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Preparation method of injectable nanocomposite hydrogel system having pH response characteristics

A nano-composite, responsive technology, applied in liquid delivery, non-active components of polymer compounds, pharmaceutical formulations, etc., can solve the problems of no stimulus response, material metabolism problems, etc., and achieve great social and economic benefits.

Active Publication Date: 2016-12-07
辽宁德玛生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In the prior art, injectable graphene / PVA hydrogel drug carriers have been prepared by self-assembly of supramolecules, but the drug release in such injectable hydrogel carriers is mainly achieved by surface corrosion of the hydrogel , and has no specific stimulus response characteristics, and PVA is a non-degradable material. When the molecular weight exceeds a certain value, the metabolism of the material in the body will have certain problems.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Dissolve the pH-sensitive cyclodextrin derivative in dichloromethane to form a cyclodextrin / dichloromethane solution at a concentration of 10% (w / v), and ultrasonically pulverize it in a sealed ice bath for 2 minutes; then add a certain concentration and volume of double-bonded Gelatin / PBS (pH=7.5) solution, the concentration is 1% (w / v); the volume ratio of double-bonded gelatin / PBS (pH=7.5) solution to cyclodextrin / dichloromethane solution is 6:1; sealed ultrasonic The cells were pulverized for 3 minutes to form a primary emulsion, and then a certain concentration and volume of double-bonded gelatin / PBS (pH=7.5) solution was added to obtain a mixed emulsion with a concentration of 0.3% (w / v); the volume ratio of the primary emulsion to the mixed emulsion was 1: 2. Stir for 10 h with a magnetic stirrer at 1300 r / min to allow the organic solvent to fully evaporate to form an emulsion of cyclodextrin nanoparticles with pH-sensitive properties. A certain amount of double-...

Embodiment 2

[0032] Dissolve the pH-sensitive cyclodextrin derivative in dichloromethane to form a cyclodextrin / dichloromethane solution at a concentration of 15% (w / v), and ultrasonically pulverize it in a sealed ice bath for 2 minutes; then add a certain concentration and volume of double-bonded Gelatin / PBS (pH=7.5) solution, the concentration is 1% (w / v); the ratio of water to oil is 6:1; sealed ultrasonic cell pulverization for 3 minutes to form primary emulsion, then add a certain concentration and volume of double-bonded gelatin / PBS (pH=7.5) solution to obtain a mixed emulsion with a concentration of 0.3% (w / v); the ratio of primary emulsion to mixed emulsion is 1:2, stirred for 10h under a magnetic stirrer at 1300r / min, and the organic solvent is fully evaporated to form a pH-sensitive Properties of cyclodextrin nanoparticles in emulsions. A certain amount of double-bonded gelatin was added so that the final gelatin concentration was 20%. Add 0.05% (w / v) I2959 to the above emulsion...

Embodiment 3

[0036] Dissolve the pH-sensitive cyclodextrin derivative in dichloromethane to form a cyclodextrin / dichloromethane solution at a concentration of 5% (w / v), and ultrasonically pulverize it in a sealed ice bath for 2 minutes; then add a certain concentration and volume of double bonded Gelatin / PBS (pH=7.5) solution, the concentration is 1% (w / v); the ratio of water to oil is 6:1; sealed ultrasonic cell pulverization for 3 minutes to form primary emulsion, then add a certain concentration and volume of double-bonded gelatin / PBS (pH=7.5) solution to obtain a mixed emulsion with a concentration of 0.3% (w / v); the ratio of primary emulsion to mixed emulsion is 1:2, stirred for 10h under a magnetic stirrer at 1300r / min, and the organic solvent is fully evaporated to form a pH-sensitive Properties of cyclodextrin nanoparticles in emulsions. A certain amount of double-bonded gelatin was added so that the final gelatin concentration was 15%. Add 0.05% (w / v) I2959 to the above emulsion,...

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PUM

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Abstract

The invention discloses a preparation method of injectable nanocomposite hydrogel having pH response characteristics. The preparation method includes the following steps that 1, material preparation is performed, and cyclodextrin and double-bonded gelatin having the pH response characteristics are prepared according to the prior art; 2, a hydrogel precursor solution containing cyclodextrin nanoparticles is prepared, a pH sensitive cyclodextrin derivative is dissolved in dichloromethane to form a cyclodextrin / dichloromethane solution, ultrasonic grinding is performed in a sealed ice bath, a certain concentration and volume of double-bonded gelatin / PBS solution having the pH of 7.5 is added to obtain mixed emulsion, magnetic stirring is performed, and the double-bonded gelatin is added after an organic solvent is evaporated fully; 3, a certain amount of light initiator is added to the solution, and the nanocomposite hydrogel is prepared after lighting is performed by using an ultraviolet lamp in a reactor for a certain time. The prepared injectable nanocomposite hydrogel having the pH response characteristics has wide application in the field of biological medicines.

Description

technical field [0001] The invention belongs to the technical field of new materials, and in particular relates to the preparation of a multifunctional injectable composite hydrogel. Background technique [0002] In the field of biomedicine, using carrier materials to control the release rate, time and place of drugs in the human body is an effective way to improve the efficacy of drugs, reduce and reduce the toxic and side effects of drugs and reduce the number of administrations. An ideal drug carrier should have good biocompatibility, biodegradability, physical, chemical and biological stability, extremely low toxicity, and high drug loading. The use of carrier materials to achieve cell delivery and transfection is also one of the research hotspots in this field, which plays a vital role in human health. Many materials are currently used as carriers, including hydrogels, microspheres, membranes, and functionalized particles. Among them, injectable biomaterials are impla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/42A61K47/40
CPCA61K9/0019A61K9/06A61K47/40A61K47/42
Inventor 王昕陈频胡小红
Owner 辽宁德玛生物科技有限公司
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