Abamectin B2 chitosan microsphere, as well as preparation method and application thereof

A technology of chitosan microspheres and abamectin, applied in the direction of botany equipment and methods, applications, chemicals for biological control, etc., can solve the problems of complicated steps, achieve simple preparation methods, reduce oil phase Effects of medium and mild conditions

Active Publication Date: 2016-12-07
INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

High-speed centrifugation can handle larger sample volumes, but the subsequent steps are still relatively complicated

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: 11.5% Abamectin B 2 Preparation of chitosan microspheres

[0027] Weigh 1g Abamectin B 2 The original drug was dissolved in 2 mL of ethyl acetate, and 0.5 g of NP-18 was added and stirred to dissolve into a soluble solution of abamectin for later use. Dissolve 4g chitosan in 400mL 1% hydrochloric acid solution, stir and dissolve on a heated magnetic stirrer, cool to room temperature after dissolving, add avermectin B 2 Soluble agent, stirred into emulsion. Then enter the spray dryer, spray dry at the air inlet 140°C, the air outlet 70°C, and the peristaltic pump speed 300mL / h to obtain Abamectin B 2 Chitosan microsphere powder. Determination by high performance liquid chromatography, abamectin B 2 The drug loading of chitosan microspheres is 11.54%. After the detection of the laser particle size analyzer, the particle size of the microspheres D 50 is 10.06 μm and the span is 5.51.

[0028] Following the same steps as in Example 1, the following exampl...

Embodiment 2

[0029] Embodiment 2: 12.8% Abamectin B 2 Preparation of chitosan microspheres

[0030] Weigh 2g Abamectin B 2 The original drug was dissolved in 4mL of ethyl acetate, and 1g of OP-21 was added and stirred to dissolve into a soluble solution of abamectin for later use. Dissolve 4g chitosan in 400mL 0.5% formic acid solution, stir and dissolve on a heated magnetic stirrer, cool to room temperature after dissolving, add avermectin B 2 Soluble agent, stirred into emulsion. Then enter the spray dryer, spray dry at the air inlet 110°C, the air outlet 55°C, and the peristaltic pump speed 300mL / h to obtain Abamectin B 2 Chitosan microsphere powder. As determined by high-performance liquid chromatography, the drug-loading capacity of the avermectin B2 chitosan microspheres is 12.81%. After the detection of the laser particle size analyzer, the particle size of the microspheres D 50 is 11.59 μm and the span is 3.05.

Embodiment 3

[0031] Embodiment 3: 12% Abamectin B 2 Preparation of chitosan microspheres

[0032] Weigh 1g Abamectin B 2 The original drug was dissolved in 2mL of acetone, and 0.5g of Nongru 602# was added, stirred and dissolved to form a soluble solution of abamectin for later use. Dissolve 4g chitosan in 400mL 0.5% phosphoric acid solution, stir and dissolve on a heated magnetic stirrer, cool to room temperature after dissolving, add avermectin B 2 Soluble agent, stirred into emulsion. Spray drying at an air inlet of 130°C, an air outlet of 65°C, and a peristaltic pump speed of 500mL / h to obtain avermectin B 2 Chitosan microsphere powder. Determination by high performance liquid chromatography, abamectin B2 The drug loading of chitosan microspheres is 12.21%. After the detection of the laser particle size analyzer, the particle size of the microspheres D 50 It is 11.02 μm and the span is 3.06.

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Abstract

The invention relates to a method for preparing a novel preparation of pesticide, and particularly relates to an abamectin B2 chitosan microsphere, as well as a preparation method and application thereof. The preparation comprises abamectin B2 and chitosan, wherein the mass percentage content of abamectin B2 is 5.0-20.0 percent. The preparation method comprises the steps of dispersing an abamectin B2 soluble solution in a chitosan aqueous solution in diluted acid, performing spray-drying through a spray drier, and collecting dried powder to obtain a chitosan microsphere product. The abamectin B2 chitosan microsphere can be used for preventing and controlling crop nematode. According to the preparation method, an emulsification-spray drying method is adopted to prepare the abamectin B2 chitosan microsphere, high-molecular polymer carrier is dissolved in an aqueous phase, and the effective ingredient is dissolved in an oil phase, so that the oil-phase medium is greatly reduced, and usage of harmful organic solvent is reduced; and the preparation method is simple and convenient, has mild condition, does not need harmful organic solvent, has good environment compatibility, and is especially applicable to industrial production.

Description

technical field [0001] The invention relates to a method for preparing pesticides, in particular to abamectin B2 chitosan microspheres, a preparation method and application thereof. Background technique [0002] The effective utilization rate of conventional pesticide spraying is only 20% to 30%. Most of the active ingredients of pesticides are lost to the atmosphere, soil, water and other environments, which not only pollutes the environment, but also is a great waste. Therefore, developing new pesticide formulations that are safe, environmentally friendly, long-lasting, and reduce environmental pollution is one of the future development directions of pesticide formulations. [0003] Microspheres (Microspheres or Microbeads) are new formulations of pesticides with sustained release function developed in recent years. They are spherical preparations prepared with polymer materials such as starch, chitosan, polylactic acid, and gelatin. The drugs in the microspheres Disperse...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/90A01N25/10A01N25/12A01P5/00
CPCA01N25/10A01N25/12A01N43/90A01N2300/00
Inventor 陈福良尹明明顺布尔
Owner INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI
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