoma and its application. Background technique [0002] Esophageal cancer is a common malignant tumor of the digestive tract. The mortality rate of esophageal cancer in China ranks fourth among cancers. In 2015, there were approximately 48,000 new cases of esophageal cancer and 38,000 deaths related to esophageal cancer. Cases of esophageal squamous cell carcinoma account for about 90% of the total number of esophageal cancers in my country. Although the current diagnostic methods, perioperative strategies, and radiotherapy and chemotherapy methods have been continuously improved, the risk of recurrence and metastasis of patients with esophageal squamous cell carcinoma after surgery is still relatively high, and the five-year survival rate is only 10%. 15%-25%. Since the early ...

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Application Information

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IPC IPC(8): C12Q1/68C12N15/113C12N15/11
CPCC12Q1/6886C12Q2600/158C12Q2600/178
Inventor 朱伟黄泽波单霞朱丹霞周鑫王同杉吴俚蓉刘平程文芳张澜张获
Owner 朱伟
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