Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Mirabegron composition

A technology for mirabegron and composition, which is applied in the field of mirabegron composition and its preparation, can solve problems such as drug poisoning, and achieve the effects of slow release and excellent dissolution behavior

Inactive Publication Date: 2016-12-07
DISHA PHARMA GRP +1
View PDF6 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The emergence of burst release phenomenon will easily lead to the absorption of a large dose at a certain time by the user, which will lead to the occurrence of drug poisoning

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Mirabegron composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1. Mirabegron 25g, hypromellose (K4M) 15g, dibutylhydroxytoluene 0.15g, polyoxyethylene (POLYOX N80) 160g, polyethylene glycol 6000 10g, stearic acid Magnesium 1.4g, powdered silicon dioxide 8g. Prepare 1000 tablets according to the preparation method described in the technical scheme section.

Embodiment 2

[0023] Example 2, Mirabegron 50g, hypromellose (K4M) 45g, dibutylhydroxytoluene 0.3g, polyoxyethylene (POLYOX N80) 50g, polyethylene glycol 6000 32g, stearic acid Magnesium 0.8g, powdered silicon dioxide 15g. Prepare 1000 tablets according to the preparation method described in the technical scheme section.

Embodiment 3

[0024] Example 3, Mirabegron 30g, hypromellose (K4M) 40g, dibutylhydroxytoluene 0.15g, polyoxyethylene (POLYOX N80) 120g, polyethylene glycol 6000 15g, stearic acid Magnesium 0.8g, powdered silicon dioxide 13g. Prepare 1000 tablets according to the preparation method described in the technical scheme section.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a mirabegron composition and a preparation method thereof and belongs to the technical field of pharmacy. According to the technical scheme, the mirabegron sustained-release composition is characterized in that every 1000 tablets comprise 25-50 g of mirabegron, 15-45 g of hydroxypropyl methylcellulose (K4M), 0.15-0.3 g of butylated hydroxytoluene, 50-160 g of polyoxyethylene (POLYOX N80), 10-32 g of polyethylene glycol 6000, 0.8-1.4 g of magnesium stearate and 8-15 g of powdery silicon dioxide. Through implementation of the technical scheme, a clinic medicine which is excellent in dissolution behavior is obtained. Due to the adding of silicon dioxide, the sustained release of active matter mirabegron is performed to some extent.

Description

technical field [0001] The invention relates to a mirabegron composition and a preparation method thereof, belonging to the technical field of pharmacy. Background technique [0002] Overactive bladder (OAB) is a syndrome characterized by urinary urgency symptoms, often accompanied by frequent urination and nocturia, with or without urge incontinence, which obviously affects the daily life and social activities of patients, and has been Become a major disease that plagues people. In recent years, as my country has entered an aging society, and the growth of diabetes and nervous system damage diseases, the incidence of related diseases secondary to this - overactive bladder has also increased year by year. [0003] It has been reported that the overall prevalence of overactive bladder (OAB) is 6% for people over the age of 18, and can reach 11.3% for people over the age of 50, which has seriously affected people's quality of life. According to the guidelines for the diagnos...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/426A61K47/04A61P13/10
CPCA61K9/2009A61K9/0002A61K31/426
Inventor 白莉杨豪伟侯铁强
Owner DISHA PHARMA GRP
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com